Association between food insecurity and kidney stones in the United States: Analysis of the National Health and Nutrition Examination Survey 2007–2014

Wang, Wei; Liu, Xi; Shi, Yixiao; Wei, Xin

doi:10.3389/fpubh.2022.1015425

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…This was ascertained by the participant’s response to the question, “Have you/Has sample person (SP) ever had a kidney stone?” Those who answered ‘yes’ were categorized as having nephrolithiasis. The validity of self-reported data on the occurrence of kidney stones has been confirmed by previous studies ( 4 , 23 , 24 ).…”

Section: Methodssupporting

confidence: 73%

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Associations between the platelet/high-density lipoprotein cholesterol ratio and likelihood of nephrolithiasis: a cross-sectional analysis in United States adults

Ni,

Lv,

et al. 2024

Front. Endocrinol.

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AimsThe primary objective of this study was to investigate the relationship between the platelet/high-density lipoprotein cholesterol ratio (PHR) and the prevalence of nephrolithiasis within the adult population of the United States.MethodsThe data used in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. The analysis included a non-pregnant population aged 20 years or older, providing proper PHR index and nephrolithiasis data. The research utilized subgroup analyses and weighted univariate and multivariable logistic regression to evaluate the independent association between the PHR and the susceptibility to nephrolithiasis.ResultsThe study comprised 30,899 participants with an average PHR value of 19.30 ± 0.11. The overall prevalence rate of nephrolithiasis was estimated at 9.98% with an increase in the higher PHR tertiles (T1, 8.49%; T2, 10.11%; T3, 11.38%, P < 0.0001). An elevated PHR level was closely linked with a higher susceptibility to nephrolithiasis. Compared with patients in T1, and after adjusting for potential confounders in model 2, the corresponding odds ratio for nephrolithiasis in T3 was 1.48 (95% CI: 1.06 to 2.08), with a P-value = 0.02. The results of the interaction tests revealed a significant impact of chronic kidney disease on the relationship between PHR and nephrolithiasis. Furthermore, the restricted cubic spline analyses exhibited a positive, non-linear correlation between PHR and the risk of nephrolithiasis.ConclusionA convenient biomarker, the PHR, was independently associated with nephrolithiasis and could be a novel biomarker in predicting occurrence in clinical decision.

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Section: Methodssupporting

confidence: 73%

“…Those who answered 'yes' were categorized as having nephrolithiasis. The validity of selfreported data on the occurrence of kidney stones has been confirmed by previous studies (4,23,24).…”

Section: Exposure Variables and Outcomessupporting

confidence: 65%

Associations between the platelet/high-density lipoprotein cholesterol ratio and likelihood of nephrolithiasis: a cross-sectional analysis in United States adults

Ni,

Lv,

et al. 2024

Front. Endocrinol.

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“…A previous study showed that there existed a significant association between food insecurity and kidney stones. 35 In addition, it was now generally accepted that kidney stone was also associated with metabolic abnormalities in the body, such as hyperparathyroidism and hypercortisolism. 36 Both thyroid function and cortisol function were regulated by the brain and nerves, and studies have shown that nutritional deficiencies have a direct and severe impact on brain and nerve development.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood

Yan¹,

Huang²,

Feng³

2023

IJGM

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Background The Great Chinese Famine, as the famine of 1959–1961 was often known. Famine exposure during early life was proven to be associated with some kidney diseases but has not been studied with kidney stone. We aimed to investigate the relationship between exposure to the Great Chinese Famine in early life and the incidence of kidney stone in adulthood. Methods From 1 January 2017 to 31 December 2018, a total of 19,658 eligible adults were recruited in a cross-sectional survey who were born between 1 October 1952 and 30 September 1964 in Guangdong, China. Participants were separated into kidney stone and none-kidney stone groups based on kidney stone status. According to birth data, participants were divided into non-exposed, fetal-exposed, early-, mid-, and late-childhood-exposed groups. Multivariate logistic regression, subgroup analysis and interaction test were used to estimate the odds ratios (ORs) and confidence intervals (CIs) between famine exposure and kidney stone. Results In total, 19,658 (12,246 female, mean age 59.31 ± 3.68 years) subjects were enrolled, and 3219 (16.38%) participants with kidney stone. The prevalence of kidney in none-, fetal-, early-, mid-, and late-childhood-exposed groups were 645 (14.9%), 437 (15.9%), 676 (16.3%), 743 (17.0%), and 718 (17.6%), respectively (P<0.001). When compared with the unexposed group, the fully adjusted ORs for kidney stone from fetal-exposed, early-, mid- to late-childhood-exposed groups were 1.37 (95% CI: 1.13, 1.68, P=0.002), 1.98 (95% CI: 1.45, 2.72, P<0.001), 2.94 (95% CI: 1.96, 4.42, P<0.001), and 3.48 (95% CI: 2.11, 5.72, P<0.001), respectively (P for trend<0.001). Subgroup analyses revealed no interactions between the famine effect on kidney stones and body mass index, gender, smoking status, history of diabetes or hypertension (all P for interaction >0.05). Conclusion This study found that exposure to the Great Chinese Famine during early life was independently associated with the increased incidence of kidney stone in adulthood.

