Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Chang, Chun Chin; Hsu, Chien Yi; Huang, Po Hsun; Liu, Li Kuo; Chen, Liang Kung; Chen, Jaw Wen J.W.; Lin, Shing Jong

doi:10.1111/ggi.13099

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…Therefore, inflammatory changes in the body play a role in developing frailty. Levels of hs-CRP have been found to be an independent factor affecting frailty 28…”

Section: Discussionmentioning

confidence: 99%

<p>Association between frailty and the cardio-ankle vascular index</p>

Qin¹,

Mingzhao²,

Jia³

et al. 2019

CIA

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Purpose Frailty and atherosclerotic diseases are prevalent among the older people and usually present the same pathogenesis and risk factors. Therefore, the aim of this study was to determine the association between frailty and atherosclerosis. Patients and methods The enrolled participants were 171 patients aged 60–96 years in Beijing Tongren Hospital. Data that were collected included sex, age, height, weight, calculated body mass index (BMI), past medical history, comorbidities (including hypertension, coronary heart disease [CHD], and diabetes), ability to perform activities of daily living (ADL) as measured using the Barthel index, handgrip strength, 15-feet (4.57 m) walking speed, body composition features determined by bioelectrical impedance analysis, the ankle–brachial index (ABI), and atherosclerosis determined by the cardio-ankle vascular index (CAVI). Patients were divided into frail, pre-frail, and non-frail groups using Fried’s frailty index. ANOVA was used to assess the differences among these groups. Linear correlation analysis was used to examine the relationship between the CAVI and frailty phenotype. Ordinal multivariate logistic regression analysis was used to examine the factors affecting frailty and the relationship between frailty and atherosclerosis. Results The population was categorized as 21.3% frail, 38.4% pre-frail, and 40.3% non-frail. Patients in the frail group were older, had lower handgrip strength, slower walking speed, and a lower ABI and a higher proportion of carotid intima-media thickening with values of at least 1 mm compared with those in the pre-frail and non-frail groups. The CAVI score was higher in the frail group than that in the other two groups. There were significant inverse linear correlations between grip strength, walking speed, and the CAVI. CAVI showed an independent risk factor for frailty (OR: 2.013, 95% CI 1.498–2.703, p <0.001). Conclusion Our study shows that arterial stiffness is associated with frailty in older patients, even when adjusting for multiple factors.

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“…Therefore, inflammatory changes in the body play a role in developing frailty. Levels of hs-CRP have been found to be an independent factor affecting frailty 28…”

Section: Discussionmentioning

confidence: 99%

<p>Association between frailty and the cardio-ankle vascular index</p>

Qin¹,

Mingzhao²,

Jia³

et al. 2019

CIA

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“…Frailty was associated with a change in the inflammatory state. Increased inflammatory factors are important factors with respect to the incidence of frailty [ 25 , 26 ]. The NLR is a significant indicator of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Inflammation markers are associated with frailty in elderly patients with coronary heart disease

Hou

Xue

Mao

et al. 2018

Aging

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The neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) are important indicators of adverse outcomes and have predictive value for many diseases; however, the relationships between frailty, and the NLR and RDW in patients with coronary heart disease (CHD) have not been determined. In this cross-sectional study, we investigated the association between frailty, and the NLR and RDW in elderly CHD patients ≥ 60 years of age. Frailty was defined according to frailty phenotype. Of 345 patients enrolled in the study, 22.6%, 58.3%, and 19.1% were characterized as robust, pre-frail, and frail, respectively. A significant positive correlation was observed between frailty and the NLR (r = 0.169) and RDW (r = 0.196). After adjusting for confounders, linear regression analyses showed that participants in the 4th quartile of the NLR or RDW were more likely to have a higher frailty phenotype score. Based on multivariable logistic regression, patients in the 4th quartile of the NLR and RDW, the fully-adjusted odds ratios for incident frailty were 2.894 (p = 0.011) and 2.494 (p = 0.040), respectively. Our findings indicate that frailty is associated with the NLR and RDW in elderly patients with CHD.

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“…The carotid intima–media thickness (cIMT) was measured at a site with no discrete plaque along a 10-mm-long segment of the far wall of the CCA. The average of the bilateral cIMTs was calculated for analysis 22 .…”

Section: Methodsmentioning

confidence: 99%

Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study

Chang¹,

Wu²,

Liu³

et al. 2018

Sci Rep

Self Cite

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Serum uric acid level is a risk factor for cardiovascular disease (CVD). However, whether it is an independent risk factor or not remains controversial. We analyzed the association between serum uric acid level and cardiovascular risk. In total, 973 nonhypertensive and nondiabetic participants in the I-Lan Longitudinal Aging Study were eligible for this study. Subjects were divided into tertiles according to uric acid levels. The 10-year cardiovascular risk was calculated using Framingham risk score (FRS). Study subjects in the highest tertile of serum uric acid level were older, more likely to be male, and had higher systolic blood pressure, body mass index, carotid artery intima–media thickness and serum triglyceride, high-sensitivity C-reactive protein, and low-density lipoprotein cholesterol levels and lower serum high-density lipoprotein cholesterol levels (all p < 0.05). Subjects in the highest tertile had significantly higher FRS (p < 0.001). After adjusting for other risk factors, serum uric acid level remained associated significantly with the FRS (p < 0.05). In binary logistic regression analysis, the serum uric acid level was an independent predictive factor for high (≥20%) FRS (odds ratio 1.33, 95% confidence interval 1.10–1.68). These findings warrant attention to this cardiovascular risk factor in apparently healthy adults.

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Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population

Cited by 17 publications

References 22 publications

<p>Association between frailty and the cardio-ankle vascular index</p>

<p>Association between frailty and the cardio-ankle vascular index</p>

Inflammation markers are associated with frailty in elderly patients with coronary heart disease

Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study

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