Association between functional gastrointestinal disorders and migraine in children and adolescents: a case-control study

Gal, Julie Le; Molina, Jean‐Michel; Rinaldi, Victoria Elisa; Spiri, Daniele; Moretti, Raffaella; Bettati, Donatella; Romanello, Silvia; Berlese, Paola; Lualdi, Rosa; Boizeau, Priscilla; Viala, Jérôme; Bellaïche, M.; Zuccotti, Gian Vincenzo; Crichiutti, Giovanni; Alberti, Corinne; Titomanlio, Luigi

doi:10.1016/s2468-1253(16)30038-3

Cited by 37 publications

(32 citation statements)

References 34 publications

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“…Recent studies also suggest that migraine may be associated with other gastrointestinal disorders, including irritable bowel syndrome, inflammatory bowel syndrome and functional gastrointestinal disorders (FGIDs). Le Gal et al [ 46 ] did a robust case-control study in the emergency departments of four European hospitals to establish the prevalence of FGIDs in children and adolescents with primary headaches and investigate a possible relationship with migraine. They compared the prevalence of ten FIGDs in three groups of patients aged 6–18 years (257 with migraine, 167 with tension-type headache, and a control group of 648 headache-free individuals).…”

Section: Reviewmentioning

confidence: 99%

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

et al. 2017

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This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated. New diagnostic tools are available for ascertaining brucellosis, celiac disease and viral infections. The usefulness of aCGH as first-tier test is confirmed in patients with neurodevelopmental disorders. Novel information have been provided on the safety of milk for infants. Recent advances in the treatment of common disorders, including neonatal respiratory distress syndrome, hypo-glycemia in newborns, atopic dermatitis, constipation, cyclic vomiting syndrome, nephrotic syndrome, diabetes mellitus, regurgitation, short stature, secretions in children with cerebral palsy have been reported. Antipyretics treatment has been updated by national guidelines and studies have excluded side effects (e.g. asthma risk during acetaminophen therapy). Vaccinations are a painful event and several options are reported to prevent this pain. Adverse effects due to metabolic abnormalities are reported for second generation antipsychotic drugs.

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Section: Reviewmentioning

confidence: 99%

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

et al. 2017

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“…In our study, 12.1% of children had significantly more often headaches than controls (2.6%). In another carefully designed case‐control study of 424 children and adolescents with headache and 648 controls (mean age, 11.0 years), functional gastrointestinal disorders were more common in the migraine (32%), tension‐type (25%) than in the control group (18%) . Specifically, functional dyspepsia, irritable bowel, and abdominal migraine were more common.…”

Section: Discussionmentioning

confidence: 99%

Incontinence and headache in preschool children

Gontard

Overs

Moritz³

et al. 2019

Neurourology and Urodynamics

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Aims Headaches in preschool children are associated with behavioral and gastrointestinal symptoms. As the co‐occurrence with incontinence is not known in young children, the aim of the study was to examine associations of headache, psychological symptoms and nocturnal enuresis (NE), daytime urinary incontinence (DUI), and fecal incontinence (FI) in a population‐based sample of preschool children. Methods All preschool children of a defined geographical area were examined at school‐entry. Parents completed a 22‐item questionnaire, including 14 headache, 4 incontinence, and 25 items of the Strength and Difficulties Questionnaire (SDQ). Five hundred eighty‐five children (50.4% males) with a mean age of 5.8 years were included. Results In total, 27.2% of all children had headaches. 15.7% had secondary and 11.3% primary headaches. Five children had migraine and five tension‐type headaches, while all others were unclassifiable. 9.4% of children had incontinence (7.7% NE; 2.4% DUI, 1.2% FI) and 4.0% constipation. The rates of incontinence did not differ between children with primary and those without headache for NE (12.9% vs 7.5%), DUI (3.1% vs 2.7%) or FI (3.0% vs 1.0%), but for constipation (12.1% vs 2.6%). Incontinent children had significantly more behavioral and externalizing symptoms, children with headache more internalizing problems. Primary headache was a significant predictor for internalizing, while constipation and FI were predictors for externalizing symptoms. Conclusions This population‐based study showed that headache is associated with constipation, but not with incontinence in preschool children. Headache and incontinence are common risk factors for specific psychological symptoms and should be assessed in clinical practice.

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“…There is evidence for association between FC and different diseases such as headache, migraine, overactive bladder, cow's milk allergy, rigid compulsive behavior, attention-deficit/hyperactivity disorder, nocturnal enuresis, and gastroesophageal reflux (15)(16)(17)(18)(19)(20). However, a few investigations evaluating the relationship between pediatric chest pain and FC were found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Constipation in Children with Idiopathic Chest Pain and Constipation Could Resolve Their Chest Pain

et al. 2019

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Background: Chest pain is one of the most frequent causes of a child's referral to a cardiologist. Objectives: The present study aimed at determining whether treatment of constipation in 4-17-year-old children with idiopathic chest pain stops their chest pain. Methods: The current descriptive study was conducted on all patients aged 4-17 years old with idiopathic chest pain referring to the Pediatric Cardiology Clinic of Hejazi Hospital, Shiraz, Iran in 2016. A diagnosis of idiopathic chest pain is established after a thorough history taking, physical examination, and appropriate laboratory investigations in patients with no abnormality in the heart, lung, musculoskeletal system, psychological condition, and upper gastrointestinal tract. The study patients were divided into two groups: 36 patients with constipation as cases and 27 patients without constipation as controls. Patients with constipation were supported with toilet training programs and pharmacological treatment. Relief of chest pain was evaluated in the two groups after four months. Results: There were no significant differences in terms of age, gender, weight, and height between the patients with idiopathic chest pain with and without constipation. The number and length of chest pain were significantly different between the case and control groups (P < 0.001 and 0.047, respectively). After medical treatment of constipation, chest pain was significantly stopped in patients with constipation compared with the ones without constipation (P < 0.001). Conclusions: The current study showed that resolution of constipation stopped chest pain in the patients with idiopathic chest pain and constipation. Physicians should consider treatment of constipation as a first modality in each patient with idiopathic chest pain and constipation due to its easy assessment.

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Association between functional gastrointestinal disorders and migraine in children and adolescents: a case-control study

Cited by 37 publications

References 34 publications

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

Incontinence and headache in preschool children

Treatment of Constipation in Children with Idiopathic Chest Pain and Constipation Could Resolve Their Chest Pain

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