Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV‐1‐infected South African women

Azzoni, Livio; Crowther, Nigel J.; Firnhaber, Cynthia; Foulkes, Andrea S.; Yin, Xiangfan; Glencross, Deborah K.; Gross, Robert; Kaplan, M.; Papasavvas, Emmanouil; Schulze, Doreen; Stevens, Wendy; Merwe, Tessa van der; Waisberg, Rita; Sanne, Ian; Montaner, Luis J.

doi:10.1186/1758-2652-13-33

Cited by 13 publications

(12 citation statements)

References 47 publications

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“…6 Our observations do not support this association, but the two cohorts are not similar, as our patients were on stable cART for more than 6 months. Leptin may have important immune functions and in HIVinfected patients may be positively correlated to CD4+ T lymphocytes count.…”

Section: Discussioncontrasting

confidence: 63%

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Leptin expression in HIV-infected patients during antiretroviral therapy

Tilişcan¹,

Aramă²,

Mihăilescu³

et al. 2015

GERMS

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Background Leptin is an adipokine with complex metabolic, neuroendocrine and immune functions. Our objective was to evaluate leptin serum levels in a cohort of Romanian HIV-infected patients undergoing antiretroviral therapy in relation to their immune-virological status, lipid and glucose metabolic abnormalities and the presence of metabolic syndrome (MS).Methods We enrolled consecutive non-diabetic HIV-infected patients aged 18 and over on stable cART for at least 6 months. Blood samples were tested for: leptin, CD4 T cells count, HIV viral load and lipid panel.

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Section: Discussioncontrasting

confidence: 63%

“…5,6 The serum leptin level was lower in HIV patients with a lower CD4 count. 5 Leptin levels may also be inversely correlated to HIV replication, independent of the amount of adipose tissue or disease progression.…”

mentioning

confidence: 98%

Leptin expression in HIV-infected patients during antiretroviral therapy

Tilişcan¹,

Aramă²,

Mihăilescu³

et al. 2015

GERMS

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“…Interestingly, GBV-C coinfection appeared to restore leptin levels in HIV-1-infected patients (Figure 1). A negative correlation between HIV-1 load and leptin concentration has been previously reported [26], suggesting that this cytokine may affect HIV-1 replication. No correlation was found in this study between HIV-1 load and leptin levels, neither in HIV-1-infected patients, nor in GBV-C co-infected patients (data not shown).…”

Section: Discussionmentioning

confidence: 94%

HIV-1 and GBV-C co-infection in Venezuela

Rodríguez

Garzaro

Loureiro

et al. 2014

J Infect Dev Ctries

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Introduction: Co-infection with GB virus C (GBV-C) in patients infected with human immunodeficiency virus 1 (HIV-1) has been associated with prolonged survival. The aim of this study was to evaluate the prevalence of GBV-C infection among HIV-1-infected patients in Venezuela, and to determine the effects of the co-infection on the levels of relevant cytokines. Methodology: Plasma samples were collected from 270 HIV-1-seronegative and 255 HIV-1-seropositive individuals. GBV-C infection was determined by RT-PCR of the NS5 region and genotyped by sequence analysis of the 5´UTR region. HIV-1 strains were characterized by sequence analysis of pol, vif, env, and nef genes. Selected cytokines were evaluated by ELISA. Results: Ninety-seven of 525 (18.5%) plasma samples tested positive for GBV-C RNA. A significantly higher prevalence of GBV-C was found among HIV-1 patients compared to HIV-1-seronegative individuals (67/255, 26% versus 30/270, 11%; p < 0.001). Statistical difference was observed in the viral load between HIV-1+GBV-C+ and HIV-1+GBV-C-(p = 0.014), although no differences in CD4 + cell counts were found between both groups. TNFα concentration was higher in HIV-1

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“…Azzoni et al in 2010 observed that serum leptin levels are inversely associated with HIV replication, independent of disease progression. In the same study, the authors reported a weak association between leptin levels and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [39]. Mynarcik et al (2002) found that levels of leptin did not correlate with insulin sensitivity, in HIV-infected subjects with body fat redistribution [37].…”

Section: Resultsmentioning

confidence: 99%

Insulin resistance and adipokines serum levels in a caucasian cohort of hiv-positive patients undergoing antiretroviral therapy: a cross sectional study

et al. 2013

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BackgroundInsulin resistance is frequent in human immunodeficiency virus (HIV) infection and may be related to antiretroviral therapy. Cytokines secreted by adipose tissue (adipokines) are linked to insulin sensitivity. The present study is aimed to assess the prevalence of insulin resistance (IR) and its association with several adipokines, in a non-diabetic Romanian cohort of men and women with HIV-1 infection, undergoing combination antiretroviral therapy (cART).MethodsA cross-sectional study was conducted in an unselected sample of 89 HIV-1-positive, non-diabetic patients undergoing stable cART for at least 6 months. Metabolic parameters were measured, including fasting plasma insulin, and circulating adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) levels. Insulin resistance was estimated by measuring the Quantitative Insulin Sensitivity Check Index (QUICKI), using a cut-off value of 0.33. A linear regression model was fitted to QUICKI to test the association of IR and adipokines levels.ResultsA total of 89 patients (aged 18–65, median: 28 years) including 51 men (57.3%) and 38 women (42.7%) were included in the study. Fifty nine patients (66.3%) were diagnosed with IR based on QUICKI values lower than the cut-off point. IR prevalence was 72.5% in men and 57.6% in women. The presence of the IR was not influenced by either the time of the HIV diagnosis or by the duration of cART. Decreased adiponectin and increased serum triglycerides were associated with increased IR in men (R=0.43, p=0.007). Hyperleptinemia in women was demonstrated to be associated with the presence of IR (R=0.33, p=0.03).ConclusionsGiven the significant prevalence of the IR in our young non-diabetic cohort with HIV infection undergoing antiretroviral therapy reported in our study and the consecutive risk of diabetes and cardiovascular events, we suggest that the IR management should be a central component of HIV-infection therapeutic strategy. As adipokines play major roles in regulating glucose homeostasis with levels varying according to the sex, we suggest that further studies investigating adipokines should base their analyses on gender differences.

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Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV‐1‐infected South African women

Cited by 13 publications

References 47 publications

Leptin expression in HIV-infected patients during antiretroviral therapy

Leptin expression in HIV-infected patients during antiretroviral therapy

HIV-1 and GBV-C co-infection in Venezuela

Insulin resistance and adipokines serum levels in a caucasian cohort of hiv-positive patients undergoing antiretroviral therapy: a cross sectional study

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