Association between gut microbiota and erectile dysfunction: a two-sample Mendelian randomization study

Abstract

Objective: Several observational studies have recently been reported to suggest an association between gut microbiotaand erectile dysfunction（ED）. However, the causal relationship between gut microbiota and erectile dysfunction remains unclear. Therefore, the aim of this study was to clearly elaborate the causal relationship between gut microbes and erectile dysfunction. Methods: A two-sample Mendelian randomization study was conducted with summary statistics of the gut microbiota from the largest genome-wide association study Meta-analysis conductedby the MiBiogen Consortium (n=13, 266). ED patients’ information was collected from the European ancestry (6175 cases vs 217,630 controls). The causal relation between gut microbiota and ED was investigated using inverse variance weighting (IVW), MR-Egger, weighted median, weighted model, and MR-PRESSO. Reverse Mendelian randomization（MR） analysis was performed on bacteria found to be causally involved in erectile dysfunction in forward Mendelian random analysis. Cochran's Q statistic was employed to quantify the heterogeneity of instrumental variables. Results: IVW estimate indicates that Lachnospiraceae(OR=1.26, 95%CI=1.06 to 1.5, P=0.008), Oscillibacter(OR=1.2, 95%CI=1.04 to 1.39, P=0.016), Tyzzerella3(OR=1.14, 95%CI=1.02 to 1.27, P=0.024) and Erysipelotrichaceae UCG003(OR=2.05, 95%CI=1.54 to 2.56, P=0.006) were risk factor for ED. Sensitivity analyses were performed to verify the causal relations obtained by MR. The results of Cochran’s IVW Q test showed no significant heterogeneity of these IVs. Based on the results of the inverse MR analysis, no obvious causal effect of ED on intestinal flora was found. There was no significant heterogeneity found for instrumental variables or horizontal pleiotropy. Conclusions: This two-sample MR study found that gut microbes including family Lachnospiraceae、genus Erysipelotrichaceae UCG003、genus Oscillibacter、genus Tyzzerella3 were causally associated with ED. Further studies are needed to clarify the mechanism of gut microbes’s pathogenesis role in ED.

Interactive effects of Composite Dietary Antioxidant Index with Body Mass Index for the risk of stroke among U.S. adults: insight from NHANES 2001–2018

“…Wang et al (10) also reported a negative correlation, with their fully adjusted model indicating an OR of 0.97 (95% CI 0.95-0.99) and a 23% decrease in stroke incidence in the highest CDAI quartile versus the lowest (OR 0.77, 95% CI 0.64-0.92). Chen et al (11) found that each unit increase in CDAI reduced stroke risk by 3.4% (OR 0.966, 95% CI 0.937-0.997), collectively affirming the association between higher dietary antioxidant intake and reduced stroke risk. These findings collectively affirm the link between higher dietary antioxidant intake and reduced stroke risk.…”

“…Conversely, a study by Hantikainen et al (9) which also used NEAC to assess dietary antioxidant intake, found no link between a highantioxidant diet and stroke risk. At the same time, a number of recent studies have further analyzed the association between CDAI and stroke by using CDAI as a measure of dietary antioxidant intake, and found that there is a nonlinear association between CDAI and stroke (10)(11)(12)(13).…”

Association of methyl donor nutrients dietary intake and sleep disorders in the elderly revealed by the intestinal microbiome

“…For instance, the increase in Actinomyces is often disclosed in infections with inflammation-related diseases 54 and can be causally related to accelerated age of biological senescence according to a recent study. 55 Eisenbergiella have also been recognized as a proinflammatory microorganism, manifested by the higher c-reactive protein, and increased release of inflammatory mediators from immune cells. 56,57 The opportunistic pathogenic bacteria, Peptoniphilus is often considered a major pathogen in various infections, especially chronic wounds such as diabetic foot ulcers and chronic compression, 58 and are associated with energy metabolism through the production of shortchain fatty acids (SCFAs) like butyrate.…”

Diffusion Idiopathic Skeletal Hyperostosis (DISH), a Link between Gut Microbiota and Spinal Degenerative Diseases<strong> </strong>

“…Gut inflammation can result in systemic inflammation, which affects various parts of the body. Systemic inflammation has been linked to a range of chronic health conditions, including those related to spinal health [121].…”

“…Lumbar spinal stenosis is a medical condition characterized by the narrowing of the spinal canal in the lower back, leading to a range of symptoms and discomfort. The burgeoning research in this field aims to shed light on how factors related to gut health might influence the development and progression of lumbar spinal stenosis [121,136].…”