Association between GSTM1 and GSTT1 Allelic Variants and Head and Neck Squamous Cell Cancinoma

Abstract

Backgrounds GSTM1 and GSTT1 are involved in the detoxification of carcinogens such as smoking by-products, and polymorphisms in these two genes with a result of loss of enzyme activity may increase risk of carcinogenesis. Although many epidemiological studies have investigated the association between GSTM1 or GSTT1 null genotype and head and neck squamous cell carcinoma (HNSCC), the results remain conflicting. To elucidate the overall association of GSTM1, GSTT1 and HNSCC, we included all available studies and performed this meta-analysis.Methodology/Principal FindingsA dataset including 42 articles for GSTM1, 32 articles for GSTT1, and 15 articles for GSTM1 and GSTT1 in combination were identified by a search in PubMed. Associations beween HNSCC and polymorphisms of GSTM1 and GSTT1 alone and in combination were analysed by software RevMan 5.1. Stratification analysis on ethnicity and smoking status, sensitivity analysis, heterogeneity among studies and their publication bias were also tested. Association was found in overall analysis between HNSCC and GSTM1 and GSTT1 null genotype. Stratified by ethnicity, we found increased risks of HNSCC in carriers with GSTM1 null genotype in Asian, GSTT1 null genotype in South American, and dual null genotype in European and Asian. When stratified by smoking, a more significant association of GSTM1 null genotype with HNSCC risk was observed in smokers.Conclusions/SignificanceThis meta-analysis presented additional evidence of the association between GSTM1 and GSTT1 polymorphisms and HNSCC risk.

Gene–environment interaction and susceptibility in head and neck cancer patients and in their first‐degree relatives: a study of Northeast Indian population

“…Our previous study conducted on oral squamous cell carcinoma also showed a possible role of GSTM1 and GSTT1 null genotypes (18). A meta-analysis also revealed the association between GSTM1 and GSTT1 polymorphisms and HNSCC risk (16). Our present study further provided strong evidence that GSTM1 and GSTT1 null genotypes increased the susceptibility to head and neck cancer.…”

CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta-analysis

“…Therefore, interindividual differences in expression of SNPs may contribute to the variability in the risk towards various types of malignancies, including OSCC. Currently, the published evidence shows that there were significant associations of gene polymorphisms with the susceptibility of numerous cancers, such as GST and CYP1A1 gene polymorphisms with squamous cell carcinoma of the lungs and head and neck cancer, and the 8q24 rsl3281615 polymorphism with the risk of breast cancer (10)(11)(12)(13)(14)(15). However, the associations of OSCC with CYP1A1 MspI genetic variants are inconsistent (16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Phenotypic expression and polymorphism of Glutathione S Transferase gene in materno-fetal dyads with idiopathic fetal growth restriction

“…9,10 The prevalence in other countries was reportedly much higher in the range of 40e60 % that includes 47% in Japanese, 11 58.3% in Chinese, 12 60.2% in Koreans, 13 and 53.1% in European population. 14 The frequency of GSTM1 null genotype in IFGR fetus and their mothers in this study was about 40%. Significantly high prevalence of GSTM1 null genotype was observed in IFGR fetus as compared to controls that indicates GSTM1 null genotype were 3 times more vulnerable towards development of IFGR.…”