Association between human papillomavirus infection and laryngeal squamous cell carcinoma

Morshed, Kamal

doi:10.1002/jmv.21749

Cited by 71 publications

(74 citation statements)

References 25 publications

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“…Only data generated from primary squamous cell carcinomas (SCC) were extracted, and we excluded reports if: (1) the detection methods were not well-detailed, and/or (2) HPV data could not be extracted per anatomic site. We took care to avoid tallying overlapping patient cohorts [2][3][4][5][6][7][8][9][10][11][12][13]. The final extracted data included: county, year of publication, anatomical site, HPV type, detection method of including primers, and summary of findings for cancers, patient controls, benign lesions, potentially premalignant lesions, and premalignant lesions, when available.…”

Section: Methodsmentioning

confidence: 99%

“…Compared to oral carcinomas, a greater diversity of other HPV types has been detected: HPV18, HPV26, HPV31, HPV33, HPV39, HPV36, HPV45, HPV51, HPV52, HPV58, HPV59, HPV66, and HPV69 [8,9,14,20,26,29,39,65,71,90,94]. Low-risk HPV are uncommonly detected, and might represent incidental ''bystander'' rather than possibly ''driver'' infection [29,39,65,75,90,94].…”

Section: Hpv and Cancers Of The Larynxmentioning

confidence: 99%

“…Importantly, only four studies [8,9,29,88,95] examined the impact of HPV on the outcome of a total of 319 patients; 134 of which were HPVpositive. No association of HPV status with outcome was found.…”

Section: Hpv and Laryngeal Cancermentioning

confidence: 99%

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Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

228

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Section: Methodsmentioning

confidence: 99%

Section: Hpv and Cancers Of The Larynxmentioning

confidence: 99%

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Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

228

218

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“…Few studies have reported an association between HPV and HNSCC of the larynx [8,9] and other subsites [7]. Methods for testing tumor tissue for HPV are not standardized [10] and, moreover, there is little consensus on optimal treatment for HPV-associated HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival: A Comparison by Tumor Site and Initial Treatment

Salazar

Smith

Garg

et al. 2013

Head and Neck Pathol

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Recent evidence suggests that human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients have better survival than HPV-negative patients. However, it is unclear if similar patterns for survival exist across different tumor sites, and whether HPV-associated prognosis is modified by type of treatment. We prospectively tested 222 histologically confirmed HNSCC primary tumors for HPV DNA by PCR and HPV E6/E7 RNA by RT-PCR prior to treatment at a large urban health center. Cox proportional hazard ratio models were constructed to assess HPV-associated differences in overall and disease-specific survival adjusting for clinical and demographic covariates. HPV detection varied significantly by primary HNSCC tumor site, from 35 % for oropharynx, to 25 % for hypopharynx, 5 % for larynx, and 3 % for oral cavity (p \ 0.0001), with HPV16 accounting for the majority (95 %) of HPV-positive tumors. The hazard-risk of overall and disease-specific death comparing HPV16-positive versus negative oropharyngeal HNSCC was reduced by 74 and 89 %, respectively (p values \ 0.05), and was independent of other prognostic indicators; no statistically significant changes in outcomes were observed for non-oropharyngeal HNSCC sites. Prediction of overall survival was better with combined DNA and RNA HPV16 positive PCR detection. There was no difference in HPV16-associated survival whether patients received either surgery or (chemo)radiotherapy as their initial treatment modality. Improved HPV-associated HNSCC survival is limited to Electronic supplementary material The online version of this article

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“…Additionally, in 1994, Clayman et al also showed that HPV detection significantly correlated with decreased survival (Clayman et al, 1994). On the other hand, other studies have failed to demonstrate an association between HPV positivity and prognosis (Duray et al, 2011a;Ernoux et al, 2011;Koskinen et al, 2003;Morshed et al, 2010). From a biological point of view, it is difficult to explain why patients with HPV infections have a worse survival than HPV-negative patients.…”

Section: Prognosis Of Hpv Positive Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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Association between human papillomavirus infection and laryngeal squamous cell carcinoma

Cited by 71 publications

References 25 publications

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival: A Comparison by Tumor Site and Initial Treatment

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

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