Association between Helicobacter pylori infection and irritable bowel syndrome

Abstract

Background: In recent years, the incidence of IBS has gradually increased, and it is considered as one of the most common functional gastrointestinal diseases. However, the etiology of IBS is still unclear, and expectations are rising for more targeted treatments. Many clinical trials have explored the link between Helicobacter pylori ( H pylori ) and IBS, with different conclusions. Therefore, we conducted a meta-analysis to explore whether there is an association between H pylori and IBS, which is of great significance for targeted treatment of IBS. Methods: We performed a systematic review and meta-analysis of the association between H pylori and IBS. We searched PubMed, EMBASE, Medline and the Cochrane Library to collect related studies. OR was used to describe the ratio of the probability of the H pylori infection occurring in IBS patients versus the controls. Heterogeneity was assessed by subgroup and meta-regression analysis. Results: Eight studies, including 1861 patients, assessed the association between H pylori infection and IBS. The OR of H pylori in IBS patients compared to controls was 1.32 (95% CI: 0.94–1.87; P = 0.11). Subgroup analyses showed a difference between IBS patients diagnosed with Roman III criteria and those diagnosed with non-Roman III criteria. Conclusions: Our study suggests that H pylori may have a positive effect on the development of IBS. Although the differences were not statistically significant, there were significant differences among subgroups of patients. Considering the limitations and heterogeneity, high quality studies are needed to further explore the effect of H pylori on the development of IBS.

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

“…A meta‐analysis conducted up until January 2021, which included 22 studies with a total of 206,911 patients in case–control studies, indicated that individuals infected with H. pylori had a higher likelihood of developing metabolic syndrome in both case–control studies (pooled OR = 1.19, 95% CI: 1.05–1.35) and cohort studies (pooled HR = 1.31, 95% CI: 1.13–1.51) 25 . Another more recent retrospective cross‐sectional study in China reinforced these associations within the same population, utilizing five diagnostic criteria simultaneously (IDF, ATP III, JIS, CDS, and CDS DM) 26 …”

“…Numerous studies have investigated the association between H. pylori infection and insulin resistance, but the results remain conflicting 26,50,51 . A previous meta‐analysis of 22 case–control studies involving 206,911 participants, covering the period from 1991 to January 2021, quantified a combined OR of 1.54 (95% CI: 1.19–1.98) for the association between H. pylori infection and insulin resistance 25 .…”

Expression of NF-κB mRNA in Helicobacter pylori Positive Iraqi Patients with Inflammatory Bowel Diseases and Colorectal Cancer

“…Regarding IBD, there are many evidences supporting a multifactorial genesis comprising a combination of genetic predisposition, immune response, and environment, most notably the bacterial gut microbes or luminal antigens [19]. Certain studies detected H. pylori infection among IBD patients, so they suggested a possible role of H. pylori in IBD group, although other studies suggested no possible role of H. pylori in IBD indicating that the role of H. pylori in IBD is still controversial [20]. The present study disclosed presence of H. pylori in 66.7% of CRC patients and 36.7% of IBD patients compared to 33.3% in the NC group, and analysis of data reflects nonsignificant differences.…”

¿Existe relación entre <i>Helicobacter pylori</i> y el síndrome de intestino irritable?

“…Es posible que la falta de asociación entre H. pylori y SII en los estudios anteriores se deba a la gran heterogeneidad de los estudios y tamaños de muestra pequeñas 24,25 .…”