Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease

Chen, Ming-Chun; Wang, Ji‐Hung; Lee, Chung‐Jen; Hsu, Bang‐Gee

doi:10.2147/tcrm.s172231

Cited by 18 publications

(20 citation statements)

References 41 publications

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“…Результаты нашего исследования согласуются с данными многих авторов о наличии гендерных различий концентрации лептина сыворотки кровиу женщин этот показатель выше, чем у мужчин [5,19,22,30].…”

Section: Discussionunclassified

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Subcutaneous and Epicardial Adipose Tissue Leptin Gene Expression in Coronary Artery Disease Patient

Полякова

Колодина

Miroshnikova

et al. 2019

Transl. med. (Print)

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Objective. To assess the expression of the leptin gene (LEP) in the epicardial (EAT) and subcutaneous (SAT) adipose tissue in coronary artery disease (CAD) patients.Methods. 107 people were examined: 87 with CAD (57 men, 30 women), 20 without CAD (10 men, 10 women). Biopsy of EAT, SAT, coronary angiography, heart computed tomography, blood leptin levels were estimate, mRNA expression of the LEP gene evaluated by PCR.Results. In CAD patients with multivessel coronary artery lesion, the level of blood leptin is the highest. The expression of the LEP gene in EAT is higher in men than in women, in men with CAD higher than in non-coronary artery disease patients, and with a multivascular coronary lesion higher than in a 1–2 vascular lesion. Expression of the LEP gene in EAT in women with CAD is higher than with no CAD, and does not depend on the severity of coronary atherosclerosis. In SAT, LEP gene expression in men with CAD is higher than without CAD; women with CAD are lower than without CAD. Expression of the LEP gene in SAT is higher in men with a multivascular lesion than in 1–2 vascular lesion, and lower in women with a multivascular damage.Conclusions. The expression of the leptin gene in women is higher in SAT, and in men in EAT. Expression of the leptin gene in EAT with CAD is higher than without CAD. The expression of the leptin gene in SAT in men with CAD, especially with multivessel lesions, is higher than without coronary artery disease.

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Section: Discussionunclassified

“…Для пациентов с абдоминальным ожирением характерна гиперлептинемия [19]. Также установлена связь гиперлептинемии с артериальной гипертензией, дислипидемией и гипергликемией -факторами риска ИБС [21,22].…”

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Subcutaneous and Epicardial Adipose Tissue Leptin Gene Expression in Coronary Artery Disease Patient

Полякова

Колодина

Miroshnikova

et al. 2019

Transl. med. (Print)

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“…With patients wearing light clothing and no shoes, their body weight (BW) and height were measured to the nearest 0.50 kg and 0.50 cm, respectively. According to the Quetelet’s formula, body mass index (BMI) was calculated as the weight in kilograms divided by the height in meters squared [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Associations between High Serum Adipocyte Fatty Acid Binding Protein and First Hospitalization in Kidney Transplantation Patients: A 5-Year Follow-up Study

Lee

Chen

et al. 2020

IJERPH

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Adipocyte fatty acid binding protein (A-FABP) is predictive of type 2 diabetes mellitus incidences and metabolic syndrome and is independently associated with atherosclerosis. The present study aimed to assess the association between serum A-FABP levels and future first hospitalization events in kidney transplantation (KT). We enrolled 72 KT patients from January through April 2012 and followed up on these subjects until June 2017. The first hospitalization events incidence was the primary endpoint. Using a commercially available enzyme immunoassay, serum A-FABP levels were measured from the patient’s fasting blood samples. During a median 65-month follow-up, 49 first hospitalization events occurred. KT patients with first hospitalization events had greater incidences of hypertension, diabetes, and higher serum blood urea nitrogen, creatinine, triglyceride, and A-FABP levels than those without the events. Kaplan–Meier analysis showed that the cumulative incidence of first hospitalization events was greater in the high A-FABP group than in the low A-FABP group. Multivariate Cox analysis with significant variables showed that serum A-FABP (hazard ratio = 1.012; 95% confidence interval = 1.000–1.025; p = 0.044) was independently associated with first hospitalization events among KT patients. The results revealed that serum A-FABP is associated with first hospitalization events in KT patients. However, further prospective studies are needed to determine the mechanisms underlying this association.

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“…Investigators believe that a high level of leptin is related to low arterial extensibility and participates in the pathogenesis of atherosclerosis via mechanisms different from vascular relaxation. Some authors have noted a connection between serum concentrations of leptin and various cardiovascular risks, including stroke, chronic heart failure, acute myocardial infarction, coronary artery disease, and left ventricle hypertrophy [30][31][32][33][34]. It seems worthwhile to study leptin/adiponectin ratios.…”

Section: Leptinmentioning

confidence: 99%

The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review

et al. 2020

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Adipose tissue is considered one of the endocrine organs in the body because of its ability to synthesize and release a large number of hormones, cytokines, and growth and vasoactive factors that influence a variety of physiological and pathophysiological processes, such as vascular tone, inflammation, vascular smooth muscle cell migration, endothelial function, and vascular redox state. Moreover, genetic factors substantially contribute to the risk of obesity. Research into the biochemical effects of molecules secreted by visceral adipocytes as well as their molecular genetic characteristics is actively conducted around the world mostly in relation to pathologies of the cardiovascular system, metabolic syndrome, and diabetes mellitus. Adipokines could be developed into biomarkers for diagnosis, prognosis, and therapeutic targets in different diseases. This review describes the relevance of secretory activity molecules of visceral adipocytes in cardiovascular disease associated abdominal obesity.

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Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease

Cited by 18 publications

References 41 publications

Subcutaneous and Epicardial Adipose Tissue Leptin Gene Expression in Coronary Artery Disease Patient

Subcutaneous and Epicardial Adipose Tissue Leptin Gene Expression in Coronary Artery Disease Patient

Associations between High Serum Adipocyte Fatty Acid Binding Protein and First Hospitalization in Kidney Transplantation Patients: A 5-Year Follow-up Study

The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review

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