Association between hepatitis B virus infection and risk of osteoporosis: a systematic review and meta-analysis

Xie, Xingwen; Huang, Rui; Li, Xiuxia; Li, Ning; Zhang, Haijun; Xu, Shihong; Li, Dingpeng; Xi, Shanshan; Yang, Kehu

doi:10.1097/md.0000000000019719

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Viruses that have been shown to be associated with OP include human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [36][37][38][39][40]. In the present study, we demonstrated that HPV infection led to a decrease in BMD.…”

Section: Discussion：mentioning

confidence: 52%

“…The obtained samples were tested with the Roche linear array HPV genotyping test to determine the presence of HPV infection and the type of HPV in cases of infection. This method can detect 37 HPV types : 6,11,16,18,26,31,33,35,39,40,42,45,51,52,53,54,55,56,58,59,61,62,64,66,67,68,69,70,71,72,73,81,82,83,84,89,and IS39. We included subjects who were not infected with HPV in group A and those who were infected (all types) into group B. Subjects with missing data were excluded.…”

Section: Hpv Infectionmentioning

confidence: 99%

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A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

Jiao

Chen

2022

Preprint

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Background: Globally, both human papillomavirus (HPV) infection and osteoporosis (OP) are more prevalent in women than in men. It remains unclear whether HPV has an impact on bone health.<br />Methods: This case?control study was based on data from the National Health and Nutrition Examination Survey (NHANES). Comparable datasets were created via the nearest neighbor propensity score matching (PSM) method (1:2). The Welch two-sample t test was used to analyze the association between HPV infection and bone mineral density (BMD). Restricted cubic spline (RCS) and Kendall's tau-b tests were used to explore the effect of HPV infection type on BMD.<br />Results: BMDs in the legs and lumbar spine were lower in subjects infected with HPV than in uninfected subjects. RCS analysis showed that the larger the number of cooccurring HPV types in a woman, the lower the BMD was. In addition, four HPV types were negatively associated with leg BMD, and 14 HPV types were negatively associated with lumbar spine BMD. HPV types 53, 59, and 89 had effects on both leg and lumbar spine BMDs.<br />Conclusions: HPV infection was associated with a decrease in BMD. Appropriately designed trials can help determine whether interventions to prevent HPV infection will have a protective effect on BMD.<br />Funding: This research was not supported by any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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Section: Discussion：mentioning

confidence: 52%

Section: Hpv Infectionmentioning

confidence: 99%

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

Jiao

Chen

2022

Preprint

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“…4,5 According to a recent meta-analysis, patients with CHB were at greater risk of developing osteoporosis than those without hepatitis B virus (HBV). 6 Oral nucleos(t)ide analogues (NUCs) are effective and welltolerated treatment options for patients with CHB and offer potent inhibition of HBV replication. [7][8][9] Tenofovir disoproxil fumarate (TDF, 300 mg daily), a prodrug of the nucleotide analogue tenofovir, has potent clinical efficacy and is generally well-tolerated; however, it may lead to renal injuries 10 and the decreased bone mineral density (BMD), especially in the elderly patients.…”

Section: Introductionmentioning

confidence: 99%

“…Liver cirrhosis has been shown to cause osteopenia/osteoporosis likely due to an imbalance in bone remodelling that leads to increased resorption and decreased bone formation 4,5 . According to a recent meta‐analysis, patients with CHB were at greater risk of developing osteoporosis than those without hepatitis B virus (HBV) 6 …”

Section: Introductionmentioning

confidence: 99%

Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study

Ogawa,

Jun,

Toyoda

et al. 2023

Aliment Pharmacol Ther

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SummaryBackgroundData on patients switched to tenofovir alafenamide (TAF) from nucleos(t)ide analogues (NUCs) other than tenofovir disoproxil fumarate are limited.AimsTo assess the treatment and renal/bone safety outcomes following the switch to TAF.MethodsWe prospectively enrolled adult patients with chronic hepatitis B (CHB) who switched from any NUC to TAF at 14 centres in Japan, Korea, Taiwan and the U.S. Study outcomes were viral suppression (VR; HBV DNA < 20 IU/mL), biochemical response (BR; alanine aminotransferase normalisation), and changes in estimated glomerular filtration rate (eGFR) and T‐scores (L‐spine) by bone absorptiometry by 24 months after switch to TAF.ResultsWe enrolled 270 eligible patients. Mean age was 58.1; 58.2% were male; 12.2% had cirrhosis and 73.3% previously received entecavir monotherapy. VR rate increased significantly from 95.2% to 98.8% by 24 months after the switch to TAF (p = 0.014). Between the switch and 24 months later, the mean spine T‐score improved significantly from −1.43 ± 1.36 to −1.17 ± 1.38 (p < 0.0001), while there was no significant change in mean eGFR (88.4 ± 16.9–89.5 ± 16.3 mL/min/1.73 m2, p = 0.13). On multivariable analysis adjusted for age, sex, baseline spine T‐score and prior TDF or adefovir dipivoxil use, male sex was significantly associated with lower risk of worsening spine T‐score (odds ratio: 0.29, p = 0.020), while age was significantly associated with a higher risk of worsening chronic kidney disease stage (OR: 1.07, p = 0.019).ConclusionsAt 24 months after the switch to TAF, VR rates and spine bone density improved significantly while renal function remained stable.

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“…Invading pathogens such as bacteria, viruses, and parasites are capable of colonizing several tissues within the human body, namely the bone, eliciting an immune response in the majority of immune competent individuals. Indeed, there is some evidence that viruses such as hepatitis B and C viruses and human immunodeficiency virus disrupt bone metabolism causing bone loss [ 1 , 2 , 3 , 4 , 5 , 6 ]. On the other hand, bacteria such as Borrelia burgdorferi , Mycobacterium tuberculosis, and Staphylococcus aureus are causative agents of osteomyelitis and subsequently lead to bone destruction [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Crossroads between Infection and Bone Loss

Oliveira

Gomes

2020

Microorganisms

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Bone homeostasis, based on a tight balance between bone formation and bone degradation, is affected by infection. On one hand, some invading pathogens are capable of directly colonizing the bone, leading to its destruction. On the other hand, immune mediators produced in response to infection may dysregulate the deposition of mineral matrix by osteoblasts and/or the resorption of bone by osteoclasts. Therefore, bone loss pathologies may develop in response to infection, and their detection and treatment are challenging. Possible biomarkers of impaired bone metabolism during chronic infection need to be identified to improve the diagnosis and management of infection-associated osteopenia. Further understanding of the impact of infections on bone metabolism is imperative for the early detection, prevention, and/or reversion of bone loss. Here, we review the mechanisms responsible for bone loss as a direct and/or indirect consequence of infection.

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Association between hepatitis B virus infection and risk of osteoporosis: a systematic review and meta-analysis

Cited by 7 publications

References 27 publications

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study

The Crossroads between Infection and Bone Loss

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