Association between ACE A240T polymorphism and cancer risk: a meta-analysis

Abstract

Objectives The relationship between the A240T polymorphism in the angiotensin-converting enzyme ( ACE) gene and cancer risk remains controversial. Therefore, we conducted a meta-analysis of relevant studies from the published literature. Methods We comprehensively searched available databases to identify eligible studies on the relationship of ACE A240T polymorphism with cancer risk. We calculated pooled odds ratios (OR) with 95% confidence intervals (CI) and then evaluated heterogeneity and publication bias. Results Eight case-control studies were identified from five articles. Results showed that the ACE A240T polymorphism was related to cancer risk (AT vs AA: OR 2.14, 95% CI: 1.51–3.04; TT vs AA: OR 1.07, 95% CI: 0.90–1.27; recessive model: OR 0.48, 95% CI: 0.31–0.77; dominant model: OR 2.13, 95% CI: 1.54–2.97). The same conclusion was made for subgroup analysis by race or cancer type. In the subgroup analysis by quality score assessment, the ACE A240T polymorphism contributed to cancer risk in high-quality studies but not in low-quality studies. Conclusion The A240T polymorphism in the ACE gene might be related to the risk of cancer. Nevertheless, large-scale studies should be performed to obtain convincing evidence on the roles of ACE A240T polymorphism on cancer risk.

SLC6A4 gene L/S polymorphism and susceptibility to pulmonary arterial hypertension: a meta-analysis

“…However, after removing articles deviating from HWE, the heterogeneity was removed for stratification analysis, suggesting that studies deviating from HWE were a significant source of the heterogeneity. 19 This current meta-analysis had several limitations. First, only articles published in English-language journals were included, with unpublished or non-English-language Table 3.…”

“…However, after removing articles deviating from HWE, the heterogeneity was removed for stratification analysis, suggesting that studies deviating from HWE were a significant source of the heterogeneity. 19 …”

Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection

“…The D allele might affect renin-angiotensin pathway activity by increasing the serum or local level of ACE, leading to damage of the vascular endothelium and lung epithelium [23]. Studies have shown that some ACE polymorphisms are associated with Alzheimer's disease (the II and ID ACE genotypes), cardiovascular disease (DD), hepatitis C virus (HCV) infection (DD), and cancers (ACE A240T polymorphism) [24][25][26][27][28][29] (Table 1). Itoyama et al found that the frequency of the D allele in SARS patients (with and without hypoxemia) was significantly higher than in healthy controls [21].…”

Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk

“…Some single nucleotide polymorphisms (SNPs) in cancer-related genes have been found to affect cancer risk. 1 – 3 …”

“…Some single nucleotide polymorphisms (SNPs) in cancer-related genes have been found to affect cancer risk. [1][2][3] The metallothionein 2A (MT2A) gene located at chromosome 16q13 is a member of the metallothionein gene family. 4 The protein encoded by MT2A can interact with that encoded by the homeobox containing 1 gene (HMBOX1) in vascular endothelial cells, controlling intracellular zinc levels and affecting apoptotic and autophagy pathways.…”