Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

Abstract

Background: Obesity and metabolic syndrome are considered the risk factors of colorectal adenoma (CRA) and colorectal cancer (CRC). Chemerin is a novel adipocytokine associated with the development of gastric cancer, esophageal cancer, hepatocellular carcinoma, and CRC. However, the relationship between chemerin levels and CRA remains unclear. Objective: This study is aimed at investigating the association between serum chemerin levels and the development of CRA. Methods: We conducted a total colonoscopy-based cross-sectional case-control study of 80 male patients with CRA and 80 male age-matched control individuals without CRA, according to their endoscopic findings. Serum chemerin concentrations were measured using a sandwich enzyme-linked immunosorbent assay kit, and the OR of CRA was calculated via logistic regression analysis. Results: The mean serum chemerin level of the CRA group was significantly higher than that of the control group (7.9 ± 0.41 vs. 5.16 ± 0.34 ng/mL, p < 0.001). Serum chemerin level was positively correlated to the development of CRA (r = 0.34). Multivariate logistic regression analysis revealed that a high chemerin level was independently associated with the development of CRA (OR 2.82, 95% CI 1.39-5.72). Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.

Characteristics of the gut microbiome profile in obese patients with colorectal cancer

“…Aging and reduced food intake due to CRC development may have altered the weight of patients with CRC, particularly in the advanced stage. Nevertheless, glucose intolerance and insulin resistance were observed in patients with CRC, which is consistent with previous reports [4][5][6][7][8][9][10][11][12] that metabolic abnormalities associated with Figure 5 Comparison of the genera between obese and nonobese patients with colorectal cancer (CRC). In the obese patients with CRC, the genus Enterococcus (P = 0.04) was significantly lower, and the genera Polaribacter (P = 0.03) and Capnocytophaga (P = 0.03) were significantly higher than in the nonobese patients with CRC.…”

“…3 The underlying mechanisms linking obesity to CRC remain a matter of debate; however, metabolic syndrome, insulin resistance, and alterations in adipocytokine concentrations appear to be of great importance. 4 The authors of this study previously demonstrated that visceral fat obesity and metabolic syndrome, insulin resistance following hyperinsulinemia, 5 impaired secretion of adipocytokine [6][7][8] or incretin, 9,10 and systemic low chronic inflammation 11,12 contribute to the development of CRC or colorectal adenoma, which is a well-known precancerous lesion of CRC.…”

Serum Chemerin Does Not Differentiate Colorectal Liver Metastases from Hepatocellular Carcinoma

“…Elevated circulating chemerin in CRC patients was described in recent studies [7,9]. In patients with adenomas serum chemerin was nearly 50% higher than in healthy controls [14]. Chemerin concentration of CRC patients was about 15% increased in one CRC cohort whereas the second analysis reported a more than four-fold induction compared to healthy controls [7,9].…”

“…In colon cancer patients, chemerin was increased though it was not associated with TNM classification [9]. Sytemic chemerin was further positively related to the number of adenomas in patients with colorectal adenomas [14].…”

“…Of note, circulating chemerin was positively associated with all of the components of the metabolic syndrome [10,24,25]. Therefore, chemerin´s association with CRC may in part stem from the relationship between CRC and features of the metabolic syndrome [7,8,10,14,24,25]. Metabolic diseases also contribute to HCC development [22].…”