Association between HLA‐DQB1 alleles and risk for cervical cancer in African‐American women

Grégoire, Lucie; Lawrence, W. Dwayne; Kukuruga, Debra; Eisenbrey, A. Bradley; Lancaster, Wayne D.

doi:10.1002/ijc.2910570411

Cited by 98 publications

(66 citation statements)

References 25 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Given the pivotal role of HLA molecules in the recognition of foreign peptides, several studies have been performed to examine the association of specific HLA alleles with HPV infection status and development of cervical cancer. In 1991, the HLA-DQw3 antigen was reported to be associated with cervical cancer in a German cohort, 4 and later studies in Spanish, 5 British 6 and African-American cohorts 7 showed similar results. Other HLA alleles have also been proposed to increase the risk of cervical cancer: DRB1*1501, 5,8 DRB1*04 and DRB1*11.…”

supporting

confidence: 67%

HLA class II alleles associated with infection by HPV16 in cervical cancerin situ

2001

View full text Add to dashboard Cite

HLA class II alleles have been associated with an increased risk of developing cervical cancer through infection with oncogenic forms of human papilloma virus (HPV). We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective casecontrol study. The infection history of a woman was studied by analysis of cervical smears taken at multiple times during a period of up to 27 years (1969 -95 Key words: HLA; HPV; cervical cancerInfection with oncogenic forms of human papillomavirus (HPV) is the major etiologic factor for the development of cervical cancer. Using sensitive detection methods, oncogenic HPVs have been found in almost every cervical tumor. 1,2 However, infection with oncogenic HPVs is common among women having normal cytology, 3 mild lesions regress without intervention and most infections are cleared spontaneously. This implies that factors determining the course of an HPV infection contribute to the risk of developing cervical cancer. Such factors may include the inherent ability to respond to HPV infection.It has been suggested that differences in the immune response to HPV affect whether an HPV infection is cleared or becomes persistent. 4 Given the pivotal role of HLA molecules in the recognition of foreign peptides, several studies have been performed to examine the association of specific HLA alleles with HPV infection status and development of cervical cancer. In 1991, the HLA-DQw3 antigen was reported to be associated with cervical cancer in a German cohort, 4 and later studies in Spanish, 5 British 6 and African-American cohorts 7 showed similar results. Other HLA alleles have also been proposed to increase the risk of cervical cancer: DRB1*1501, 5,8 DRB1*04 and DRB1*11. 9 A number of alleles that are less common in patients relative to controls have also been reported, e.g., DRB1*1301, 8 DQB1*0501 9 and DQB1*0603. 5 An increased risk for HPV16-associated cervical cancer has been reported for the DRB1*1501-DQB1*0602 haplotype, 10 the DQA1*0102-DQB1*0602 haplotype 11 and for the DRB1*0701 allele. 12,13 Finally, an HPV16-specific protective effect for DR13 alleles has been reported. 10 While a direct comparison between these studies is somewhat difficult due to differences in cancer stage studied, laboratory methods and study population, they indicate an effect of HLA alleles on risk of cervical cancer. In our study, we have used a large case-control material to investigate the association of HLA class II alleles with infection by HPV16 and to the risk of developing cervical cancer in situ. Our results show that HLA class II alleles are associated primarily with infection of HPV and only secondarily with cervical cancer. MATERIAL AND METHODS SubjectsThe participants in our study were selected from a cohort of women residing in Uppsala County, Sweden, between 1969 -95. 14 The participants had to fulfill the follow...

show abstract

supporting

confidence: 67%

HLA class II alleles associated with infection by HPV16 in cervical cancerin situ

2001

View full text Add to dashboard Cite

show abstract

“…To date, most studies have demonstrated that DQB1*03 (DQB1*0301, DQB1*0302, and DQB1*0303) is positively correlated with cervical cancer and increases its risk (Madeleine et al, 2002). This finding has been confirmed in populations in Norway (Helland et al, 1994), Japan (Nawa et al, 1995), France (Sastre-Garau et al, 1996), and an African American community (Gregoire et al, 1994). One study involving Spanish women in New Mexico also demonstrated that HPV16-positive cervical cancer patients exhibited increased DQB1*0303 expression (Apple et al, 1994).…”

