Association between high risk human papillomavirus infection and co-infection with Candida spp. and Trichomonas vaginalis in women with cervical premalignant and malignant lesions

Ghosh, Ishita; Muwonge, Richard; Mittal, Srabani; Banerjee, Dipanwita; Kundu, Prabir Kumar; Mandal, Ranajit; Biswas, Jaydip; Basu, Partha

doi:10.1016/j.jcv.2016.12.007

Cited by 57 publications

(75 citation statements)

References 20 publications

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“…Gweneth's study found that trichomonas vaginitis was associated with hr-HPV infection (speci cally type 16) signi cantly, but no correlation between trichomonas and cervical lesions [10] . Ishita Ghosh's study found that the higher risk of cervical cancer observed in the female coinfected with HPV and TV was without any enhanced risk of CIN [5] . But both of them were small-scale studies.…”

Section: Discussionmentioning

confidence: 98%

“…Studies found that the outcome of HPV infection was closely related to the local micro-environmental of the cervix [27] . A lot of research has discovered that TV led to an imbalance of the vaginal ora, which inhibited or reduced the lactobacillus substantially [5] , and caused severe in ammation. Evidence were found that the continuous activation of in ammatory transcription factors can lead to cervical tissue damage, and thus improved the susceptibility and carcinogenic ability of HPVl6 [10,38] .…”

Section: Discussionmentioning

confidence: 99%

“…Candida spp, Gardnerella and TV are the most common vaginal infections. As a part of the human commensal ora, Candida spp always causes systemic and super cial infections [5] . Gardnerella vaginalis is considered as playing a vital role in the pathogenesis of bacterial vaginitis (BV) [6] , and BV shows a correlation with severity of cervical neoplasia in HPV-positive female [7] .…”

Section: Introductionmentioning

confidence: 99%

“…As a sexually transmitted infectious agent, TV is found to cause local in ammation, and it affects the clearance of hr-HPV and contributes to cervical lesion detection in several research, but it is controversial [8] . Some studies have demonstrated a correlation between vaginal infection and the carcinogenicity of hr-HPV, but most of them are small-scale researches, and their conclusions are inconsistent [5,[9][10][11][12][13][14][15][16] . This research is with the most massive scale and the most comprehensive investigation about the correlation between cervical hr-HPV infection, CIN/ICC, and the vaginal microbiome.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Yang

Jiang

et al. 2020

Preprint

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Background: Evidence suggested that vaginal microbiome played a functional role in the progression of cervical lesions in female infected by HPV. This study aimed at evaluating the influence of common vaginal infection on the carcinogenicity of high risk HPV (hr-HPV). Methods: From January 15, 2017 to December 31, 2017, 310,545 female aged at least 30 years old had been recruited for cervical cancer screening from 9 clinical research centers in Central China. All the recruited participants received hr-HPV genotyping for cervical cancer screening and vaginal microenvironment test by a high vaginal swab. Colposcopy-directed biopsy was recommended for female who were infected with HPV 16 and HPV 18, and other positive hr-HPV types through test had undertaken triage using liquid-based cytology, cases with the results ≥ ASCUS among them were referred to colposcopy directly, and cervical tissues were taken for pathology examination to make clear the presence or absence of other cervical lesions.Results: Among 310,545 female, 6,067 (1.95%) were tested with positive HPV 16 and HPV 18, 18,297 (5.89%) were tested with other positive hr-HPV genotypes, cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3 and invasive cervical cancer (ICC) were detected in 861 cases, 377 cases, 423 cases, and 77 cases, respectively. Candida albicans and Gardnerella were not associated with the detection of cervical lesions. Positive trichomonas vaginitis (TV) was correlated with hr-HPV infection (p<0.0001). Co-infection with TV increased the risk of CIN 1 among female infected with hr-HPV (OR 1.18, 95% CI: 1.42-2.31). Co-infection with TV increased the risk of CIN 2-3 among female infected with HPV 16 (OR 1.71, 95% CI: 1.16-2.53).Conclusions: Co-infection of TV and HPV 16 is a significant factor for the detection of cervical lesions.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Yang

Jiang

et al. 2020

Preprint

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“…Furthermore, extensive studies have demonstrated that inflammation of cervical mucosa predisposes the epithelium to carcinogenesis. They mainly focused on the immune inhibited, co-infection, persistent infection and tumorigenesis [45][46][47][48][49][50][51][52]. However, the fundamental mechanisms of inflammation promoting the cervical carcinogenesis are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Severe Inflammation Indicates High Risk of HSIL: from a Cross-Sectional Study

Lin¹,

Long²,

Chen³

et al. 2019

Preprint

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Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytology abnormality including Cervical Intraepithelial Neoplasia (CIN) remains uncertain. The aim of this study was to investigate the correlation between them with ThinPrep cytological test (TCT) as a screening tool for cervical cancer and CIN, which can identify abnormal morphology of cervical mucosa epithelium and inflammation degrees. A retrospective analysis of clinical data from 48101 women undergoing TCT in the affiliated hospitals of Sun Yat-Sen University (SYSU) revealed that among the 8.87% (4102 cases) total positive rate of ASC, LSIL and HSIL, 67.7% (2777/4102) of TCT positive samples had inflammatory infection. The rate of severe inflammation was significantly higher in cytological abnormality group than the control group (15.1% vs. 2%, P=0.000). Our results showed that severe inflammation significantly increased incidence of cytological abnormality by 12.59 times and elevated the risk of HSIL by 756.47 times. In conclusion, severe inflammation increased the risk of cytological abnormality, and should be viewed as an important risk of HISL. These results of our study remind clinicians to be more watchful for women with severe cervical inflammation in TCT reports for earlier prevention of the HSIL.

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Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

Hamar

Teutsch

Hoffmann

et al. 2023

Intl J Gynecology & Obste

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BackgroundTrichomonas vaginalis infection is the most prevalent non‐viral sexually transmitted infection (STI) in women and has been suggested as a risk factor for developing cervical cancer.ObjectiveWe aimed to investigate the associations between T. vaginalis infection and cervical carcinogenesis.Search StrategyA comprehensive systematic search was conducted in five databases on 21 October 2021.Selection CriteriaStudies assessing the relationship between T. vaginalis infection, HPV co‐infections, cervical dysplasia, and cervical cancer were found eligible.Data Collection and AnalysisSummary estimates for pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with a random‐effects model. Statistical heterogeneity was measured with I2 and Cochran's Q tests.Main ResultsThe 29 articles included 473 740 women, of whom 8518 were T. vaginalis‐positive. Our results showed that T. vaginalis‐infected women had 1.79 times higher odds of being diagnosed with HPV co‐infection (95% CI 1.27–2.53; I2 95%). We also found that T. vaginalis infection was associated with high‐grade squamous intraepithelial lesion diagnosis (OR 2.34, 95% CI 1.10–4.95; I2 75%) and cervical cancer (OR 5.23, 95% CI 3.03–9.04; I2 3%).ConclusionsOur results showed an association between T. vaginalis and cervical carcinogenesis in sexually active women.

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Association between high risk human papillomavirus infection and co-infection with Candida spp. and Trichomonas vaginalis in women with cervical premalignant and malignant lesions

Cited by 57 publications

References 20 publications

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study.

Severe Inflammation Indicates High Risk of HSIL: from a Cross-Sectional Study

Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients

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