Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis

Abstract

Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α −899C/T, IL-1β −511C/T and IL-1β +3953C/T; IL-6 −174G/C and −572C/G; IL-10 −819C/T and −1082A/G; IL-18 −607C/A and −137G/C). Our result showed that IL-1α −899C/T and IL-18 −607C/A (under all the genetic models), and IL-6 −572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (P<0.05). Subgroup analysis by ethnicity showed that IL-6 −174G/C polymorphism (under all the five models) and IL-10 −1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α −899C/T, IL-6 −572C/G and IL-18 −607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.

Interleukin‐10 negatively modulates extracellular signal‐regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion

“…Interleukin 10 (IL‐10) works as an immunoregulatory cytokine in several pathologies . Its use has been proposed for the treatment of neoplasia, prevention of stroke and in pathological conditions involving chronic inflammation .…”

Influence of interleukin-1β gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke

“…IL is an important pro-inflammatory factor playing an important role in ischemic brain injury ( 10 , 11 ). It has been proved in studies that IL-1 gene polymorphism has a certain correlation with cerebral infarction ( 12 , 13 ). IL-1 family members include IL-1α, IL-1β and IL-1Ra, the first two of which can be involved in the senescence of vascular endothelial cells and inflammatory response of hypoxic-ischemic brain injury, thereby affecting the function of vascular endothelial cells and atherosclerosis process ( 14 ).…”

Association of interleukin-6 gene polymorphism with susceptibility, neurological deficit and recurrence risk of cerebral infarction

“…23 The relationship between -572C/G polymorphism and CI is controversial. There was a meta-analysis by Wang et al 24 with 2,547 patients and 3,958 controls, the conclusion of which is that the -572C/G polymorphic status is related to CI. However, another meta-analysis reported that the -572C/G polymorphic status may not be associated with change in CI risk.…”