Association between genital mycoplasmas infection and human papillomavirus infection, abnormal cervical cytopathology, and cervical cancer: a systematic review and meta-analysis

Ye, Hui; Song, Tiange; Zeng, Xi; Li, Lin; Hou, Minmin; Xi, Mingrong

doi:10.1007/s00404-018-4733-5

Cited by 45 publications

(53 citation statements)

References 41 publications

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“…Among them, the Ureaplasma parvum and their related taxa manifested higher richness in the baseline HPV-positive group compared with the baseline HPVnegative group. This is consistent with previous studies in different populations of the world indicating that Ureaplasma parvum was associated with a significantly increased risk of overall HPV infection and increased risk of abnormal cervical cytopathology (20)(21)(22). It was reported that the infection of Ureaplasma could lead to scarring and damage of the epithelium (23), suggesting that infection of the reproductive tract with Ureaplasma parvum might also increase the risk of HPV infection by facilitating viral infections.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women

Enqi

Zheng

et al. 2019

Cancer Prevention Research

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The aim of this study was to investigate the associations between cervical microbiota and different human papillomavirus (HPV) infection statuses in cytologically normal women. The cervical microbiota of HPVpositive or -negative women with a normal cytologic diagnosis was characterized and compared using 16S rDNA-based high-throughput sequencing, and the differences in cervical microbiota associated with new acquisition, persistence, and clearances of HPV genotypes were analyzed via one-year follow-up. The results showed that the cervical microbial richness of HPVpositive women was lower than for HPV-negative women, and the difference was more significant in the postmenopausal group relative to the premenopausal group. Ureaplasma parvum and related taxa were associated with baseline HPV positivity, while Brochothrix, Diplorickettsia, Ezakiella, Faecalibacterium, and Fusobacterium genera and their related taxa and Pseudomonas aeruginosa were associated with baseline HPV negativity. For HPV-positive women, the baseline abundance of Actinomyces was negatively associated with new HPV infection, Alloprevotella tannerae, Prevotella nigrescens, and Prevotella oulorum; and Dialister invisus were positively associated with new HPV-type infection within the year of follow-up. Lactobacillus delbrueckii was found to be negatively associated with persistent HPV infection and 9 taxa belonging to Prevotella, Dialister, and Lachnospiraceae were found to be positively associated with persistence, and/or negatively associated with clearance of HPV types. We also observed 10 novel taxa associated with the clearance/persistence of HPV that had not been reported elsewhere. Those taxa associated with different infection statuses of HPV could be used as a biomarker to help predict the risk of developing persistent HPV infection.

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Section: Discussionsupporting

confidence: 92%

Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women

Enqi

Zheng

et al. 2019

Cancer Prevention Research

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“…Induction of HPV in this way is particularly interesting based on the association between Mycoplasma and cervical lesions. Infection with M. genitalium increases the rate of infection with an HPV genotype associated with a high-risk of developing cervical cancer [35]. Recent work has shown that mycoplasma also increases the risk of development of cervical lesions, supporting the association we report in this study [35].…”

Section: Discussionsupporting

confidence: 90%

“…Infection with M. genitalium increases the rate of infection with an HPV genotype associated with a high-risk of developing cervical cancer [35]. Recent work has shown that mycoplasma also increases the risk of development of cervical lesions, supporting the association we report in this study [35]. Mycoplasma can establish persistent, intracellular infections in epithelia cells, which may lead to bacterial vaginosis and/or cervicitis.…”

Section: Discussionsupporting

confidence: 88%

The Relationship Between the Cervical Microbiome, HIV Status, and Pre-Cancerous Lesions

Klein

Kahesa

Mwaiselage

et al. 2018

Preprint

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Nearly all cervical cancers are causally associated with Human Papillomavirus (HPV). The burden of HPV-associated dysplasias in Sub-Saharan Africa is influenced by HIV. To investigate the role of the bacterial microbiome in cervical dysplasia, cytobrush samples were collected directly from cervical lesions of 144 Tanzanian women. The V4 hypervariable region of the 16S rRNA gene was amplified and deep-sequenced. Alpha diversity metrics; Chao1, PD whole tree, and operational taxonomic Unit (OTU) estimates, displayed significantly higher bacterial richness in HIV positive patients (P = 0.01) than in HIV negative patients. Within HIV positive patients, there was higher bacterial richness in patients with high grade squamous intraepithelial lesions (HSIL; P = 0.13) than those without lesions. The most abundant OTUs associated with high-grade squamous intraepitheilal lesions (HSIL) were Mycoplasmatales, Pseudomonadales, and Staphylococcus. We suggest that a chronic mycoplasma infection of the cervix can contribute to HPV-dependent dysplasia by sustained inflammatory signals. IntroductionHuman Papillomavirus (HPV) is the causative agent responsible for 99% of cervical cancers [1].HPV contributes to about 4.8% of all cancers [1]. The disease burden of HPV is most dramatic in developing regions of the world, with HPV being attributed to 14.2% of cancers in Sub-Saharan Africa [1]. Cervical cancer disproportionately affects Sub-Saharan Africa, where 9% of the world's female population over 15 years old accounts for 14% of the world's incident cervical cancer and 18% of cervical cancer-related deaths [2]. The current study uses cervical swab samples obtained from Tanzania, which has among the highest cervical cancer mortality rates by country. Sub-Saharan Affrica also has among the highest HIV rates in the world. The association between HIV and cervical cancer has been better studied than any other factor associated with HPV-related cancers. HIV infection has been strongly linked to increased risk of infection with HPV, and the severity of HPV pathogenesis [3][4][5]. HR HPV genotypes are more prevalent in HIV+ women, suggesting HIV infection provides an environment where these highrisk HPV's can better establish infection and replicate [6]. A likely factor in this is a decrease in T-cell surveillance, which results in an increase in HPV replication with decreasing CD4+ cell count, and other changes in the cervical immune microenvironment as HIV infection progresses.Multiple studies have shown an increase in HPV detection, cervical intraepithelial neoplasms in K l e i n e t a l Demographic Data CollectionAll study participants who gave informed consent and were evaluated by study clinicians. A set of pre-tested, standardized questionnaires were used to gather demographic data. All personal identifiers were removed from samples to ensure patient confidentiality. With patients' permission, medical history was retrospectively retrieved from hospital medical records. Over 30 variables were identified and assessed in the questionn...

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“…Роль ХЦ как ко-фактора при раке шейки матки доволь-но существенна. Исcледователи отметили положительную связь между воспалением шейки матки и плоскоклеточными интраэпителиальными поражениями [17,18].…”

Section: впч-инфекция цервицит и рак шейки маткиunclassified

Cervicitis: an Unresolved Gynecological Problem

Bebneva¹,

Оразов²,

Kostin³

2018

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Association between genital mycoplasmas infection and human papillomavirus infection, abnormal cervical cytopathology, and cervical cancer: a systematic review and meta-analysis

Abstract: We found that U. urealyticum and M. genitalium may increase the risk of high-risk HPV infection, while U. urealyticum, U. parvum, and M. hominis may increase the risk of abnormal cervical cytopathology.

Cited by 45 publications

References 41 publications

Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women

Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women

The Relationship Between the Cervical Microbiome, HIV Status, and Pre-Cancerous Lesions

Cervicitis: an Unresolved Gynecological Problem

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