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“…The NHANES is a population-based cross-sectional survey designed to assess health and nutritional status within the US population ( 14 ). Since 1999, approximately 5,000 nationally representative individuals have been surveyed annually, and related data have been published biennially.…”

Section: Methodsmentioning

confidence: 99%

“…The NHANES is a population-based cross-sectional survey designed to assess health and nutritional status within the US population (14). Since 1999, approximately 5,000 nationally In terms of smoking status, 34,657 participants out of 59,842 participants were screened in our study population.…”

Section: The Study Population In Nhanesmentioning

confidence: 99%

Associations between smoke exposure and kidney stones: results from the NHANES (2007–2018) and Mendelian randomization analysis

Huang,

Wang,

et al. 2023

Front. Med.

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PurposeIt is currently controversial whether smoke exposure is associated with the risk of kidney stones. Herein, publicly available databases were combined to explore relationships with the risk of nephrolithiasis in terms of smoking status and serum cotinine concentrations.Materials and methodsFirst, we conducted an observational study using data from 2007 to 2018, based on the National Health and Nutrition Examination Survey (NHANES) database. Univariate analysis, multivariate logistic regression, trend testing, restricted cubic spline (RCS), and multiple imputation (MI) were the main analytical methods of our study. Then, A Mendelian randomization (MR) analysis was performed to explore the causal relationship between serum cotinine and nephrolithiasis. Genetic instruments for serum cotinine and pooled data for kidney stones were derived from publicly available large-scale genome-wide association studies (GWAS). Inverse-variance weighting (IVW) was the primary method for our MR analysis.ResultsA total of 34,657 and 31,352 participants were included in the observational study based on smoking status and serum cotinine concentrations, respectively. Under full adjustment of covariates, current smokers had an increased risk of kidney stones compared to non-smokers [OR = 1.17 (1.04–1.31), P = 0.009, P for trend = 0.010]. Compared with serum cotinine of <0.05 ng/ml, serum cotinine levels of 0.05–2.99 ng/ml [OR = 1.15 (1.03–1.29), P = 0.013] and ≥3.00 ng/ml [OR = 1.22 (1.10–1.37), P < 0.001] were observed to have a higher risk of nephrolithiasis (P for trend < 0.001). In addition, a non-linear relationship between log2-transformed serum cotinine and the risk of nephrolithiasis was found (P for non-linearity = 0.028). Similar results were found when serum cotinine (log2 transformation) was used as a continuous variable [OR = 1.02 (1.01–1.03), P < 0.001] or complete data was used to analyze after MI. In the MR analysis, genetically predicted high serum cotinine was causally related to the high risk of nephrolithiasis [IVW: OR = 1.09 (1.00–1.19), P = 0.044].ConclusionCurrent smoking and high serum cotinine concentrations may be associated with an increased risk of kidney stones. Further research is needed to validate this relationship and explore its underlying mechanisms.

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Association between food insecurity and kidney stones in the United States: Analysis of the National Health and Nutrition Examination Survey 2007–2014

Cited by 6 publications

References 34 publications

Associations between the platelet/high-density lipoprotein cholesterol ratio and likelihood of nephrolithiasis: a cross-sectional analysis in United States adults

Associations between the platelet/high-density lipoprotein cholesterol ratio and likelihood of nephrolithiasis: a cross-sectional analysis in United States adults

Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood

Associations between smoke exposure and kidney stones: results from the NHANES (2007–2018) and Mendelian randomization analysis

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