Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2

Engelke, Christina E.H; Meinl, Walter; Boeing, Heiner; Glatt, Hansruedi

doi:10.1097/00008571-200003000-00008

Cited by 62 publications

(41 citation statements)

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“…In addition, the observed genotype frequencies for SULT1A1 are in line with previous studies from Germany. 18,43 In summary, we observed an increased risk for colorectal cancer associated with long-term cigarette smoking and frequent consumption of red and processed meat. Our findings suggest a modifying effect of SULT1A1 genotype on the association between environmental exposures and colorectal cancer risk, which was more pronounced for red meat consumption than for tobacco smoking.…”

Section: Discussionmentioning

confidence: 67%

SULT1A1 genotype and susceptibility to colorectal cancer

Lilla

Risch

Verla-Tebit

et al. 2006

Intl Journal of Cancer

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Several procarcinogens that are present in cooked red meat and tobacco smoke are substrates for sulfotransferase 1A1 (SULT1A1). The association between environmental exposures and colorectal cancer risk may be modified by individual differences in the metabolism. Thus, we investigated the effect of a common polymorphism in the SULT1A1 gene associated with decreased enzyme activity on the susceptibility to colorectal cancer in a populationbased case-control study. Patients (505) and 604 age-and sexmatched controls provided detailed risk factor information and were genotyped for SULT1A1 G638A using a fluorescence-based melting curve analysis method. Multivariate logistic regression analysis was used to estimate colorectal cancer risk associated with environmental exposures by SULT1A1 genotype. SULT1A1 genotype was not an independent risk factor for colorectal cancer. Risk of colorectal cancer associated with frequent consumption of red meat was significantly elevated among carriers of the SULT1A1*2 allele but not increased among subjects with the SULT1A1*1/*1 genotype (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.1 and OR 1.0, 95% CI 0.5-2.1, respectively). Colorectal cancer risk associated with 301 pack-years of active smoking was higher among carriers of the SULT1A1*2 allele (OR 1.7, 95% CI 1.0-3.2) than among individuals with the SULT1A1*1/*1 genotype (OR 1.1, 95% CI 0.6-2.1). Our results do not support a main effect of SULT1A1 genotype with regard to colorectal cancer but suggest that individuals with the low activity SULT1A1*2 allele may be at higher risk following carcinogen exposure than those with the SULT1A1*1/*1 genotype. ' 2006 Wiley-Liss, Inc.Key words: SULT1A1; genetic polymorphism; colorectal cancer; tobacco; meat Sporadic colorectal cancer is considered a multifactorial disease with both environmental and genetic factors contributing to individual risk. Environmental exposures that have been associated with an increased risk of colorectal cancer include consumption of red meat and long-term cigarette smoking.1,2 Both consumption of red meat cooked at high temperatures and tobacco smoking increase exposure to several potentially carcinogenic substances such as heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds. 3,4 Sulfotransferase 1A1 (SULT1A1) is involved in the Phase IImetabolism of xenobiotics and is expressed in the liver as well as in many extrahepatic tissues including colonic mucosa.5,6 The SULT1A1-catalyzed transfer of a sulfo moiety to its substrates usually increases their water solubility and thus facilitates excretion. However, the reaction with SULT1A1 may also lead to bioactivation of certain substances.7 A common polymorphism in the human SULT1A1 gene (G638A), referred to as SULT1A1*2 allele, leads to an amino acid change (Arg 213 His) and has been associated with decreased activity of the respective allozyme. 8,9 Hence, genetically determined differences in detoxification and bioactivation of xenobiotics may alter individual exposu...

