Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects

Cunha, Roberto S.; Pannier, Bruno; Bénétos, Athanase; Jp, Siché; London, Gérard M.; Mallion, Jean-Michel; Safar, Michel E.

doi:10.1097/00004872-199715120-00009

Cited by 223 publications

(169 citation statements)

References 28 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…5,[36][37][38] The effect of heart rate on arterial stiffness is somewhat a controversial issue. In a recent observational study, Sa Cunha et al 23 showed that high heart rate was strongly associated with elevated PWV even after adjustment for age and BP. The increase in heart rate by isoproterenol and pacing was associated with an increase in PWV.…”

Section: Discussionmentioning

confidence: 98%

“…In some studies, PWV was only correlated with SBP, 20,21 but in others with both SBP and DBP. 22 Sa Cunha et al 23 suggested gender difference; SBP showed correlation with PWV in both genders, whereas DBP was correlated with PWV only in women. In contrast to the previous studies, Nurnberger et al 18 reported that DBP was an only important haemodynamic determinant of PWV in young healthy males.…”

Section: Discussionmentioning

confidence: 99%

“…Although BP is one of the strongest factors influencing PWV, varying correlation coefficients have been reported between the various PWV (aorta-leg-arm) and BP (systolic, diastolic, mean, pulse) using non-invasive methods. 5,[18][19][20][21][22][23][24] This variation may be attributable, at least in part, to the inherent variability of both PWV and BP within and across individual subjects and also to the method of BP 25 and PWV measurements.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

et al. 2006

View full text Add to dashboard Cite

Blood pressure (BP) is one of the most important contributing factors to pulse wave velocity (PWV), a classic measure of arterial stiffness. Although there have been many non-invasive studies to show the relation between arterial stiffness and BP, the results are controversial. The aim of this study is to evaluate the role of BP as an influencing factor on PWV using invasive method. We observed 174 normotensive and untreated hypertensive subjects using coronary angiography. Arterial stiffness was assessed through aorto-femoral PWV by foot-to-foot velocity method using fluid-filled system. And BP was measured by pressure wave at the right common femoral artery. From univariate analysis, age, diabetes mellitus (DM), hypertension, waist, waist-to-hip ratio, total cholesterol-tohigh-density lipoprotein cholesterol ratio, systolic BP (SBP), pulse pressure (PP) and mean arterial pressure (MAP) showed significant association with PWV. To avoid multiple colinearity among SBP, PP and MAP, we performed multiple regression analysis predicting PWV thrice. Age, DM and each BP were significantly and consistently correlated to PWV. In the first and third modules, compared to age, SBP and MAP were less strong predictors, respectively. However, PP was the stronger predictor than age and DM in the second module. Lastly, we simultaneously forced MAP and PP with other variables in the fourth multivariate analysis. Age, DM and PP remained significantly correlated with PWV, but the significance of MAP was lost. This is the first invasive study to suggest that PP has the strongest correlation with PWV among a variety of BP parameters.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

et al. 2006

View full text Add to dashboard Cite

show abstract

“…10 The relationship between heart rate and blood pressure has been established in large cohorts of unselected subjects. 9 Sa Cunha et al 11 have shown that pulse wave velocity and casual heart rate at rest were positively correlated in normotensive and hypertensive patients. The same authors have also shown that ambulatory heart rate is related to pulsatile changes in the diameter of the carotid artery.…”

Section: Introductionmentioning

confidence: 98%

Association between 24-hour ambulatory heart rate and arterial stiffness

Albaladéjo

Asmar

et al. 2000

J Hum Hypertens

View full text Add to dashboard Cite

Clinical and experimental studies point to a positive association between carotid-femoral pulse wave velocity (PWVcf) and casual heart rate. However, an association with 24-h ambulatory heart rate has never been investigated. Twenty-four hour ambulatory heart rate and PWVcf (automatic computerised technique) were simultaneously measured in 213 subjects with untreated mild-to-moderate essential hypertension. It was found that mean ambulatory heart rate was higher in women than in men but the difference reached statistical significance only in those below 50 years of age during night-time measurements. As well as age and blood

show abstract

“…22,25 Others found that PWV was correlated to both SBP and DBP 18 or was correlated to SBP in both men and women, but was correlated to DBP only in women. 26 The controversial results reported in the literature may be attributed to the large variability in the population studied, such as the broad age range, gender distribution and the presence of different diseases or drug regimens. Additionally, age-related changes in the vasculature including a widening of pulse pressure, 27 changes in heart rate, blood pressure and vascular resistance 28 may further complicate the evaluation of stiffness determinants.…”

Section: Introductionmentioning

confidence: 99%

Diastolic blood pressure is an important determinant of augmentation index and pulse wave velocity in young, healthy males

Nürnberger¹,

Dammer²,

Saez

et al. 2003

J Hum Hypertens

118

View full text Add to dashboard Cite

Pulse wave velocity (PWV) and augmentation index are widely used measures of arterial stiffness. The purpose of this study was to evaluate the role of blood pressure as a determinant of both indices independent of potentially confounding factors including gender, age and cardiovascular disorders. A total of 77 young, healthy subjects were investigated under resting conditions. Augmentation index was derived by pulse wave analysis using carotid applanation tonometry. PWV was determined from pressure tracing over the carotid and femoral artery. The relations between stiffness markers and haemodynamic parameters were analysed by simple (r) and multiple (b) regression analysis. Using simple regression analysis, augmentation index was correlated to age (r ¼ 0.292, P ¼ 0.0105), diastolic blood pressure (DBP, r ¼ 0.483, Po0.0001), mean arterial blood pressure (MAP, r ¼ 0.381, P ¼ 0.0007), pulse pressure (r ¼ À0.414, P ¼ 0.0002) and total peripheral resistance (r ¼ 0.266, P ¼ 0.0204). After multiple regression analysis, augmentation index remained significantly correlated only to DBP (b ¼ 0.347, P ¼ 0.0051). Using simple regression analysis, PWV was correlated to age (r ¼ 0.304, P ¼ 0.0067), systolic blood pressure (r ¼ 0.280, P ¼ 0.0129). DBP (r ¼ 0.455, Po0.0001), MAP (r ¼ 0.446, Po0.0001) and heart rate (r ¼ 0.348, P ¼ 0.0018). After multiple regression analysis, PWV remained correlated only to age (b ¼ 0.218, P ¼ 0.0422) and DBP (b ¼ 0.4105, P ¼ 0.0316). In summary, DBP is an important determinant of augmentation index and PWV in young, healthy males. Further studies are needed to characterize the impact of blood pressure on arterial stiffness in other populations including females and older subjects.

show abstract

Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects

Cited by 223 publications

References 28 publications

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

Relationship between blood pressure parameters and pulse wave velocity in normotensive and hypertensive subjects: invasive study

Association between 24-hour ambulatory heart rate and arterial stiffness

Diastolic blood pressure is an important determinant of augmentation index and pulse wave velocity in young, healthy males

Contact Info

Product

Resources

About