Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome

Chung, Tae-Heum; Kim, Moon-Chan; Kim, Chang-Sup

doi:10.4082/kjfm.2014.35.2.81

Cited by 16 publications

(33 citation statements)

References 25 publications

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“…Using structural equation modeling, we found a direct favorable effect of chronic HBV infection on lipid profiles, but no significant effect on other metabolic derangements in both the males and females after taking into account potential confounders and interactions. Previous studies have also shown an inverse association between chronic HBV infection and triglyceride levels in different ethnic populations . Similarly, we found that chronic HBV infection was associated with a lower prevalence of hypertriglyceridemia among nondiabetic subjects.…”

Section: Discussionsupporting

confidence: 86%

Relationship between chronic hepatitis B and metabolic syndrome: A structural equation modeling approach

Huang

Liu

et al. 2015

Obesity

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Objective: Investigate the nature of the relationship between chronic hepatitis B virus (HBV) infection and metabolic syndrome among nondiabetic adults. Methods: This was a cross-sectional analysis of 17,030 nondiabetic adults (7437 males and 9593 females; mean age, 36.0 6 3.9 years) in northern Taiwan from 2008 to 2009. The associations of hepatitis B surface antigen (HBsAg) seropositivity with metabolic syndrome and cardio-metabolic parameters were assessed. A structural equation model was constructed to elucidate the pathways between chronic HBV infection and individual cardiometabolic risk factors. Results: A total of 2982 (17.5%) participants were HBsAg-seropositive. Of the seropositive and seronegative subjects, 15.5 and 16.9% had metabolic syndrome, respectively. The HBsAg-seropositive subjects had a lower odds of having metabolic syndrome compared with the seronegative subjects irrespective of gender and age (OR: 0.76, 95% CI: 0.68-0.85). The inverse associations remained significant after adjusting for body mass index and serum alanine aminotransferase levels. HBsAg seropositivity was inversely associated with hypertriglyceridemia (OR: 0.59, 95% CI: 0.52-0.66), and low serum levels of high-density lipoprotein cholesterol (OR: 0.86, 95% CI: 0.79-0.93) after adjustments. The structural equation model revealed chronic HBV infection had a significant negative effect on dyslipidemia both in males (B 5 20.054) and females (B 5 20.064). Conclusions: The inverse relationship between chronic HBV infection and metabolic syndrome may be attributable to the net beneficial effects on lipid profiles.

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Section: Discussionsupporting

confidence: 86%

Relationship between chronic hepatitis B and metabolic syndrome: A structural equation modeling approach

Huang

Liu

et al. 2015

Obesity

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“…Chronic HBV infection is associated with lower prevalence of hypertriglyceridemia in men and women (Jan et al 2006;Chen et al 2010;Wong et al 2012;Chung et al 2014;Huang et al 2016). In this study, however, OBI was detected at higher frequency in HLP patients than in replacement blood donor population controls (9.5% vs. 2.4%, P < 0.001), which suggested a positive association between OBI and HLP.…”

Section: Discussioncontrasting

confidence: 68%

“…Previous studies showed that chronic hepatitis B virus (HBV) infection was associated with lower prevalence of hypertriglyceridemia (Jan et al 2006;Chen et al 2010;Wong et al 2012;Chung et al 2014;Huang et al 2016) or hypercholesterolemia (Chen et al 2010;Liu et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Yang

Li²,

Li³

et al. 2017

Tohoku J. Exp. Med.

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Chronic hepatitis B virus (HBV) infection is associated with lower prevalence of hyperlipidemia (HLP).However, occult HBV infection (OBI) in HLP patients has not yet been explored. OBI is defined as the presence of detectable HBV DNA in serum or liver tissue but undetectable HBV surface antigen in serum. In this study, 1,036 HLP patients and 1,134 replacement blood donor controls were recruited. Among them, 252 HLP patients and 255 blood donors with antibody to HBV core positive were selected and analyzed. HBV DNA was confirmed by nucleic acid testing assays, and nucleotide mutations were analyzed. OBI was detected in 9.5% (24/252) of HLP patients and 2.4% (6/255) of blood donors, respectively (P < 0.001). In HLP population, 41.7% of OBI and 13.6% of non-OBI carriers were associated with daily alcohol consuming > 30 g/day (P < 0.01), while in control population those rates were not statistically different between OBI and non-OBI carriers (P > 0.05). Viral load of OBI in HLP patients was higher than that of OBI in blood donors (P < 0.05), which was a positive correlation between total cholesterol and HBV viral load levels (r = 0.474 P = 0.019). HBV vaccination rate was found significantly lower in OBI HLP patients than that in non-OBI HLP patients (P < 0.01). Importantly, mutations were found in basic core promoter region of HBV among OBI HLP patients. In conclusion, the frequency of OBI is significantly higher in HLP patients, especially those patients with heavy daily alcohol consumption.

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“…Moreover, no possible gender effect of CHB on MS was examined, despite adjustment for age and gender. Consistent with us, Chung et al explored how gender differences affected the association between the MS and CHB infection and showed that HB infection was negatively associated with MS in men [Chung et al, ]. Zhou et al in a 20‐year follow‐up retrospective cohort study in Shanghai, showed a positive association between HB infection and MS [Zhou et al, ].…”

Section: Discussionmentioning

confidence: 74%

Chronic hepatitis B infection is not associated with increased risk of vascular mortality while having an association with metabolic syndrome

Katoonizadeh

Ghoroghi

Sharafkhah

et al. 2016

Journal of Medical Virology

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This study aimed to assess the association of chronic hepatitis B (CHB) with vascular mortality and metabolic syndrome (MS) using data from a large population-based cohort study in Iran. A total of 12,781 participants (2249 treatment-naïve CHB and 10,532 without CHB) were studied. Logistic regression model was used to assess the association between MS and CHB with adjustment for age, ALT, PLT, alcohol intake, smoking, exercise, and socioeconomic status. MS was defined according to the ATPIII guidelines. Cox proportional hazards model was used to assess the hazard ratios for overall and vascular related mortality. There was a significant association between CHB infection and overall mortality (hazard ratio (95%CI) of 1.44 (1.16-1.79), P < 0.001) after adjusting for other confounders. However, we found no association between CHB infection and mortality from vascular events (hazard ratio (95%CI) of 1.31 (0.93-1.84), P = 0.124) even after subgroup analysis by ALT. Furthermore, increased risk of overall mortality in CHB infected individuals was not related to MS and vice versa (P for interaction = 0.06). We noted a significant direct association between CHB infection and MS in women (OR (95%CI); 1.23 (1.07-1.42), P < 0.004). However, CHB was inversely associated with MS in men (OR (95%CI), 0.85 (0.79-0.99). This gender dependent association was related to high BP levels in women. In this study no association between CHB infection and mortality from vascular events was found. Further longitudinal studies should be done to investigate the exact impact of HBV infection on metabolic parameters and vascular pathology.

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Association between Hepatitis B Surface Antigen Seropositivity and Metabolic Syndrome

Cited by 16 publications

References 25 publications

Relationship between chronic hepatitis B and metabolic syndrome: A structural equation modeling approach

Relationship between chronic hepatitis B and metabolic syndrome: A structural equation modeling approach

Occult Hepatitis B Virus Infection in Hyperlipidemia Patients

Chronic hepatitis B infection is not associated with increased risk of vascular mortality while having an association with metabolic syndrome

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