Association between Helicobacter pylori Infection and Nasal Polyps: A Systematic Review and Meta-Analysis

Abstract

Background: Helicobacter pylori (H. pylori) has definite or possible associations with multiple local and distant manifestations. H. pylori has been isolated from multiple sites throughout the body, including the nose. Clinical non-randomized studies with H. pylori report discrepant data regarding the association between H. pylori infection and nasal polyps. The aim of this first systematic review and meta-analysis was the assessment of the strength of the association between H. pylori infection and incidence of nasal polyps. Methods: We performed an electronic search in the three major medical databases, namely PubMed, EMBASE and Cochrane, to extract and analyze data as per PRISMA guidelines. Results: Out of 57 articles, 12 studies were graded as good quality for analysis. Male-to-female ratio was 2:1, and age ranged between 17–78 years. The cumulative pooled rate of H. pylori infection in the nasal polyp group was 32.3% (controls 17.8%). The comparison between the two groups revealed a more significant incidence of H. pylori infection among the nasal polyp group (OR 4.12), though with high heterogeneity I2 = 66%. Subgroup analysis demonstrated that in European studies, the prevalence of H. pylori infection among the nasal polyp group was significantly higher than in controls, yielding null heterogeneity. Subgroup analysis based on immunohistochemistry resulted in null heterogeneity with preserving a statistically significant difference in H. pylori infection prevalence between the groups. Conclusion: The present study revealed a positive association between H. pylori infection and nasal polyps.

Impact of Helicobacter pylori and metabolic syndrome-related mast cell activation on cardiovascular diseases

“…Helicobacter pylori infection, representing a high worldwide burden (1), has recently garnered growing attention for its potential role in various systemic disorders including cardiovascular diseases (CVDs) (2)(3)(4)(5)(6)(7). Although H. pylori has been primarily associated with gastric disorders, particularly peptic ulcers, gastric adenocarcinoma, and MALT (mucosa-associated lymphoid tissue) lymphoma (8,9), mounting evidence suggests that this bacterium can exert a systemic influence, affecting diverse pathophysiological processes beyond the gastrointestinal tract (2,6,7).…”

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

“…Helicobacter pylori (H. pylori) infection represents a significant global health concern [1] and has recently received increased consideration for its potential role in various systemic pathologies [2][3][4][5]. While this microorganism is predominantly related to gastrointestinal pathologies such as gastroduodenal ulcer disease, gastric cancer, or MALT (mucosaassociated lymphoid tissue) lymphoma, increasing evidence indicates that H. pylori is also linked to systemic disorders [5], including adverse pregnancy and neonatal outcomes.…”

Multidisciplinary Approach To The Problem Of Managing Children With Frequent Respiratory Infections Of The Upper Respiratory Tract: Key Results

“…По данным проспективного исследования [12], подтверждена высокая частота инфицирования H. pylori у детей с хроническим тонзиллитом по сравнению с контрольной группой (пациенты с гипертрофией небных миндалин) при идентификации данного патогена в биоптатах небных миндалин, удаленных при тонзиллэктомии. Также у пациентов с хроническим тонзиллитом выявлена значимая взаимосвязь между положительным результатом обнаружения H. pylori и косвенными признаками ларингофарингеального рефлюкса при назофиброларингоскопии (отек голосовых складок, диффузный отек гортани, гиперемия и гипертрофия задней комиссуры) [13].…”