Association Between HIV-1 Infection, the Etiology of Genital Ulcer Disease, and Response to Syndromic Management

Abstract

Response to syndromic management of GUD was acceptable and not associated with HIV-1 coinfection.

Molecular Diagnosis of Lymphogranuloma Venereum in Patients with Genital Ulcer Disease

“…The lack of sensitive and specific diagnostic tests is likely responsible for the wide variation in prevalence of LGV in patients with genital ulcer disease (GUD) reported from Africa (2,5,6). Biovar identification of C. trachomatis in specimens from genital ulcers is important because non-LGV ulcers can be contaminated with the trachoma biovar from concurrent urethritis or cervicitis (13).…”

“…The study cohort was the same as that in the treatment efficacy study (13) Epidemiological and clinical characteristics of patients with LGV were compared with those of patients with genital herpes, chancroid, syphilis, and/or granuloma inguinale (Table 1). All infections except granuloma inguinale were diagnosed by PCR (13).…”

“…All infections except granuloma inguinale were diagnosed by PCR (13). The study was approved by the Ethics Committee of the Nelson R. Mandela School of Medicine.…”

“…Specimen collection and preparation have been described previously (13). A blood and tissue mini kit (QIAGEN, Frankfurt, Germany) was used to extract DNA.…”

Etiology of Genital Ulcerative Disease in Conjunction with HIV Infection among Patients Attending the STD Clinic at a Tertiary Care Hospital

“…A change in the prevalence patterns of the different causative agents of GUD in relation to HIV-1 infection. Some observations also indicate a more severe and prolonged clinical presentation as well as a decreased response to treatment in HIV-1-infected people (Moodley et al, 2003). There are not many studies from the developing countries, like India and no study in the state of Rajasthan to corroborate such findings, largely due to a lack of reliable laboratory data to back such studies.…”