Association between haemorrhages and treatment with selective and non-selective serotonergic antidepressants: Possible implications of quantitative signal detection

Gahr, Maximilian; Zeiss, René; Lang, D.; Connemann, Bernhard J.; Hiemke, Christoph; Muche, Rainer; Freudenmann, Roland W.; Schönfeldt‐Lecuona, Carlos

doi:10.1016/j.psychres.2015.07.024

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…The same was found for patients treated with OAs than SSRIs (OR, 1.69; 95% CI, 1.17‐2.44) and augmented in patients receiving a combination of SSRIs and OAs (OR, 3.32; 95% CI, 1.79‐6.13). The mechanism behind the increased use of transfusions (and presumably perioperative bleedings) is most probably an SSRI‐induced inhibition of serotonin reuptake in PLTs and thereby compromised PLT aggregation and increased bleeding time …”

Section: Discussionmentioning

confidence: 99%

“…The underlying mechanism is believed to rely on SSRI‐induced inhibition on serotonin reuptake in PLTs, thereby reducing the serotonin release from PLTs in case of vascular damage (surgery). Consequently, serotonin‐induced PLT aggregation and vasoconstriction is inhibited, ultimately leading to compromised aggregation and increased bleeding time . This pharmacologic effect is supported clinically across surgical procedures .…”

mentioning

confidence: 93%

“…Bleeding and blood transfusions are of concern in total hip and knee replacement surgery, since allogenic blood transfusion has been suggested as an independent risk factor of serious adverse events such as surgical site infection, prolonged length of stay, and cardiopulmonary complications . In this context, recent data suggest that selective serotonin reuptake inhibitors (SSRIs) may be important in perioperative blood management because of their impairment of platelet (PLT) activity and detrimental effect on hemostasis …”

mentioning

confidence: 99%

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Psychopharmacologic treatment and blood transfusion in fast‐track total hip and knee arthroplasty

et al. 2017

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Section: Discussionmentioning

confidence: 99%

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confidence: 93%

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confidence: 99%

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Psychopharmacologic treatment and blood transfusion in fast‐track total hip and knee arthroplasty

et al. 2017

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“…Abnormal bleeding. All antidepressants with serotonergic action have been associated with an increased risk of bleeding [29,[48][49][50][51][52].…”

Section: Sa Alvano and Lm Ziehermentioning

confidence: 99%

“…Among the main mechanisms involved in this ADR, a reduction in the uptake of serotonin by platelets might be implicated due to the inhibition of SERT [48,52,53], which was related to a decrease in platelet activation and aggregation [54,55]. The risk of bleeding may increase with the concomitant use of drugs that interfere with hemostasis [48,49,51,55].…”

Section: Sa Alvano and Lm Ziehermentioning

confidence: 99%

An updated classification of antidepressants: A proposal to simplify treatment

Alvano

Zieher

2020

Personalized Medicine in Psychiatry

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A B S T R A C TBackground: An exhaustive review of the main worldwide psychiatry-related literature sources shows that the present antidepressants' classification does not have a logical and epistemic nomenclature oriented to allow a quick recognition of main adverse drug reactions (ADRs) and pharmacodynamic interactions. Methods: The study was performed in two phases. In the first, a new classification of antidepressants was built up based on their mechanisms of action. Furthermore, relevant ADRs and pharmacodynamic interactions were grouped according to their causal mechanisms.In the second phase a comparative, prospective, longitudinal, experimental and randomized study was performed.312 physicians who were great prescribers of antidepressants were randomly assigned to one of two groups, A and B, having 156 physicians each. Each group was assessed with a questionnaire evaluating basic knowledge of the most important ADRs and pharmacodynamic interactions. This questionnaire was provided before and after the assignment of a standard classification (group A) or the new classification (group B). In the questionnaire provided after the assignments, some questions about different acceptance variables were included. Results: After handing the classifications, significant differences were found (p = 0.0008) in the number of correct answers in the second questionnaire, in favor of group B. In addition, analysis of acceptance variables showed significant differences between both groups, in favor of the new classification. Conclusion: This study shows that the new classification of antidepressants allows, in contrast with the standard classifications, to quickly inform and enable physicians to easily relate each drug to important ADRs and pharmacodynamic interactions.

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Association of bleeding with serotonergic antidepressants in patients receiving left ventricular assist device support

et al. 2021

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Association between haemorrhages and treatment with selective and non-selective serotonergic antidepressants: Possible implications of quantitative signal detection

Cited by 19 publications

References 22 publications

Psychopharmacologic treatment and blood transfusion in fast‐track total hip and knee arthroplasty

Psychopharmacologic treatment and blood transfusion in fast‐track total hip and knee arthroplasty

An updated classification of antidepressants: A proposal to simplify treatment

Association of bleeding with serotonergic antidepressants in patients receiving left ventricular assist device support

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