Association between Gastrointestinal Dysfunction Score (GIDS) and disease severity and prognosis in critically ill patients: A prospective, observational study

Li, Xinyan; Wang, Qizhi; Yang, Dandan; Fu, Maoliang; Mi, Yang; Bi, Yang; Wang, Chunting; Xuan, Shi‐Ying

doi:10.1016/j.clnu.2023.03.004

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…FI was the most common complication during enteral feeding in the ICU 39 . The overall FI incidence was 32.5% (53/163) in our study, which was consistent with previous clinical trials 26,27,39 . It is satisfied that administration of sivelestat sodium could significantly reduce the incidence and duration days of FI.…”

Section: Discussionsupporting

confidence: 90%

“…AGI was a frequent complication in critically ill patients, which was definitely associated with worse outcomes 24,26,29 . Critically ill patients had a 40% prevalence of AGI and a 33% fatality rate, according to a meta‐analysis of 14 trials 30 .…”

Section: Discussionmentioning

confidence: 99%

“…GIDS was a new developed five grades scoring system (0–4 points) originating from the previously AGI grading 27 . Liu X and colleagues demonstrated that when compared with patients with GIDS 0–1, those with GIDS 2–4 had larger APACHE II and SOFA scores, longer duration of ICU stay, and higher 28‐day mortality rates 26 . Therefore, we compared the proportions of patients with GIDS ≥2 points between the sivelestat and non‐sivelestat groups.…”

Section: Discussionmentioning

confidence: 99%

“…Acute gastrointestinal injury (AGI) was defined as the condition occurring when the gastrointestinal tract malfunctions as a result of an acute illness 24,25 . The clinical gastrointestinal function was evaluated using the gastrointestinal dysfunction score (GIDS), which was a developed AGI grading system (divided into five grades) 26,27 . FI syndrome was defined as the manifestations of intolerance during enteral feeding for clinical reasons (abdominal distension or pain, diarrhea, bleeding, high gastric residuals, intra‐abdominal hypertension, vomiting, etc.).…”

Section: Methodsmentioning

confidence: 99%

“… 24 , 25 The clinical gastrointestinal function was evaluated using the gastrointestinal dysfunction score (GIDS), which was a developed AGI grading system (divided into five grades). 26 , 27 FI syndrome was defined as the manifestations of intolerance during enteral feeding for clinical reasons (abdominal distension or pain, diarrhea, bleeding, high gastric residuals, intra‐abdominal hypertension, vomiting, etc.). Failure to attain 20 kcal/kg BW/day within 72 h of a feeding effort was taken as evidence of FI.…”

Section: Methodsmentioning

confidence: 99%

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The beneficial effects of neutrophil elastase inhibitor on gastrointestinal dysfunction in sepsis

Sun,

Li,

Deng

et al. 2024

Clinical Translational Sci

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To investigate the effects of neutrophil elastase inhibitor (sivelestat sodium) on gastrointestinal function in sepsis. A reanalysis of the data from previous clinical trials conducted at our center was performed. Septic patients were divided into either the sivelestat group or the non‐sivelestat group. The gastrointestinal dysfunction score (GIDS), feeding intolerance (FI) incidence, serum levels of intestinal barrier function and inflammatory biomarkers were recorded. The clinical severity and outcome variables were also documented. A total of 163 septic patients were included. The proportion of patients with GIDS ≥2 in the sivelestat group was reduced relative to that in the non‐sivelestat group (9.6% vs. 22.5%, p = 0.047) on the 7th day of intensive care unit (ICU) admission. The FI incidence was also remarkably reduced in the sivelestat group in contrast to that in the non‐sivelestat group (21.2% vs. 37.8%, p = 0.034). Furthermore, the sivelestat group had fewer days of FI [4 (3, 4) vs. 5 (4–6), p = 0.008]. The serum levels of d‐lactate (p = 0.033), intestinal fatty acid‐binding protein (p = 0.005), interleukin‐6 (p = 0.001), white blood cells (p = 0.007), C‐reactive protein (p = 0.001), and procalcitonin (p < 0.001) of the sivelestat group were lower than those of the non‐sivelestat group. The sivelestat group also demonstrated longer ICU‐free days [18 (0–22) vs. 13 (0–17), p = 0.004] and ventilator‐free days [22 (1–24) vs. 16 (1–19), p = 0.002] compared with the non‐sivelestat group. In conclusion, sivelestat sodium administration appears to improve gastrointestinal dysfunction, mitigate dysregulated inflammation, and reduce disease severity in septic patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

The beneficial effects of neutrophil elastase inhibitor on gastrointestinal dysfunction in sepsis

Sun,

Li,

Deng

et al. 2024

Clinical Translational Sci

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Comment on: Association between gastrointestinal dysfunction score and disease severity and prognosis in critically ill patients

Kollu

2023

Clinical Nutrition

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Exploration of the molecular mechanism of intercellular communication in paediatric neuroblastoma by single-cell sequencing

Chu

2023

Sci Rep

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Neuroblastoma (NB) is an embryonic tumour that originates in the sympathetic nervous system and occurs most often in infants and children under 2 years of age. Moreover, it is the most common extracranial solid tumour in children. Increasing studies suggest that intercellular communication within the tumour microenvironment is closely related to tumour development. This study aimed to construct a prognosis-related intercellular communication-associated genes model by single-cell sequencing and transcriptome sequencing to predict the prognosis of patients with NB for precise management. Single-cell data from patients with NB were downloaded from the gene expression omnibus database for comprehensive analysis. Furthermore, prognosis-related genes were screened in the TARGET database based on epithelial cell marker genes through a combination of Cox regression and Lasso regression analyses, using GSE62564 and GSE85047 for external validation. The patients’ risk scores were calculated, followed by immune infiltration analysis, drug sensitivity analysis, and enrichment analysis of risk scores, which were conducted for the prognostic model. I used the Lasso regression feature selection algorithm to screen characteristic genes in NB and developed a 21-gene prognostic model. The risk scores were highly correlated with multiple immune cells and common anti-tumour drugs. Furthermore, the risk score was identified as an independent prognostic factor for NB. In this study, I constructed and validated a prognostic signature based on epithelial marker genes, which may provide useful information on the development and prognosis of NB.

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Association between Gastrointestinal Dysfunction Score (GIDS) and disease severity and prognosis in critically ill patients: A prospective, observational study

Cited by 11 publications

References 20 publications

The beneficial effects of neutrophil elastase inhibitor on gastrointestinal dysfunction in sepsis

The beneficial effects of neutrophil elastase inhibitor on gastrointestinal dysfunction in sepsis

Comment on: Association between gastrointestinal dysfunction score and disease severity and prognosis in critically ill patients

Exploration of the molecular mechanism of intercellular communication in paediatric neuroblastoma by single-cell sequencing

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