Association Between Gingival Crevicular Fluid Leptin Levels and Periodontal Status – A Biochemical Study on Indian Patients

Leptin regulates OPG and RANKL expression in Gingival Fibroblasts and Tissues of Chronic Periodontitis Patients

“…Further studies with larger sample sizes are required to explore this fully. In addition, results of the correlation analysis of leptin, OPG, and RANKL with the periodontal clinical indicators was also consistent with the previously reported results 6 , 22 .…”

“…Few studies have investigated the relationship between leptin and chronic periodontitis. Of note, concentrations of leptin in the saliva and the gingival crevicular fluid of chronic periodontitis patients were significantly lower than those in healthy individuals [5,6]. Another study showed that leptin levels in gingival tissues decrease as the periodontal pocket deepens [7].…”

Investigation of leptin levels in periodontal wound healing: A preliminary study

“…There was a raise in the gingival crevicular fluid leptin concentration from baseline value of 258.91 pg/ml to 366.13 pg/ml. [15][16][17]31] This shows that there is a statistically significant (p < 0.05) raise in leptin levels between the baseline and non-surgical periodontal treatment. The results of our study are in accordance with several authors who have studied the role of leptin in periodontal health and disease and effect of periodontal treatment on leptin.…”

“…[14] It has been found that the concentrations of leptin are higher in healthy periodontal tissues and its level declines as periodontal disease progresses, suggesting that leptin plays an important role in immune defense mechanism of the host and is a protective molecule which helps in maintaining tissue homeostasis. [14][15][16][17] There is an accumulating substantiation that leptin plays a key role in the regulation of wound healing and repair by aiding the wound closure through promoting angiogenesis [9,18,19] reepithelization (mitogenesis of keratinocytes), [20] induction of keratinization, [21] as well as fibroblast proliferation and collagen synthesis. [22] The accumulating evidence have proven beyond doubt that leptin is necessary to orchestrate the major events involved in the biological process of wound.…”

Leptin levels in gingival crevicular fluid during canine retraction: in vivo comparative study

“…Leptin is a 16 kDa circulating protein and polypeptide hormone which is derived from adipocytes and has been upgraded to the status of a cytokine in recent years. It is postulated that leptin manipulates the response of the host to various inflammatory stimuli, as it simultaneously increases cytokine production and phagocytosis (Selvarajan et al, 2015). Leptin is known to have a role in protecting gingival tissues (Karthikeyan and Pradeep, 2007a, 2007b).…”