Association between HLA‐DQA1, HLA‐DQB1 and oral cancer

Abstract

Cancer is one of the most common causes of morbidity and mortality. Genes whose products play a critical role in regulation of the immune response include the HLA antigen and cytokine families of genes. Oral cancer is common in men in developing countries, and its frequency is increased by using betel-quid, tobacco, and alcohol. The association between certain HLA Class I and Class II haplotypes and cancer has been documented in a variety of tumors. There was no previous data concerning the association of specific HLA Class II DQA1, DQB1 alleles, or haplotypes with oral cancer patients. In this study, we enrolled 134 Taiwanese patients with histologically confirmed oral cancer and 268 age- and gender-matched healthy Taiwanese adults as control group to investigate the association between HLA-DQA1, HLA-DQB1 allele frequencies and oral cancer patients by using polymerase chain reaction with sequence-specific primers. We found that both HLA-DQA1* and HLA-DQB1* allele frequencies in oral cancer patients revealed no significant difference from those of control groups. Haplotype frequencies of HLA*DQA1-0103-DQB1*0601 in oral cancer patients were significantly lower than those of the control group (odds ratio: 0.18, 95% confidence interval: 0.054-0.583, p(c)=0.02). Our data suggest that HLA DQA1*0103-DQB1*0601 haplotype may be protective with regard to the development of oral cancer.

HLA gene polymorphism is a modifier of age-related breast cancer penetrance in carriers of BRCA1 pathogenic alleles

“…Our data obtained for HLA-DQB1*06:03P allele are consistent with the results of some case-control studies. In particular, the protective role of DQB1*06:03P variant was demonstrated for cervical cancer [30][31][32][33] and oral cavity tumors [34]. Both cervical and oral cavity cancers are associated with HPV infection, which may explain the role of the HLA-DQB1*06:03P allele.…”

Early-onset ovarian cancer: a comprehensive analysis

“…In addition, we identi ed signi cantly associated HLA-DQA1*01:03 risk allele and HLA-DQA1*03:03 protective allele. However, the cancer risk associations of HLA-DQA1 are contradictory and not very well understood yet [22,59,60] In addition to the speci c disease-related risk HLA alleles, also heterogeneity of inherited HLA alleles seems to be important with regard to tumor-associated antigen presentation, cancer cell recognition and elimination, as well as to immunoediting in early cancer development through e.g. stronger selective pressure on driver mutations in tumors [57].…”

Leveraging a disulfidptosis-related signature to predict the prognosis and immunotherapy effectiveness of cutaneous melanoma based on machine learning

“…In the case of esophageal cancer, high levels of HLA-DQA1 expression are associated with clinical characteristics and prognosis of esophageal squamous cell carcinoma (Shen et al 2019 ). In oral cancer and breast cancer, HLA-DQA1 polymorphism is related to incidence, and high levels of expression are associated with better prognosis, offering potential biomarkers for prediction and treatment of oral cancer and breast cancer (Tsai et al 2011 ; Zhou et al 2023 ; Mahmoodi et al 2012 ). Furthermore, imaging models have shown promising predictive performance in predicting HLA-DQA1 expression levels, providing a basis for personalized prediction of HLA gene expression.…”