Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis

Upala, Sikarin; Sanguankeo, Anawin; Wijarnpreecha, Karn; Jaruvongvanich, Veeravich

doi:10.1007/s00774-015-0703-1

Cited by 29 publications

(38 citation statements)

References 5 publications

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“…A systemic review conducted by Upala S et al concluded that the H. pylori infection was positively associated with MetS, higher TG, FPG, BMI, HOMA-IR, systolic blood pressure and lower HDL-C, most of which were compatible to the results in our study [35]. However, previous reports showed some inconsistencies regarding different components of MetS affected by H. pylori infection.…”

Section: Discussionsupporting

confidence: 91%

The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding

Oveidzadeh¹,

Emtiazy²,

Habibi³

et al. 2017

J Metabolic Synd

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Objectives: The global prevalence of Helicobacter pylori (H. pylori) infection remains high. Recent studies demonstrated the potential relationship among H. pylori-induced chronic inflammation, insulin resistance and metabolic disorders. The aim of this study was to investigate the association between H. pylori infection and metabolic syndrome (MetS). Methods:This cross-sectional study enrolled 4,232 health examination participants aged from 30 to 65-year-old in the northern Taiwan in 10 years. The general information and blood tests of all subjects were collected from the health examination center. H. pylori infection was diagnosed via 13 C-urea breath test. The log-transformed (log) serum high sensitivity C-reactive protein (hs-CRP) was used as the inflammatory parameter. MetS was defined according to the revised National Cholesterol Educational Program Adult Treatment Panel III (Revised NCEP ATP III) criteria. Subjects were divided into two groups based on their H. pylori infectious status. The association between H. pylori infection and metabolic parameters was assessed with multivariate logistic regression analysis. Results:A total of 4,232 subjects (2,641 males and 1,591 females, aged 47.0 years ± 8.2 years) were enrolled for the analysis. H. pylori infection presented in 44.8% of all subjects. MetS presented in 27.6% of all subjects. Participants with H. pylori infection showed higher proportion of MetS, higher body mass index(BMI) and higher serum cholesterol(T-CHO) levels with statistical significance (p<0.001). There was no significant difference in the log serum hs-CRP between subjects with and without H. pylori infection. H. pylori infection increased the risk of large waist circumference component [OR=1.26 (1.10-1.43)] and high fasting plasma glucose component [OR=1.18 (1.04-1.34)], and contributed significantly to the presence of MetS with adjusted OR 1.23 (1.03-1.46). Conclusions:Adults with H. pylori infection was associated with higher prevalence of MetS, higher BMI and higher mean serum T-CHO levels. Furthermore, H. pylori infection was identified as a risk factor for MetS.

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Section: Discussionsupporting

confidence: 91%

The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding

Oveidzadeh¹,

Emtiazy²,

Habibi³

et al. 2017

J Metabolic Synd

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“…These results showed a pathogenic linkage between HPI and diabetes [74] . There were significant differences of fasting blood glucose, high-density lipoprotein cholesterol between HPI patients and healthy controls [75] . Hsieh et al reported that long-term HPI was significantly associated with increased levels of HbA1c and decreased insulin secretion in Chinese population [76] .…”

Section: Diabetes Mellitusmentioning

confidence: 84%

“…pylori infection is reported to be associated with insulin resistance, diabetes mellitus and metabolic syndrome [74][75][76] . Compared to non-diabetics with HPI, the levels of oxidative DNA damage (8-OHdG) in type 2 diabetes mellitus could be much higher (p = 0.001).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

2017

Med One

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Helicobacter pylori (H. pylori) infection (HPI) is one of the most widespread diseases. More than half of world population is affected by HPI, especially children in developing countries. The associations between many gastrointestinal diseases and HPI have been found in clinical. Also, there are some diseases whose HPI associations are controversial and unclear. Due to its unclear disease association, H. pylori test is not included in the clinical screening. However, some pre-clinical studies showed possible associations between HPI and these diseases, involving pathological changes of different functional systems of the human body (e.g., Immune system, cerebrovascular system). Therefore, for HPI patients, more attention should be paid to the possible risks of these diseases. In this study, a systematic literature review was conducted to identify and classify H. pylori related diseases. This review identified 175 HPI related diseases belonging to 9 categories, and summarized the corresponding supporting literature reports. In addition, the functional mechanisms underlying the linkages between HPI and 28 well studied diseases were discussed, revealing possible pathogenesis for these diseases. We conclude that HPI is related to many serious diseases affecting multiple important human systems, and clinical HPI treatment and HPI test might help the detection and treatment of these diseases. Our results guarantee further study using more data to testify the possible relations between HPI and these diseases.

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“…Recently, a meta-analysis using 5 studies [15,18,20,21,44] from Asian countries demonstrated that H. pylori infection does not seem to be an important factor related to osteopenia [45]. However, some previous studies showed a relationship between H. pylori infection and osteoporosis [16,17,18,19,20,21].…”

Section: Discussionmentioning

confidence: 99%

Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

Chinda

Shimoyama²,

Takikawa³

et al. 2017

Digestion

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Background: The primary cause of osteoporosis in women is increased bone resorption and decreased bone density associated with reduced estrogen secretion. Several studies have demonstrated a relationship between Helicobacter pylori infection and osteoporosis regardless of estrogen levels. This study examined the relationship between H. pylori infection and osteopenia together with estrogen levels, calcium intake, and several lifestyle factors. Methods: This study included 473 healthy women who underwent a general health examination. Multivariate analysis was performed, with age, body mass index (BMI), smoking habit, drinking habit, exercise habit, schooling duration, estradiol levels, birth history, calcium intake, schooling duration, smoking habit, drinking habit, exercise habit, and H. pylori infection as independent variables and the presence of osteopenia as a dependent variable. Results: The adjusted OR for osteopenia with H. pylori infection was 0.95 (95% CI 0.55-1.63, p = 0.84). In contrast, osteopenia was significantly associated with age, low BMI, lesser schooling period, low estradiol levels, and low calcium intake. Conclusions:H. pylori infection was not a significant risk for osteopenia by the multivariate analysis, which included the primary confounding factors. Significant factors, such as estradiol and calcium intake, should be assessed together to study the association of H. pylori infection and osteopenia.

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Association between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis

Cited by 29 publications

References 5 publications

The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding

The Effect of Trigonella Foenum Graceum L. (Fenugreek) on Metabolic Syndrome: An Accidental Finding

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

Decrease of Estradiol and Several Lifestyle Factors, but Not <b><i>Helicobacter pylori</i></b> Infection, Are Significant Risks for Osteopenia in Japanese Females

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