Association between gut microbiota and seven gastrointestinal diseases: A Mendelian randomized study

Abstract

BackgroundObservational research has shed light on the ability of gut microbes to influence the onset and progression of gastrointestinal diseases. The causal relationships between specific gut microbiomes and various gastrointestinal conditions, however, remain unknown.MethodsWe investigated the relationship between gut microbiota and seven specific gastrointestinal disorders using a robust two‐sample Mendelian randomization (MR) approach. The inverse variance‐weighted (IVW) method was used as the primary analysis tool in our study. Furthermore, we conducted multiple sensitivity analyses to strengthen the robustness of our findings and ensure the reliability of the IVW method.ResultsOur research has discovered significant links between the composition of gut microbiota and a variety of gastrointestinal ailments. We found compelling links between 13 gut microbiota and fatty liver, four gut microbiota and cirrhosis, eight gut microbiota and hepatocellular carcinoma, four gut microbiota and cholelithiasis, 12 gut microbiota and acute pancreatitis, eight gut microbiota and chronic pancreatitis, and 11 gut microbiota and pancreatic cancer. These findings shed light on the intricate relationship between gut microbes and the emergence of these specific gastrointestinal conditions.ConclusionsThe findings of this extensive study not only validate the potential role of specific gut microbiota in gastrointestinal diseases, but also fill a critical gap in previous research. The discovery of these specific gut microbiota is a significant step forward because they may serve as novel and promising biomarkers for both the prevention and treatment of gastrointestinal conditions.

The Causal Association between Gut Microbiota and Pancreatic Cancer: A Two-sample Mendelian Randomization Analysis in European and East Asian Populations

“…However, these findings varied from the results obtained from biobanks in the UK and Japan. [29, 30]. All this evidence suggested that the PC-related gut microbiota signatures varied across different populations.…”

Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study

“…Our study employed the MR methods to investigate a causal relationship between GM and PC, aligning with the results of previous studies. 12 , 13 , 14 , 15 , 16 They revealed various associations between different types of GM and PC due to the differences in the data sources used. Besides validating the causal relationship between GM and PC, we utilized SMR methods to integrate GM GWAS with blood cis‐eQTLs data and blood cis‐mQTLs data, respectively, aiming to identify genes in the blood tissue affected by GM.…”

“… 10 , 11 Currently, MR methods have been increasingly applied to investigate the causal relationship between GM and PC. 12 , 13 , 14 , 15 , 16 However, the genes potentially involved in interactions between GM and PC remain poorly understood. To address this, Summary data‐based Mendelian Randomization (SMR) methods have been developed.…”

Metabolic aspects of fatty pancreatic disease

“…В работе M. Signoretti и соавт. отмечается связь между активностью воспалительных процессов в ПЖ и микробным составом кишки, однако авторы делают акцент на течении хронического панкреатита, отмечая, что данные относительно связи стеатоза ПЖ и микробиома кишки освещены в литературе достаточно скудно [14].…”