Association between H19 SNP rs217727 and lung cancer risk in a Chinese population: a case control study

Guo, Genyan; Zhang, Haibo; Zhou, Baosen; Bai, Linquan; Chen, He; Zhao, Yang; Yan, Ying

doi:10.1186/s12881-018-0573-1

Cited by 29 publications

(33 citation statements)

References 41 publications

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“…Then, we excluded totally 11 articles including 7 letters, reference abstracts and reviews and 4 articles which were not focussing on cancer susceptibility. Finally, a total of 26 eligible articles (60 studies) published from 2008 to 2019 were recruited in this meta-analysis, including 19 studies on rs217727 C > T polymorphism [19][20][21][22][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39], 13 studies on rs2839698 G > A polymorphism [19][20][21]26,27,30,31,33,34,36,38,40,41], 21 studies on rs2107425 polymorphism [27,28,[41][42][43][44][45][46] and 7 studies on rs3024270 polymorphism [20,33,34,36,[38][39][40]. The detailed characteristics and genotype distrib...…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Liu

Zhao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Recently, numerous studies have been performed to detect the association between H19 polymorphisms and cancer susceptibility. However, their results were inconsistent and controversial. So, we carried out a meta-analysis aiming to define the association exactly. Eligible studies were collected using PubMed and Embase databases up to March 31, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. Sensitivity analysis and publication bias were established to evaluate the robustness of our results. Totally, 60 studies involving 20763 cases and 27403 patients were analysed in our meta-analysis. Our results indicated that H19 rs217727 C > T polymorphism was significantly associated with increased cancer risk. In subgroup analysis, similarly increased risk could be found in gastrointestinal group for rs2839698 and protective effect was observed in rs2107425 polymorphism for cancer development in Caucasian population. Trial sequential analysis strengthened findings of our meta-analysis that cumulative evidence was adequate. In summary, our meta-analysis supported that H19 polymorphisms may be associated with cancer susceptibility.

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Section: Characteristics Of Studiesmentioning

confidence: 99%

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Liu

Zhao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…The recent investigation was performed on the 555 lung cancer patients (LC) and 618 healthy individuals to evaluate the relationship between rs217727 polymorphisms with the susceptibility of LC. They noted that the homozygous genotype of rs217727 was notably correlated with an elevated LC risk …”

Section: Discussionmentioning

confidence: 99%

“…They noted that the homozygous genotype of rs217727 was notably correlated with an elevated LC risk. 25 Yang et al 12 studied the effect of four independent lncRNA-H19 SNPs (rs217727, rs2839698, rs3741216, and rs3741219) with gastric cancer risk in China population and showed that the T allele of rs217727 was associated with a higher risk of gastric cancer. Individuals with rs2839698 TT genotype showed a significant increase in gastric cancer susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

Abdollahzadeh

Ghorbian

2018

Clinical Laboratory Analysis

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Background The H19 is a maternally expressed imprinted gene transcribing a long noncoding RNA (lncRNA), which has previously been reported to be involved in tumorigenesis and cancer progression. The aim of this study was to evaluate the associations between two lncRNA‐H19 (rs3741219 T>C and rs217727 C>T) gene polymorphisms with the risk of breast cancer (BC). Methods In a case‐control investigation, we evaluated 150 BC patients and 100 cancer‐free subjects in East Azerbaijan Province of Iran. To assess two gene polymorphisms, the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method was used. Results The genotype frequencies of two lncRNA‐H19 (rs217727 C>T and rs3741219 T>C) gene polymorphisms TT + TC/CC and CC + CT/TT have not shown a statistically significant association with the risk of BC (P = 0.065; OR = 0.967; 95% CI, 0.938‐0.996) and (P = 0.510; OR = 1.583; 95% CI, 0.399‐6.726), respectively. In addition, our findings revealed a significant differences in allele frequencies in lncRNA‐H19 rs217727 C>T polymorphism between groups (P = 0.033; OR = 1.985; 95% CI, 1.048‐3.761). Conclusion Our findings suggested that rs217727 C>T polymorphism may be involved in the pathogenesis of BC, whereas rs3741219 T>C variation may not be involved in the genetic background of BC in Iranian.

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“…Other polymorphisms of H19 such as rs4930101, rs11042170, and rs27359703 significantly increased the risk of Chinese colorectal cancer patients [122]. Li et al also reported that the H19 rs217727 SNP was associated with the risk of lung cancer in a Chinese population [123]. The lncRNA H19 was overexpressed in a sample of French breast adenocarcinomas compared with healthy tissues which was also significantly associated with the presence of both estrogen and progesterone receptors [124].…”

Section: Breast Cancermentioning

confidence: 97%

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

2020

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Background: Cancer is associated with various genetic and environmental risk factors. Beside the mutations or aberrant expression of protein-coding genes, the genetic deregulation of non-coding RNAs has also an important role during tumor progression and metastasis. Long non-coding RNAs (lncRNAs) are a class of ncRNAs larger than 200 nucleotides that may function as tumor-suppressor or oncogene. Main body:There is a raising trend of cancer incidence among Iranian population during the last decades. Therefore, it is required to prepare a general population specific panel of genetic markers for the early detection of cancer in this population. The tissue-specific expression characteristics and high stability in body fluids highlight the lncRNAs as efficient diagnostic and prognostic noninvasive biomarkers in cancer. In present review we summarized all of the lncRNAs which have been reported until now in different tumors among Iranian patients. Conclusions:This review paves the way of introducing a population based noninvasive diagnostic panel of lncRNAs for the early detection of tumor cells among Iranian population.

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Association between H19 SNP rs217727 and lung cancer risk in a Chinese population: a case control study

Cited by 29 publications

References 41 publications

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Quantitative assessment of lncRNA H19 polymorphisms and cancer risk: a meta-analysis based on 48,166 subjects

Association of the study between LncRNA‐H19 gene polymorphisms with the risk of breast cancer

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

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