Association between hla and cutaneous necrotizing venulitis

Glass, David N.; Soter, Nicholas A.; Gibson, David J.; Carpenter, Charles B.; Schur, Peter H.

doi:10.1002/art.1780190519

Cited by 20 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this may reflect linkage of a disease susceptibility factor to HLA, the findings are also consistent with a direct effect of one or both of the antigens A 11 and B35 on disease expression. Support for this speculation is found in the reported association between A1 1 and B35 and the occurrence of necrotizing cutaneous venulitis (25) and the recently described association between B35 and nonstreptococcal glomerulonephritis (26). In both of these condition, as in SLE, immune complex deposition appears to play an important pathogenetic role.…”

Section: Discussionmentioning

confidence: 80%

Familial lupus. family studies of hla and serologic findings

Cleland

Bell

Willans

et al. 1978

Arthritis & Rheumatism

View full text Add to dashboard Cite

HLA profiles in 103 members of 4 separate kindred with multiple occurrence of SLE were compatible with the presence of a disease susceptibility factor linked to HLA or a direct effect of antigens B8, A l l , and B35 on disease expression. Serum ANA was found in 52.9% of consanguineous, 56.5% of nonconsanguineous relatives of SLE probands, and 5% of controls, a finding that suggests the presence of a transmissible agent in the families. By contrast, lymphocytotoxic antibodies were not increased in relatives compared to controls.The familial occurrence in SLE is well documented and was recently reviewed (1).Both genetic and environmental factors have been implicated in the occurrence of SLE. The greater concordance for SLE in monozygous compared to dizygous twins (2) and the influence of genetic factors in the murine form of the disease (3) probands has been documented in several large studies (4-9) but no clear pattern of inheritance has been established. On the other hand, a high incidence of cold lyrnphocytotoxic antibodies in the consanguineous and nonconsanguineous relatives of SLE probands (10,ll) suggests a role for a transmissible agent in the occurrence of SLE.Although studies of HLA profiles in patients with sporadically occurring SLE have produced weak or negative associations with HLA antigens (12-17), the possibility of a lupus susceptibility factor linked to the major histocompatibility complex (M HC) has not been excluded. The present study was designed to determine whether the expression of disease among indentified family clusters of SLE was in any way related to the MHC. MATERIALS AND METHODSFamilies with multiple occurrence of SLE were selected for study. All available family members were interviewed by one of the authors and available medical records were reviewed. Tissue typing was performed on ficoll separated peripheral blood mononuclear cells (18) using UCLA Research Tray T8 (PI Terasaki, Department of Surgery, UCLA). Serum antinuclear antibody (ANA) was detected in sera routinely diluted 1 : 10 in saline using a standard immunofluorescent technique with peripheral blood leukocytes as substrate (19). Serum immunoglobulin (Ig) levels were quantitated using commercially available immunodiffusion plates (Kent Laboratories, Vancouver, British Columbia). Mean f 2 SD range was: IgG 710-1540 mg/dl, IgA 50-490 mg/dl, IgM

show abstract

Section: Discussionmentioning

confidence: 80%

Familial lupus. family studies of hla and serologic findings

Cleland

Bell

Willans

et al. 1978

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Significant numbers of patients with SLE and CNV were found to have LCTAB, whereas few patients with J R A were found to have these antibodies, when compared t o normals. Table 1 divides the patients with C N V into two groups: those with vascular disease restricted to the skin and those in whom the vasculitis was associated with either SLE, rheumatoid arthritis, or Sjogren's syndrome (18). We expected to find these antibodies in the group of patients with the concomitant rheumatic disease.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, examination of the HLA phenotypes of the target lymphocytes excluded the possibility that the pattern of killing by the sera with LCTAB represented an HLA antibody. Sera were selected from 369 patients with rheumatic diseases studied at the Robert B. Brigham Hospital (18,(20)(21)(22)(23) and members of their families who had been HLA typed and had had complement profiles and ANAs performed. Of immediate family members-siblings, parents, and children-89% were studied.…”

Section: Lymphocytotoxic Antibodiesmentioning

confidence: 99%

Lymphocytotoxic antibodies

Raum

Glass

Soter

et al. 1977

Arthritis & Rheumatism

Self Cite

View full text Add to dashboard Cite

Lymphocytotoxic antibodies (LCTAB) were sought in sera of patients with rheumatic diseases and in family members. Patients with SLE and cutaneous necrotizing venulitis and family members of JRA patients had an increased frequency of LCTAB; JRA patients and family members of SLE patients did not. The only association between LCTAB and the HLA phenotype of persons with LCTAB was a decreased frequency of LCTAB in individuals with HLA-B27.Lymphocytotoxic antibodies (LCTAB) that react maximally at 15°C have been described in patients with rheumatic diseases (1-3), particularly in those with systemic lupus erythematosus (SLE) (4) and in members of their families (5). Because LCTAB were detected in a variety of conditions caused by certain viruses ( 6 ) as well as after immunization (7,8), their presence may serve as a marker of exposure to environmental agents. NecroFrom the Robert B. Brigham

show abstract

“…HLA-Bw35 has been associated with two disease populations in which an immunopathology is manifest-patients with glomerular nephritis with IgA mesengial deposits and those with a small vessel (venular) vasculitis (17,18). It may be of additional interest that IgA deficiency has been reported in JRA (19).…”

Section: Discussionmentioning

confidence: 99%