Section: Introductionmentioning

confidence: 85%

Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were genotyped using polymerase chain reaction-sequence-based typing (PCR-SBT) for HLA-DQB1. Two hundred and ninety-six alleles were identified among the 160 cases. One hundred and thirty-six alleles were heterozygous and 24 were homozygous. Using frequency calculations and statistical analysis, we found that HLA-DQB1*0325

show abstract

“…The most consistent published evidence to date involves the HLA-DQB1*03 (DQ3) allele and HLA-DRB1*1501-DQB1*0602 haplotype. Increased risks (approximately 2-fold) for cervical cancer or malignant precursor lesions have been identified in different populations for HLA-DQB1*03 (DQ3) allele [7][8][9][10][11][12][13] or HLA-DRB1*1501-DQB1*0602 12,14-17 haplotype carriers. Other studies did not show any association with HLA-DQB1*03 [15][16][17][18][19] or HLA-DRB1*1501-DQB1*0602.…”

mentioning

confidence: 99%

Selected class I and class II HLA alleles and haplotypes and risk of high‐grade cervical intraepithelial neoplasia

Ades

Koushik

Duarte-Franco

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

Human leukocyte antigens (HLAs) present foreign antigens to the immune system and may be important determinants of cervical neoplasia. Previously published associations between HLA and cervical neoplasia exhibit considerable variation in findings. The biomarkers of cervical cancer risk (BCCR) case-control study addressed the role of specific HLA alleles as cofactors in the development of high-grade cervical intraepithelial neoplasia (HG-CIN) based on the most consistent evidence from published literature. Cases (N 5 381) were women with histologically-confirmed HG-CIN attending colposcopy clinics and controls (N 5 884) were women from outpatient clinics with normal cytological screening smears. Subjects were mainly of French-Canadian descent. Cervical specimens were tested for human papillomavirus (HPV) DNA and HLA genotypes by PGMY L1 consensus primer PCR and a PCR sequence-specific primer method, respectively. Unlike other studies, the DQB1*03 and DRB1*13 allele groups were not associated with risk of HG-CIN. The B7-DRB1*1501-DQB1*0602 haplotype was associated with a 41% overall reduction in HG-CIN risk (odds ratio [OR] 5 0.59; 95% confidence interval [CI]: 0.36-0.96), and an 83% reduction in risk of HG-CIN among HPV 16 or HPV 18-positive subjects (OR 5 0.17; 95%CI: 0.05-0.54). Paradoxically, however, the same haplotype was associated with HPV 16/18 infection risk among controls (OR 5 8.44, 95%CI: 1.12-63.73). In conclusion, the B7-DRB1*1501-DQB1*0602 haplotype was protective against HG-CIN, especially in individuals infected with oncogenic HPV, but the mechanism of the association seems to involve multiple steps in the natural history of HPV and CIN. ' 2008 Wiley-Liss, Inc.Key words: cervical intraepithelial neoplasia; human leukocyte antigen; human papillomavirus; case-control study After breast cancer, cervical cancer is the second most common cancer in women worldwide, with 493,000 new cases and over 273,000 deaths annually. 1 It is well established that the cervical infection caused by one of up to 18 oncogenic human papillomaviruses (HPV) is the main causal factor in cervical cancer, with HPV 16 alone accounting for over half of all cases. 2 In fact, HPV infection can be considered a necessary intermediate step in cervical carcinogenesis. 3 On the other hand, despite the presence of asymptomatic cervical HPV infection in 5-50% of women of reproductive age, 4,5 only a small fraction of infected women will develop cervical cancer. Thus, HPV infection alone is not a sufficient cause of cervical cancer, which underscores the need to identify cofactors that may mediate risk of persistent HPV infection or progression to cervical dysplastic changes and overt neoplasia. The human leukocyte antigens (HLA) mediate the presentation of HPV antigens to the immune system and thus may either predispose to or protect against development of HPV-associated cervical neoplasia. 6 Previous case-control studies examining the relationship have suggested that certain HLA polymorphisms are associated with risk of neoplastic tran...

show abstract

Association between HLA‐DQB1 alleles and risk for cervical cancer in African‐American women

Cited by 98 publications

References 25 publications

HLA class II alleles associated with infection by HPV16 in cervical cancerin situ

HLA class II alleles associated with infection by HPV16 in cervical cancerin situ

Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer

Selected class I and class II HLA alleles and haplotypes and risk of high‐grade cervical intraepithelial neoplasia

Contact Info

Product

Resources

About