Association between genetic variants of <i><scp>microRNA</scp>‐21</i> and <i><scp>microRNA</scp>‐155</i> and systemic lupus erythematosus: A case‐control study from a Chinese population

Wang, Rong; Wei, Anji; Zhang, Yingjie; Xu, Guidan; Nong, Xuejuan; Liu, Chunhong; Zeng, Yonglong; Huang, Hua‐Tuo; Pang, Xiao-xia; Wei, Wujun; Wang, Chunfang; Huang, Huayi

doi:10.1002/jcla.24518

Cited by 8 publications

(3 citation statements)

References 63 publications

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“…The current results consistent with previous research investigating the association between rs767649 A>T and susceptibility to MS, as well as to other autoimmune diseases [18,19]. The TT genotype and T allele of rs767649A>T were correlated with elevated expression levels of miR-155 in non-small cell lung cancer and hepatocellular carcinoma, in addition to influencing the miR-155 up regulation in many processes connected to the pathogenesis of MS [20,21]. Based on that, the findings of the current investigation could be comprehend through that, rs767649A>T mutant allele may cause elevation in miR-155 expression, consequently, leading to increase susceptibility to MS.…”

Section: Discussionsupporting

confidence: 92%

Impact of miR-155 Gene Polymorphism (rs767649 A>T) and miR-155 Gene Expression on Susceptibility to Multiple Sclerosis

Ali,

Mohammed

2024

amj

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Background: Micro RNA155 (miR-155) was identified as an essential determinant in immunological responses, and its genetic variants have increasing attention due to their ability to modulate its expression and potentially influence the susceptibility to autoimmune illnesses including rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, etc. Objectives: To examine the impact of miR-155 gene polymorphism (rs767649A>T) and miR-155 gene expression and their association with multiple sclerosis (MS) in a sample of Iraqi patients. Materials and methods: A total of 75 blood specimens were obtained from individuals diagnosed with MS. While an additional 75 blood specimens were collected from evidently healthy participants serving as a control group, with an age ranged 20-71 years. miR-155 gene polymorphism (rs767649 A>T) was determined utilizing Tetra-ARMS Polymerase Chain Reaction (Tetra-ARMS PCR) and miR-155 expression was evaluated using Real-time Polymerase Chain Reaction (RT-PCR). Results: The females experienced MS at a higher rate (69.33%) compared to the males. Furthermore, the age group 30-39 years showed a greater susceptibility to the disease (54.67%). The analysis of miR-155 (rs767649 A>T) SNP in MS patients indicated that 7 (9.34%) had the wild genotype (AA), 31 (41.33%) had the heterogeneous genotype (AT), and 37 (49.33%) had the mutant genotype (TT). These differences were statistically significant (P-value = 0.040). A allele frequency was 45 (0.3) (OR: 0.25; CI: 0.15-0.41) and T allele frequency was 105 (0.7) (OR: 3.91; CI: 2.42-6.33) in MS patients. While analysis of miR-155 gene expression demonstrated a significant increase in the patient group (1.82 ± 0.25 fold) compared to the healthy control group (0.33 ± 0.13 fold). The relationship between miR-155 gene expression and miR-155 genotypes in MS patients, revealed a notable elevation in miR-155 gene expression at the TT genotype (3.15 ± 0.73 fold), followed by TA genotype (1.29 ±0.65fold) and finally AA genotype (0.37 ± 0.19 fold) with highly statistically significant difference (P-value = 0.001). Conclusion: There was a significant positive correlation between miR-155 (rs767649 A>T) genotypes and miR-155 expression and susceptibility to MS in Iraqi patients. These findings suggests that miR-155 may hold potential as a diagnostic and therapeutic marker for the disease.

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Section: Discussionsupporting

confidence: 92%

Impact of miR-155 Gene Polymorphism (rs767649 A>T) and miR-155 Gene Expression on Susceptibility to Multiple Sclerosis

Ali,

Mohammed

2024

amj

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“…Studies have found elevated expression levels of microRNA-21 and miR-155 in SLE patients, which are correlated with disease activity and clinical severity. [ 74 , 75 ] MiR-155, through regulating the expression of multiple immune-related genes, influences the differentiation, function, and inflammatory response of immune cells, thereby participating in the pathogenesis of autoimmune diseases. [ 76 ] Therefore, inhibiting the expression of microRNA-21 and microRNA-25 or using microRNA-21 and microRNA-25 antagonists may help alleviate inflammation and immune reactions in SLE.…”

Section: Discussionmentioning

confidence: 99%

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: A bibliometric analysis from 2012 to 2022