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Section: Discussionmentioning

confidence: 67%

SULT1A1 genotype and susceptibility to colorectal cancer

Lilla

Risch

Verla-Tebit

et al. 2006

Intl Journal of Cancer

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“…4 The gene SULT1A2 is usually in linkage disequilibrium with SULT1A1, and high-activity alloenzymes (SULT1A1*Arg and SULT1A2* Asn) are associated together. 5 SULT1A1*His has been associated to a protective effect in colorectal cancer, 6 although other studies have not confirmed this finding. [7][8][9][10] We have tested the main hypothesis that polymorphisms in SULT1A1 and SULT1A2 modify the risk of colorectal cancer.…”

Section: Dear Sirmentioning

confidence: 97%

Polymorphisms in sulfotransferasesSULT1A1 andSULT1A2 are not related to colorectal cancer

et al. 2004

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Dear Sir,Cytosolic sulfotransferases (SULT) play an important role in Phase II metabolism of several xenobiotics. Although sulfonation in general exerts detoxifying effects, it may also lead to the bioactivation of certain promutagens and procarcinogens including heterocyclic amines that can be formed when meats are cooked at high temperature. 1,2 Several sulfotransferases have been identified in humans, which show important tissue distribution variability and different affinities for some substrates. For SULT1A1 and SULT1A2, 2 polymorphisms have been detected that lead to altered enzyme functions. SULT1A1 is highly expressed in numerous tissues including colon mucosa. Its variant SULT1A1*His was associated with decreased enzyme activity and thermostability in platelets and reduced activation of some pro mutagens in vitro 3 compared to SULT1A1*Arg. There are no published studies demonstrating the presence of SULT1A2 protein in any tissue. Using a modified protocol for electrophoresis, our group could separate SULT1A2 from other cross-immunoreactive SULT forms, including SULT1A1, and unambiguously detect the presence of moderate levels of SULT1A2 protein in some (but not all) colon mucosa samples investigated as well as in the colon carcinoma cell line Caco-2 (W. Meinl, W. Teubner, A. Lampen and H. R. Glatt, unpublished data). In vitro studies have shown that SULT1A2 can activate procarcinogens. 4 The gene SULT1A2 is usually in linkage disequilibrium with SULT1A1, and high-activity alloenzymes (SULT1A1*Arg and SULT1A2* Asn) are associated together. 5 SULT1A1*His has been associated to a protective effect in colorectal cancer, 6 although other studies have not confirmed this finding. [7][8][9][10] We have tested the main hypothesis that polymorphisms in SULT1A1 and SULT1A2 modify the risk of colorectal cancer. We have also explored whether these polymorphisms interact with exposures such as diet, alcohol, tobacco or drugs and with genetic alterations in the tumors.A hospital-based case-control study was conducted to assess risk factors of colorectal cancer and gene-environment interactions. Details about the study population, interviews and collection of biological samples have been published elsewhere. 11 Briefly, cases were patients with a new diagnosis of colorectal adenocarcinoma attending a University Hospital in Barcelona, Spain, between January 1996 and December 1998. Controls were selected from admissions to the same hospital during this period. To avoid selection bias of controls, the reason for admission had to be a disease not previously diagnosed for that patient. Main diagnosis groups of controls were: acute digestive surgery 19%, urology 17%, gastroenterology 16% and orthopedic surgery 15%. The study protocol was cleared by the Ethics Committee of the hospital and all individuals gave written informed consent to participate and to perform genetic analysis on their samples. Our study is based on 293 cases (67% of eligible) and 272 controls (63% of eligible) that provided a blood sample to perform the ...

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“…The most common single nucleotide polymorphism is SULT1A1*2 which has a nucleotide change of G to A that causes a change from arginine to histidine at codon 213. This allozyme has lower enzymic activity and thermostability than the wild-type enzyme (Raftogianis et al, 1997;Engelke et al, 2000). An association between genetic polymorphisms of SULT1A1 and cancer susceptibility has been reported (Dalhoff et al, 2005).…”

Section: (Ix) Genetic Variability Of Sulfotransferasementioning

confidence: 99%

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

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Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2

Cited by 62 publications

References 21 publications

SULT1A1 genotype and susceptibility to colorectal cancer

SULT1A1 genotype and susceptibility to colorectal cancer

Polymorphisms in sulfotransferasesSULT1A1 andSULT1A2 are not related to colorectal cancer

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

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