Association between HLA-G 14bp Gene Polymorphism and Serum sHLA-G Protein Concentrations in Preeclamptic Patients and Normal Pregnant Women

Rokhafrooz, Saber; Ghadiri, Ata; Ghandil, Pegah; Boroujerdnia, Mehri Ghafourian; Hossaini, Seyed Hojjat; Daraei, Nahid; Najafian, Mahin; Rouhizadeh, Ahmad

doi:10.1080/08820139.2018.1467925

Cited by 30 publications

(18 citation statements)

References 38 publications

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“…Hylenius et al reported that paternal inheritance of a 14-bp deletion/insertion in HLA-G can be important for PE onset 13 . However, several follow-up studies failed to support the findings of Hylenius et al [14][15][16][17] . Among those studies, Larsen et al found that the 14-bp deletion/insertion polymorphism (rs371194629) accompanying other polymorphisms in exon 8 (rs1710, rs1063320, rs9380142, and rs1610696) was associated with PE in the primipara when the fetus was homozygous for the insertion 18 .…”

mentioning

confidence: 90%

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Nishizawa¹,

Kumada²,

Tateno³

et al. 2020

Sci Rep

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Preeclampsia is a pregnancy-induced disorder that is characterized by hypertension and is a leading cause of perinatal and maternal–fetal morbidity and mortality. HLA-G is thought to play important roles in maternal–fetal immune tolerance, and the associations between HLA-G gene polymorphisms and the onset of pregnancy-related diseases have been explored extensively. Because contiguous genomic sequencing is difficult, the association between the HLA-G genotype and preeclampsia onset is controversial. In this study, genomic sequences of the HLA-G region (5.2 kb) from 31 pairs of mother–offspring genomic DNA samples (18 pairs from normal pregnancies/births and 13 from preeclampsia births) were obtained by single-molecule real-time sequencing using the PacBio RS II platform. The HLA-G alleles identified in our cohort matched seven known HLA-G alleles, but we also identified two new HLA-G alleles at the fourth-field resolution and compared them with nucleotide sequences from a public database that consisted of coding sequences that cover the 3.1-kb HLA-G gene span. Intriguingly, a potential association between preeclampsia onset and the poly T stretch within the downstream region of the HLA-G*01:01:01:01 allele was found. Our study suggests that long-read sequencing of HLA-G will provide clues for characterizing HLA-G variants that are involved in the pathophysiology of preeclampsia.

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mentioning

confidence: 90%

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Nishizawa¹,

Kumada²,

Tateno³

et al. 2020

Sci Rep

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“…Soluble HLA-G has been detected in plasma or serum not only from pregnant women but also from nonpregnant ones; however, the concentration of sHLA-G was higher in blood from pregnant than that from non-pregnant women. In addition, sHLA-G levels were higher in the first trimester of pregnancy compared to the second and third trimesters (19), while low levels of sHLA-G have been detected in recurrent miscarriage (20), miscarriage in IVF pregnancies (21), as well as preeclampsia (22). In addition, HLA-G as an important mediator of immune escape has been also described in other immunemediated disorders, malignancies, and transplantation (23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 97%

Association of Soluble HLA-G Plasma Level and HLA-G Genetic Polymorphism With Pregnancy Outcome of Patients Undergoing in vitro Fertilization Embryo Transfer

Nowak

Wilczyńska

Radwan³

et al. 2020

Front. Immunol.

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“…Maternal serum with higher levels of sHLA-G has been identified in females with successful pregnancy when compared with pre-eclampsia patients [24]. Lower sHLA-G levels in the maternal blood, with down regulated HLA-G and decreased proportion of HLA-G+ cells have been identified in patients with preeclampsia and are thought to be are strongly associated with preeclampsia [24][25][26]. The 14 bp ins/del in the 3′UTR of region exon 8 have been extensively studied, and it has been reported to be related to severe pre-eclampsia [15].…”

Section: Hla-g and Pregnancy Disordersmentioning

confidence: 99%

“…The 14 bp ins/del in the 3′UTR of region exon 8 have been extensively studied, and it has been reported to be related to severe pre-eclampsia [15]. But on the contrary, there are studies which have reported no significant association of the 14 bp polymorphism with preeclampsia [24][25][26] implicating that differences in the ethnic population should be considered for the association between HLA-G 14 bp polymorphism and serum sHLA-G level. The SNP at position +3172 (G/A) leading to decreased in mRNA stability has been linked to pre-eclampsia [19].…”

Section: Hla-g and Pregnancy Disordersmentioning

confidence: 99%

Alloimmunization and Role of HLA in Pregnancy

Singh¹,

Rajak²,

Rajadhyaksha³

2019

Complications of Pregnancy

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Alloimmunization also known as isoimmunization, during pregnancy is the production of IgG antibodies by the mother against the paternally inherited antigens (IPA) in the foetus/newborn. The alloimmunization during pregnancy leads to various alloimmune disorders, such as, haemolytic disease of the foetus and newborn (HDFN), neonatal alloimmune neutropenia (NAN) and foetal and neonatal alloimmune thrombocytopenia (FNAIT) due to the production of maternal alloantibodies against the red blood cell antigen, neutrophils and platelets cell antigens, respectively. Recent studies suggest that maternal anti-HLA class I alloantibodies may also be the cause of FNAIT in addition to antibodies against platelet antigens. On the contrary, studies have also suggested that HLA-C, a classical HLA class I molecule, and HLA-G, a nonclassical HLA molecule, play an important role in placentation and modulation of the maternal immune system during pregnancy, respectively, and thereby leading to acceptance of the semi allogeneic fetus. So far most of the studies have discussed alloimmunization in pregnancy relating to Rh antigen. Thus, in this chapter an attempt has been made to discuss alloimmunization in pregnancy caused because of maternal alloantibody against HLA antigen and its role in immune modulation during pregnancy.

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Association between HLA-G 14bp Gene Polymorphism and Serum sHLA-G Protein Concentrations in Preeclamptic Patients and Normal Pregnant Women

Cited by 30 publications

References 38 publications

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia

Association of Soluble HLA-G Plasma Level and HLA-G Genetic Polymorphism With Pregnancy Outcome of Patients Undergoing in vitro Fertilization Embryo Transfer

Alloimmunization and Role of HLA in Pregnancy

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