Association between HLA-DRB1*04 and Malay patients with Vogt-Koyanagi-Harada syndrome in Malaysia: A case-control study

Abstract

Introduction: Vogt-Koyanagi-Harada (VKH) is an autoimmune disorder affecting melanocyte-containing tissues. Major histocompatibility complex, class II, DR beta1 (HLA-DRB1)*04 and its suballele HLA-DRB1*0405 were found to be associated with VKH in many studies.Purpose: To determine the association of HLA-DRB1*04 and its suballele HLADRB1*0405 with VKH patients of Malay descent.Materials and methods: A case control study was conducted among VKH patients of Malay ethnicity attending Ophthalmology Clinic, Hospital Selayang, Malaysia from December 2016 to December 2017. HLA-DRB1*04 allele-specific typing was performed on 14 Malay patients with VKH and 14 healthy controls using the polymerase chain reaction sequence-specific primer method. The data was then analysed using Fisher’s Exact test.Results: The frequency of HLA-DRB1*04 was noted to be higher in patients (42.9%) compared to controls (14.3%), but was not statistically significant (p = 0.209). The frequency of suballele HLA-DRB1*0405 was also increased in patients (42.9%) vscontrols (7.1%); however, the results were not significant (p = 0.077).Conclusion: In conclusion, although the findings were not statistically significant, the increased frequency of both HLA-DRB1*04 and its suballele HLA-DRB1*0405 may suggest a possible cause for the development of VKH among Malay patients.

Vogt-Koyanagi-Harada Disease: The Clinical Spectrum and Management of Case Series in a Tertiary Eye Centre in Northern Part Of Malaysia

“…Vogt-Koyanagi-Harada disease is an important cause of panuveitis, affecting, more frequently, pigmented skin individuals such as Amerindian, Hispanic [12,13], and Asian patients, including those from Japan [6], Singapore [10], and Malaysia [8]. K. Diallo et al, who conducted a multicentric study in France, found that North African was the primarily represented ethnicity 58%, followed by Southeast Asian 49%, Caucasian 20%, and Hispanic 2% [13].…”

“…This disease has a strong genetic association with HLA-DRB1*0405 [5][6][7]. Eye involvement is usually bilateral [8,9] rather than unilateral.…”