Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women

Jacyntho, Cláudia; Giraldo, Paulo César; Horta, Antônio A.; Grandelle, Rosana; Gonçalves, Ana Katherine; Fonseca, Thaís C. O.; Eleutério, José

doi:10.1016/j.ajog.2011.03.011

Cited by 28 publications

(52 citation statements)

References 17 publications

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“…Research show that the risk of HPV anal lesions in women with HPV cervical lesions is high (1,2,4,5,(8)(9)(10)(11)(12)14) . Genital infection by HPV is the main predictor for anal infection, and a significant correlation has been found between the types of HPV identified in anal lesions and those found in cervical lesions (2) .…”

Section: Resultsmentioning

confidence: 99%

“…The authors reported that the risk of women with cervical HPV infection developing anal infection is higher among women without precedent infections. In turn, a cross-sectional study with 260 Brazilian women (184 with GSIL and 76 without it) (11) showed that history of more than 4 anal sexual relations per year and presence of genital herpes were risk factors for the emergence of ASIL. The study also showed that the prevalence of ASIL in women with GSIL was significantly higher than in women without the lesions (17.4% against 2.6%).…”

Section: Dst -J Bras Doenças Sex Transm 2013;25(3):145-149mentioning

confidence: 99%

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Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Filho¹,

Eleutério²,

Dias³

et al. 2013

J Bras Doenças Sex Transm

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Introduction: There seems to be a fairly close relationship between genital and anal lesions associated with human papillomavirus (HPV) and with the pathogenesis of malignancies in such sites. Objective: This review seeks to analyze published papers that suggest the necessity for anal intraepithelial lesions screening in women with HPV genital intraepithelial lesions. Methods: A systematic review of original research published between 2001 and 2014 was performed in the databases PubMed, HighWire, Cochrane Library and Google Scholar. The keywords for the search were: "screening" or "early detection of cancer" and "anus" or "anus diseases" or "neoplasms anus" and "woman" or "women" and "HPV" or "DNA probes, HPV". Results: 1,203 articles were selected in the first search. After the reviewers applied exclusion and inclusion criteria and analyzed the papers, 15 were selected to compose this review. Most of them showed higher rates of anal intraepithelial lesions in women with genital intraepithelial lesions than in regular women. We also found a correlation between genital neoplasms and anal infection by oncogenic HPV types and the role of the virus in the pathogenesis of anal cancer. Conclusion: Screening for anal lesions in women with HPV genital lesions should be indicated, and further studies are required to determine the best methods.

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Section: Resultsmentioning

confidence: 99%

Section: Dst -J Bras Doenças Sex Transm 2013;25(3):145-149mentioning

confidence: 99%

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Filho¹,

Eleutério²,

Dias³

et al. 2013

J Bras Doenças Sex Transm

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show abstract

“…However, none of the studies performed random biopsy: only HRA-guided biopsy. 22,77,79,122 Of these, only Santoso calculated performance statistics. As mentioned previously, Santoso et al 77 compared anal cytology and HRA to histologic results in women with LGTN.…”

Section: Anal Cancer Screening Methods: Strengths and Limitationsmentioning

confidence: 99%

“…Jacyntho et al . 22 evaluated 76 healthy women recruited from a clinic in Brazil who presented for cervical cancer screening. Healthy controls had at least 2 recent normal cervical cytology tests (interval not described) and normal genitoscopy.…”

Section: Anal Hpv Infection and Disease In Womenmentioning

confidence: 99%

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Screening for Anal Cancer in Women

Moscicki

Darragh

Berry-Lawhorn

et al. 2015

Journal of Lower Genital Tract Disease

135

122

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Objective The incidence of anal cancer is higher in women than men in the general population and has been increasing for several decades. Similar to cervical cancer, most anal cancers are associated with human papillomavirus (HPV) and it is believed that anal cancers are preceded by anal high-grade squamous intraepithelial lesions (HSIL). Our goal was to summarize the literature on anal cancer, HSIL and HPV infection in women, and provide screening recommendations in women. Methods A group of experts convened by the ASCCP and the International Anal Neoplasia Society reviewed the literature on anal HPV infection, anal SIL and anal cancer in women. Results Anal HPV infection is common in women but is relatively transient in most. The risk of anal HSIL and cancer varies considerably by risk group, with HIV-infected women and those with a history of lower genital tract neoplasia (LGTN) at highest risk compared with the general population. Conclusions While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and have digital anorectal examinations to detect anal cancers. HIV-infected women and women with LGTN, may be considered for screening with anal cytology with triage to treatment if HSIL is diagnosed. Healthy women with no known risk factors or anal cancer symptoms do not need to be routinely screened for anal cancer or anal HSIL.

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Liquid‐based cytology and HPV DNA testing using intra‐anal specimens from HIV‐negative women with and without genital HPV‐induced lesions

Eleutério

Benício

Giraldo

et al. 2014

Diagnostic Cytopathology

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Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women

Cited by 28 publications

References 17 publications

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Screening for Anal Cancer in Women

Liquid‐based cytology and HPV DNA testing using intra‐anal specimens from HIV‐negative women with and without genital HPV‐induced lesions

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