Association Between Human Papillomavirus Infection Among Pregnant Women and Preterm Birth

Abstract

IMPORTANCE Preterm birth remains a leading cause of perinatal mortality and lifelong morbidity worldwide. The cause of most preterm births is unknown, although several infectious processes have been implicated.OBJECTIVE To assess whether human papillomavirus (HPV) infection, a frequent infection among women of childbearing age, is associated with preterm birth.

Maternal HPV Infection: Effects on Pregnancy Outcome

“…Other authors reported comparable findings [62,94]. Furthermore, the more recent HERITAGE cohort study conducted by Niyibizi and colleagues looked at 899 pregnant women, and found that persistent HR-HPV infection led to a significant increase in the risk of preterm birth [95]. Likewise, the recently published retrospective population-based register study conducted by Wiik et al highlighted the increased risk of preterm delivery among women with HPV infection and/or cervical intraepithelial neoplasia (CIN), especially if previously treated [96].…”

Human Papillomavirus Infection Among Pregnant Women Living With HIV: A Systematic Review and Meta-Analysis

“…Meta-analysis of HPV infection during pregnancy and adverse pregnancy outcomes in the general population has documented a significant association between HPV detection during pregnancy and both preterm birth and preterm premature rupture of membranes. 7 As spontaneous preterm birth rates are elevated among WLWH, the unavailability of such data for WLWH is a critical knowledge gap that should be addressed and may illuminate the etiology of some adverse pregnancy outcomes within this population.…”

“…A recent meta-analysis of HPV infection during pregnancy and adverse pregnancy outcomes found a significant association between HPV detection during pregnancy and both preterm birth and premature rupture of membranes. 7 Given that WLWH experience higher rates of adverse pregnancy outcomes such as spontaneous preterm birth, the etiology of which is often unknown, improved understanding of HPV prevalence during pregnancy in this population is also important because of the suggested potential for HPV infection to affect the pregnancy outcome.…”

The Association Between Human Papillomavirus Infection and Preterm Labor: A Literature Mini-review

“…In recent years, different groups of investigators have suggested that HPV infection (especially those caused by HR-HPVs) is associated with an increased risk of preterm birth (22,(31)(32)(33). For instance, in a retrospective cohort study on 2153 women, Caballero et al announced HPV infection as a risk factor for preterm delivery resulting from the premature rupture of membranes (PROM) (33).…”