Gao,

Huang,

Wang

et al. 2023

Medicine

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Background: Recent studies have shown substantial progress in understanding the association between epigenetics and autoimmune diseases. However, there is a lack of comprehensive bibliometric analysis in this research area. This article aims to present the current status and hot topics of epigenetic research in autoimmune diseases (ADs) from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs. Methods: This study collected 1870 epigenetic records related to autoimmune diseases from the web of science core collection database, spanning from 2012 to 2022. Analysis of regions, institutions, journals, authors, and keywords was conducted using CiteSpace, VOSviewer, and the R package “bibliometrix” to predict the latest trends in epigenetic research relevant to autoimmune diseases. Results: The number of epigenetic publications related to autoimmune diseases has been increasing annually. The United States has played a major role in this field, contributing over 45.9% of publications and leading in terms of publication volume and citation counts. Central South University emerged as the most active institution, contributing the highest number of publications. Frontiers in Immunology is the most popular journal in this field, publishing the most articles, while the Journal of Autoimmunity is the most co-cited journal. Lu QJ is the most prolific author, and Zhao M is the most frequently co-cited author. “Immunology” serves as a broad representative of epigenetic research in ADs. Hot topics in the field of epigenetic modifications associated with autoimmune diseases include “regulatory T cells (Treg),” “rheumatoid arthritis,” “epigenetic regulation,” “cAMPresponsive element modulator alpha,” “cell-specific enhancer,” “genetic susceptibility,” and “systemic lupus erythematosus.” Furthermore, the study discusses the frontiers and existing issues of epigenetic modifications in the development of autoimmune diseases. Conclusions: This study provides a comprehensive overview of the knowledge structure and developmental trends in epigenetic research related to autoimmune diseases over the past 11 years.

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“…Studies have found elevated expression levels of microRNA-21 and miR-155 in SLE patients, which are correlated with disease activity and clinical severity. [74][75] MiR-155, through regulating the expression of multiple immune-related genes, influences the differentiation, function, and inflammatory response of immune cells, thereby participating in the pathogenesis of autoimmune diseases. [76] Therefore, inhibiting the expression of microRNA-21 and microRNA-25 or using microRNA-21 and microRNA-25 antagonists may help alleviate inflammation and immune reactions in systemic lupus erythematosus.…”

Section: Research Frontiers and Future Trends Of Epigenetic Modificat...mentioning

confidence: 99%

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: a bibliometric analysis from 2012 to 2022

Gao

Huang

Wang

et al. 2023

Preprint

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Background Epigenetics plays a significant role in the pathogenesis of autoimmune diseases (ADs) and has garnered considerable attention in related research fields. Recent studies have shown substantial progress in understanding the association between epigenetics and autoimmune diseases. However, there is a lack of comprehensive bibliometric analysis in this research area. Objective This article aims to present the current status and hot topics of epigenetic research in ADs from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs. Methods This study collected 1,870 epigenetic records related to autoimmune diseases from the Web of Science Core Collection (WoSCC) database, spanning from 2012 to 2021. Analysis of regions, institutions, journals, authors, and keywords was conducted using CiteSpace, VOSviewer, and the R package "bibliometrix" to predict the latest trends in epigenetic research relevant to autoimmune diseases. Results The number of epigenetic publications related to autoimmune diseases has been increasing annually. The United States has played a major role in this field, contributing over 45.9% of publications and leading in terms of publication volume and citation counts. Central South University emerged as the most active institution, contributing the highest number of publications. Frontiers in Immunology is the most popular journal in this field, publishing the most articles, while the Journal of Autoimmunity is the most co-cited journal. Lu QJ is the most prolific author, and Zhao M is the most frequently co-cited author. "Immunology" serves as a broad representative of epigenetic research in ADs. Hot topics in the field of epigenetic modifications associated with autoimmune diseases include "regulatory T cells (Treg)," "rheumatoid arthritis," "epigenetic regulation," "cAMP-responsive element modulator alpha," "cell-specific enhancer," "genetic susceptibility," and "systemic lupus erythematosus." Furthermore, the study discusses the frontiers and existing issues of epigenetic modifications in the development of autoimmune diseases. Conclusion This study provides a comprehensive overview of the knowledge structure and developmental trends in epigenetic research related to autoimmune diseases over the past 11 years. The research findings summarize and clarify the forefront and future trends in studying the association between epigenetics and autoimmune diseases, serving as a reference for scholars engaged in exploring the relationship between epigenetics and autoimmune diseases .

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Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 8 publications

References 63 publications

Impact of miR-155 Gene Polymorphism (rs767649 A>T) and miR-155 Gene Expression on Susceptibility to Multiple Sclerosis

Impact of miR-155 Gene Polymorphism (rs767649 A>T) and miR-155 Gene Expression on Susceptibility to Multiple Sclerosis

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: A bibliometric analysis from 2012 to 2022

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: a bibliometric analysis from 2012 to 2022

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