Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

Jiang, Dong; Zhou, Hao; Guo, Wen; Xu, Pengcheng; Yin, Chang; Wen, Shuzheng; Wang, Jihong

doi:10.1186/s13018-016-0436-4

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…On the one hand, previous literatures have said that GDF 5 rs143383 polymorphisms C allele is a protective factor for the susceptibility of knee osteoarthritis among Caucasian populations (OR=0.74, P<0.001) and Asian populations (OR=0.87, P=0.004) [9]. On the other hand, Sujie Zhang et al holds that interaction GDF 5 rs143383 polymorphisms T allele increases the risk of knee osteoarthritis among Asian (OR=1.62, P<0.001) [5].…”

Section: Discussionmentioning

confidence: 97%

“…Their limitations still remain. Firstly, Feng Pan's meta-analysis has some shortcomings, including unmatching HWE studies in their meta-analysis [9], which results are unreliable. Secondly, Xin Huang's meta-analysis explores the association between all kinds of osteoarthritis and GDF 5 rs143383 polymorphisms, which can't precisely describe the relationship between GDF 5 rs143383 polymorphisms and the susceptibility of knee osteoarthritis [12].…”

Section: Discussionmentioning

confidence: 99%

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Association between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis among Caucasian But Not Asian: A Meta-analysis

Lei¹,

Jiang²,

et al. 2020

Preprint

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Background A few months ago, the Bioscience Reports journal showed that Growth Differentiation Factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang library. The meta-analysis was completed by STATA 18.0 software. Two independent authors extracted the data and assessed case-control trial quality. Results A total of 196 studies were collected, 16 of them including in final meta-analysis (7997 cases and 12684 controls). There was significant association between GDF 5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76-0.91); dominate model (CC+CT versus TT): OR = 0.80(95% CI = (0.72-0.90); recessive model (CC versus CT+TT): OR= 0.79 (95% CI = 0.68-0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI=0.80-0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI=0.60-0.85). In the subgroup analysis by ethnicity, we obtained the results is no significant among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Association between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis among Caucasian But Not Asian: A Meta-analysis

Lei¹,

Jiang²,

et al. 2020

Preprint

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“…Although the association of the risk of knee osteoarthritis and GDF5 rs143383 genetic polymorphisms has been described in several meta-analyses [8][9][10][11][12], several recent trials also reported the risk of knee osteoarthritis and GDF5 rs143383 genetic polymorphisms [4][5][6]. On the other hand, prior meta-analyses have some limitations, such as low quality and lacking enough studies.…”

Section: Introductionmentioning

confidence: 99%

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Peng

Jin

et al. 2020

Arthritis Res Ther

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Background A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang library. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software. Results A total of 196 studies were collected, 16 of them included in final meta-analysis (7997 cases and 12,684 controls). There was significant association between GDF5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76–0.91); dominate model (CC+CT versus TT): OR = 0.80 (95% CI = 0.72–0.90); recessive model (CC versus CT+TT): OR = 0.79 (95% CI = 0.68–0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI = 0.80–0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI = 0.60–0.85)). In the subgroup analysis, we obtained the results that there is no significance among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

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“…Bone morphogenetic protein-14 (BMP-14), also known as growth and differentiation factor-5 (GDF5), is one of the most frequently studied targets for OA onset. [ 10 , 11 ] Belonging to the transforming growth factor-β family, it is closely associated with BMPs, [ 12 ] and affects the development, maintenance, and repair of cartilage, bone, and other tissues of synovial joint. [ 13 – 17 ] BMP-14 is involved in chondrogenesis and joint formation, and mutations in its coding gene can lead to diseases, for example, chondrodysplasias.…”

Section: Introductionmentioning

confidence: 99%

Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis

Wang

2017

Medicine

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Background:Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis.Methods:Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang. The strength of correlations was examined with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were carried out. All statistical analyses were performed with STATA software (version 12.0).Results:Overall, BMP-14 rs143383 polymorphism was negatively correlated with the susceptibility to knee OA and hand OA under genetic contrasts of CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T, TC versus TT (OR = 0.71, 95% CI = 0.65–0.79; OR = 0.81, 95% CI = 0.73–0.89; OR = 0.79, 95% CI = 0.71–0.86; OR = 0.85, 95% CI = 0.81–0.90; OR = 0.84, 95% CI = 0.75–0.93), and TC versus TT, CC versus TT + TC, C versus T (OR = 0.76, 95% CI = 0.65–0.89; OR = 0.79, 95% CI = 0.68–0.92; OR = 0.90, 95% CI = 0.85–0.95), respectively; similar results were observed in subgroups after stratification analyses. Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity.Conclusion:BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence.

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Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

Cited by 13 publications

References 34 publications

Association between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis among Caucasian But Not Asian: A Meta-analysis

Association between Growth Differentiation Factor 5 rs143383 Genetic Polymorphism and the Risk of Knee Osteoarthritis among Caucasian But Not Asian: A Meta-analysis

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis

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