Association between homocysteine and third ventricle dilatation, mesencephalic area atrophy in Parkinson’s disease with cognitive impairment

Fu, Xin; Zhang, Ying Chun; Ding, Chang Wei; Yang, Min; Song, Xiangfeng; Wang, Cai Shan; Chen, Xiao Fang; Sheng, Yu; Mao, Pan; Mao, Cheng Jie; Liu, Chun‐Feng

doi:10.1016/j.jocn.2021.06.006

Cited by 7 publications

(8 citation statements)

References 28 publications

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“… 14 Fu et al showed that PD patients with cognitive impairment exhibited the highest Hcy levels compared with sex- and age-matched controls and PD patients with normal cognition, suggesting that Hcy played a role in the pathophysiological of cognitive impairment among PD patients. 17 Dong et al also showed that plasma Hcy levels of PD patients were significantly increased compared with healthy controls in China, and moreover the cognitive status of PD patients could influence plasma Hcy levels. 42 However, some reports have demonstrated the opposite results.…”

Section: Discussionmentioning

confidence: 99%

“…11 Elevated plasma Hcy levels (≥15µmol/L), defined as hyperhomocysteinemia, can have toxic effects on blood vessels and neurons, including oxidative damage and endothelial dysfunction. It is well-established that plasma Hcy levels elevate significantly in PD patients compared with healthy controls, [12][13][14][15][16][17] which can increase the risk for cognitive impairment and brain atrophy of PD patients. [15][16][17] However, some reports show that hyperhomocysteinemia is not correlated with cognitive deterioration, neuropsychiatric disorders, depression and dementia among PD patients.…”

Section: Introductionmentioning

confidence: 99%

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Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson’s Disease

Zhang¹,

Li²,

Wang³

2023

IJGM

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Purpose To verify the associations between white matter hyperintensities (WMHs), plasma homocysteine (Hcy) levels, and mild cognitive impairment (MCI) in Parkinson’s disease (PD) patients and evaluate the predictive value of combination of WMHs and plasma Hcy levels for MCI. Patients and methods In this study, 387 patients with PD were divided into MCI group and non-MCI group. Their cognition was evaluated with a comprehensive neuropsychological evaluation including 10 tests. Five cognitive domains, including the memory, attention/working memory, visuospatial, executive and language domains, were evaluated using two tests for each domain. MCI was determined when at least two tests demonstrated abnormal results, either one impaired test in two different cognitive domains or two impaired tests in a single cognitive domain. Multivariate analysis was performed to determine risk factors for MCI in PD patients. The receiver operating characteristic (ROC) curve was employed to assess the predictive values, and the Z test was employed to compare the area under curve (AUC). Results MCI was identified in 195 PD patients with an incidence of 50.4%. Multivariate analysis results showed that PWMHs (OR: 5.162, 95% CI: 2.318~9.527), Hcy levels (OR: 1.189, 95% CI: 1.071~1.405) and MDS-UPDRS part III score (OR: 1.173, 95% CI: 1.062~1.394) were independently correlated with MCI in PD patients after adjusting for confounders. ROC curves showed that the AUCs of PWMHs, Hcy levels and their combination were 0.701 (SE: 0.026, 95% CI: 0.647~0.752), 0.688 (SE: 0.027, 95% CI: 0.635~0.742) and 0.879 (SE: 0.018, 95% CI: 0.844~0.915), respectively. Z test showed that the AUC of combination prediction was significantly higher than those of individual predictions (0.879 vs 0.701, Z =5.629, P <0.001; 0.879 vs 0.688, Z =5.886, P <0.001). Conclusion The combination of WMHs and plasma Hcy levels could be applied in the prediction of MCI in PD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson’s Disease

Zhang¹,

Li²,

Wang³

2023

IJGM

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“…Serum homocysteine level was significantly high in PD patients, and that level was correlated with brain atrophy 30 . Higher homocysteine level correlated with larger size of the third ventricle and less volume of mesencephalon 31 . Cognitive decline in PD patients was reported to show higher homocysteine level, lower folate and vitamin B12 levels, although it is unveiled the role of homocysteine in the cognitive decline 32 .…”

Section: Discussionmentioning

confidence: 99%

“… 30 Higher homocysteine level correlated with larger size of the third ventricle and less volume of mesencephalon. 31 Cognitive decline in PD patients was reported to show higher homocysteine level, lower folate and vitamin B12 levels, although it is unveiled the role of homocysteine in the cognitive decline. 32 Homocysteine has been reported to be a risk factor for cardiovascular and neurodegenerative diseases, acting by several mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Impact of constipation on progression of Alzheimer's disease: A retrospective study

et al. 2022

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Background and Purpose In terms of the gut‐brain axis, constipation has been considered to be an important factor of neurodegenerative diseases, although the exact mechanism is still controversial. Herein, we aimed to investigate the contribution of constipation to the progression of dementia in a retrospective study. Methods Patients of Alzheimer's disease(AD) and amnestic mild cognitive impairment were consecutively screened between January 2015 and December 2020, and those of whom brain MRI and neuropsychological tests were performed twice were enrolled in this study. Participants were classified into with constipation (Cons[+], n = 20) and without constipation (Cons[−], n = 64) groups. Laboratory data at the first visit were used. Regression analysis was performed in MMSE, ADAS‐Cog, and the volumes of hippocampus on MRI‐MPRAGE images and deep white matter lesions (DWMLs) on MRI‐FLAIR images obtained at two different time points. Results The main finding was that the Cons[+] group showed 2.7 times faster decline in cognitive impairment compared with the Cons[−] group, that is, the liner coefficients of ADAS‐Cog were 2.3544 points/year in the Cons[+] and 0.8592 points/year in the Cons[−] groups. Ancillary, changes of DWMLs showed significant correlation with the time span (p < 0.01), and the liner coefficients of DWMLs were 24.48 ml/year in the Cons[+] and 14.83 ml/year in the Cons[−] group, although annual rate of hippocampal atrophy was not different between the two groups. Moreover, serum homocysteine level at baseline was significantly higher in the Cons[+] group than Cons[−] group (14.6 ± 6.4 and 11.5 ± 4.2 nmol/ml, respectively: p = 0.03). Conclusion There is a significant correlation between constipation and faster progression of AD symptoms along with expansion of DWMLs.

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“…[5][6][7] Therefore, blood Hcy is an important indicator of human health and when levels in plasma reach 6.3 μM, it represents a high risk of cardiovascular or cerebrovascular events and when these levels reach 10 μM, the incidence of the above events increases 2-fold. Moreover, some studies have reported an association between high serum Hcy levels and Parkinson's disease (PD) 8 or Alzheimer's disease (AD). 9,10 It is necessary therefore to determine the Hcy content in the human body using an appropriate methodology.…”

Section: Introductionmentioning

confidence: 99%

Development of a colloidal gold strip assay for the detection of total homocysteine in serum samples

ang

et al. 2022

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Association between homocysteine and third ventricle dilatation, mesencephalic area atrophy in Parkinson’s disease with cognitive impairment

Cited by 7 publications

References 28 publications

Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson’s Disease

Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson’s Disease

Impact of constipation on progression of Alzheimer's disease: A retrospective study

Development of a colloidal gold strip assay for the detection of total homocysteine in serum samples

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