Association between Hyperglycemia, C-Reactive Protein and Other Risk Factors in Patients at Cardiovascular Risk

Abstract

Type 2 diabetes (DM2) is a syndrome characterized by postprandial hyperglycemia normally due to peripheral resistance to insulin and accounts for approximately 90% of diabetes cases worldwide and it is usually related to dyslipidemia, overweight/obesity and physical inactivity and increase in the risk of cardiovascular disease. This study aimed to compare the metabolic and inflammatory profile of hyperglycemic with non-hyperglycemic subjects in a group of patients undergoing coronary arteriography. Our group of patients showed that 63.16% presented glycaemia above 99 mg/dL (from the hyperglycemic patients, 31 individuals were classified as glucose intolerant and 29 as diabetic). Significant differences were found for glycaemia, LDL-c (Low Density Lipoprotein), and hs-CRP (high sensitivity C reactive protein) levels. Nevertheless it is possible to observe that patients with higher glycaemia showed increased values of Total Cholesterol, Triglycerides, LDL-c, Castelli Index I and II and estimative of LDL-c size particle and decreased HDL-c (High Density Lipoprotein) values. The comparison between hs-CRP levels and biochemical parameters shows significant differences for Body Mass Index, Triglycerides, HDL-c and the estimative of LDL-c particle. Also, the presence of Metabolic Syndrome is more prevalent in patients with high levels of hs-CRP. Diabetes patients have more significant increase in morbidity and mortality than the general population frequently due to further complications associated with the resistance to insulin. It is indispensable to outline the anthropometric and biochemical profile from hyperglycemic patients in order to work on secondary prevention of cardiovascular disease.

Investigating the effect of some fluoroquinolones on C-reactive protein levels and ACh-Induced blood pressure reduction deviations after aging of diabetes in STZ-Induced diabetic wistar rats

“…This protein has a common role with leptin in regulating fatty tissue mass and concentration of free fatty acids stored in it [34]. Induction of diabetes elevated CRP plasma levels, but this elevation was statically non-significant, while it was consistent with a previous study [35].…”

“…In this study, to evaluate the association of reduced endothelial dysfunction potential in diabetic wistars, which had been treated by fluoroquinolones, with reduced CRP plasma levels, the ratio of the increase in CRP in the four studied groups after the treatment with moxifloxacin, and levofloxacin, for sufficient time as antibiotics, according to the recommendations (14 days), was compared; CRP was re-evaluated after waiting for four months after post-treatment with fluoroquinolones; a comparison of CRP levels of non-diabetic group between the period pre-and post-fluoroqinolones treatment (i.e. a four-months interval) showed a statistically non-significant increase in CRP plasma levels, which is due to aging [37], while the increase in CRP plasma levels in the three diabetic groups within the same period was statistically significant; the increase in CRP plasma levels in the three diabetic groups was due to two factors: aging [37] and chronic hyperglycemia [35], plasma CRP levels in rats were less than 2 mg/L in all groups, which was consistent with some studies [38]. In addition, comparing the increased ratio among the four groups showed that there were a statistically significant increased ratio between diabetic groups and non-diabetic one, without a statistically significant difference among the three diabetic groups in CRP levels increasing ratio.…”

Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women

“…Our observations are consistent with in vitro studies carried out by Pasceri et al 29 , who point the direct involvement of CRP in the induction of adhesion molecules expression in human coronary artery endothelial cells. The study conducted by Barbalho et al 61 in the group of patients undergoing arteriography showed higher levels of lipids and CRP in patients with hyperglycemia compared to normoglycemic ones. It is believed that the accumulation of this protein in the subendothelial space depends both on its systemic concentration and local synthesis.…”