Association between human papillomavirus and prostate cancer: A meta-analysis

Yin, Binbin; Liu, Weiwei; Pan, Yu; Liu, Chunhua; Chen, Yue; Duan, Xin; Liao, Zhaoping; Chen, Yuhua; Wang, Xuchu; Pan, Xiaoyan; Tao, Zhihua

doi:10.3892/ol.2017.6367

Cited by 31 publications

(24 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The detected high frequency of high-risk HPVs in the investigated Bulgarian prostatic tumor-specific specimens with molecular alterations is in accordance with the reported data in Europe and confirms the hypothesis for the participation of HPV as an inflammatory cofactor in the complex etiology of PCa [40]. The prevalence of HPVs from the subgroup with highest oncogenic potential provides another evidence for the role of the viral component in the initiation and even progression of PCa.…”

Section: Discussionsupporting

confidence: 89%

Investigation of Noninvasive Urine Specimens with Molecular Fluctuations for a Presence of High-Risk Human Papilloma Viruses as an Inflammatory Cofactor in the Prostate Cancer

Kavrakova¹,

Georgieva²,

Anachkov³

et al. 2018

Biol Med

View full text Add to dashboard Cite

Background: The aim of the study is to investigate noninvasive urine specimens in suspected prostate cancer (PCa) patients by a panel of PCA3, TMPRSS2-ERG fusions and GSTP1 promoter hypermethylation. Furthermore, we tested urine specimens for the presence of high-risk Human Papilloma Viruses (HPV) as an inflammatory cofactor in the complicated origin of prostate cancer (PCa). Methods: A total of 50 patients with elevated PSA and/or PCa physiological symptoms were analyzed. RNA and DNA isolation; Reverse transcription; Real-time PCR; DNA sequencing; Bisulfite conversion of DNA; Methylationspecific PCR; Cytological preparations and staining were applied. Results: Molecular fluctuations were registered in most of the patients: neoplastic GSTP1 allele, PCA3 strongly elevated expression or hyperexpression. Only in 4 cases a positive TMPRSS2-ERG status was detected. High-risk HPV types were detected in ~ 35% of our urine specimens, obtained from patients at high risk of PCa based on their molecular profiles. Approximately 96% of detected high-risk HPVs are: 16, 33, 35, 31, distributed in the subgroup with highest oncogenic potential. The estimated frequency of high-risk HPV types in control male samples with urothelial infection is significantly lower (11%). The pathological examination on cytological slides from high-risk HPV positive urine specimens showed inflammation; variable adaptations of cellular growth and differentiation and partially viral cytopathic effect. In a proportion of patients with molecular PCa disturbed profile precancerous conditions (increased primitive cells with disturbed maturation; enlarged hyperchromatic nucleus and condensed chromatin) were found. Conclusion: Our molecular PCa findings, were confirmed on the cellular level with cytological findings of high grade alterations: coarse distributed chromatin texture with nuclear membrane irregularity and thickening; high N:C Ratio; prominence of nucleoli and irregularity in shape thereof; identical monotonous nucleoli present in all cells in a group (i.e., "Clonal" pattern); Tumor diathesis. The present study concerns novel data for Bulgarian PCa patients.

show abstract

Section: Discussionsupporting

confidence: 89%

Investigation of Noninvasive Urine Specimens with Molecular Fluctuations for a Presence of High-Risk Human Papilloma Viruses as an Inflammatory Cofactor in the Prostate Cancer

Kavrakova¹,

Georgieva²,

Anachkov³

et al. 2018

Biol Med

View full text Add to dashboard Cite

show abstract

“…Chronic prostate inflammation (that could be induced by a viral infection) is thought to increase the risk of prostate cancer (436), and a link between prostate cancer, sexual activity and sexually-transmitted infection was reported in some studies (306). However, despite years of investigations on HPV (3,35,301,675,756,760), KSHV, EBV, BK virus, CMV (3, 301), and the "rumor" virus Xenotropic murine leukemia related virus (XMRV) (531) through serology testing or prostate tissue analysis by PCR, in situ hybridization or immunohistochemistry, there is no compelling evidence for a viral etiology of prostate cancer. Nevertheless, a few studies suggested that KSHV and HPV may represent a risk factor for prostate cancer aggressiveness (239,494,756).…”

Section: Prostate Cancermentioning

confidence: 99%

From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract

Tortorec

Matusali

Mahé

et al. 2020

Physiological Reviews

103

View full text Add to dashboard Cite

The male genital tract (MGT) is the target of a number of viral infections that can have deleterious consequences at the individual, offspring, and population levels. These consequences include infertility, cancers of male organs, transmission to the embryo/fetal development abnormalities, and sexual dissemination of major viral pathogens such as human immunodeficiency virus (HIV) and hepatitis B virus. Lately, two emerging viruses, Zika and Ebola, have additionally revealed that the human MGT can constitute a reservoir for viruses cleared from peripheral circulation by the immune system, leading to their sexual transmission by cured men. This represents a concern for future epidemics and further underlines the need for a better understanding of the interplay between viruses and the MGT. We review here how viruses, from ancient viruses that integrated the germline during evolution through old viruses (e.g., papillomaviruses originating from Neanderthals) and more modern sexually transmitted infections (e.g., simian zoonotic HIV) to emerging viruses (e.g., Ebola and Zika) take advantage of genital tract colonization for horizontal dissemination, viral persistence, vertical transmission, and endogenization. The MGT immune responses to viruses and the impact of these infections are discussed. We summarize the latest data regarding the sources of viruses in semen and the complex role of this body fluid in sexual transmission. Finally, we introduce key animal findings that are relevant for our understanding of viral infection and persistence in the human MGT and suggest future research directions.

show abstract

“…The strong association was proven only for human papilloma virus (HPV) and penile cancer risk [ 10 ]. However, more and more research shows a possible link between viral infections and urothelial cancer [ 11 , 12 , 13 , 14 , 15 ], prostate cancer [ 15 , 16 , 17 ] or testicular cancer [ 18 , 19 ]. Furthermore, the evidence behind the role of latent viral infections in carcinogenesis of RCC is growing.…”

Section: Introductionmentioning

confidence: 99%

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Kryst

Poletajew

Wyczalkowska-Tomasik

et al. 2020

JCM

View full text Add to dashboard Cite

Background: There is growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic/latent viral infections with the clinical course of renal cell carcinoma (RCC). Methods: In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) from tumor tissue and using the EZ1 Virus Mini Kit v2.0 from plasma. The number of viral copies of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) in the tissue and plasma was assessed with real-time PCR. Results: Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival. Conclusions: EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.

show abstract

Association between human papillomavirus and prostate cancer: A meta-analysis

Cited by 31 publications

References 86 publications

Investigation of Noninvasive Urine Specimens with Molecular Fluctuations for a Presence of High-Risk Human Papilloma Viruses as an Inflammatory Cofactor in the Prostate Cancer

Investigation of Noninvasive Urine Specimens with Molecular Fluctuations for a Presence of High-Risk Human Papilloma Viruses as an Inflammatory Cofactor in the Prostate Cancer

From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Contact Info

Product

Resources

About