Association between<i>CD14</i>gene promoter polymorphisms with serum total-IgE and eosinophil levels in atopic and non-atopic asthma patients in a Chinese Han population

Feng, Jiankai; Zhang, Caiji; Wang, Zongguo; Li, Qian; Li, Jie; Wang, Hongling

doi:10.3109/02770903.2015.1080267

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The findings of this case–control study among 324 American Indian children in the Northern Plains of the United States are largely in accord with previous evidence of increased biomarkers of inflammation and specific, immune sensitization. We demonstrated increased total IgE immunoglobulins among those with asthma (although not in a multivariate model including a measure of specific sensitization), as also reported in studies of European [ 12 , 23 – 25 ], Han Chinese [ 26 ], African Americans and various Hispanic populations [ 11 , 27 ]. Other studies have been unable to find an association between total IgE and asthma [ 28 ] or found this association holds only among those with atopic sensitization to specific antigens [ 29 ].…”

Section: Discussionsupporting

confidence: 86%

Humoral immune factors and asthma among American Indian children: a case–control study

et al. 2016

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BackgroundAsthma is recognized as intimately related to immunologic factors and inflammation, although there are likely multiple phenotypes and pathophysiologic pathways. Biomarkers of inflammation may shed light on causal factors and have potential clinical utility. Individual and population genetic factors are correlated with risk for asthma and improved understanding of these contributions could improve treatment and prevention of this serious condition.MethodsA population-based sample of 108 children with clinically defined asthma and 216 control children were recruited from a small community in the northern plains of the United States. A complete blood count, high sensitivity C-reactive protein, total IgE and specific antibodies to 5 common airborne antigens (CAA), in addition to basic demographic and anthropomorphic data were obtained. Logistic regression was primarily used to determine the association between these humoral factors and risk of asthma.ResultsThe body mass index (BMI) of those with asthma and their total leukocyte counts, percentage of eosinophils, and levels of total IgE were all greater than corresponding control values in univariate analysis. The presence of detectable, specific IgE antibodies to five common airborne antigens was more likely among cases compared with controls. In multivariate analysis, total IgE was independently associated with asthma; but not after inclusion of a cumulative measure of specific IgE sensitization.ConclusionMany previously reported associations between anthropomorphic and immune factors and increased risk of asthma appear to be also present in this American Indian population. In this community, asthma is strongly associated with sensitization to CAA.

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Section: Discussionsupporting

confidence: 86%

Humoral immune factors and asthma among American Indian children: a case–control study

et al. 2016

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“…There were 210 DEGs in ciliated cells in the WT-HDM vs. WT-Sal comparison (Figures 3A and 4C,D and Tables S5 and S6). Some DEGs from this comparison, such as Fos [37], Jun [38], Hes1 [39], Cd14 [40], and C3 [31], have been associated with asthma pathogenesis. Subsequently, we identified 96 significantly enriched pathways in these DEGs (Table S8).…”

Section: Exposure To Hdm Led To Cell Type-specific Changes In the Epc...mentioning

confidence: 97%

Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1

Zhu

Brown

Cai

et al. 2022

Genes

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Tet1 protects against house dust mite (HDM)-induced lung inflammation in mice and alters the lung methylome and transcriptome. In order to explore the role of Tet1 in individual lung epithelial cell types in HDM-induced inflammation, we established a model of HDM-induced lung inflammation in Tet1 knockout and littermate wild-type mice, then studied EpCAM+ lung epithelial cells using single-cell RNA-seq analysis. We identified eight EpCAM+ lung epithelial cell types, among which AT2 cells were the most abundant. HDM challenge altered the relative abundance of epithelial cell types and resulted in cell type-specific transcriptomic changes. Bulk and cell type-specific analysis also showed that loss of Tet1 led to the altered expression of genes linked to augmented HDM-induced lung inflammation, including alarms, detoxification enzymes, oxidative stress response genes, and tissue repair genes. The transcriptomic regulation was accompanied by alterations in TF activities. Trajectory analysis supports that HDM may enhance the differentiation of AP and BAS cells into AT2 cells, independent of Tet1. Collectively, our data showed that lung epithelial cells had common and unique transcriptomic signatures of allergic lung inflammation. Tet1 deletion altered transcriptomic networks in various lung epithelial cells, which may promote allergen-induced lung inflammation.

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“… 22 Another study in a Chinese population has shown that the frequency of CD14 rs2569191 A-allele in allergic asthma is significantly lower than that in non-allergic asthma. 39 Moreover, we believe that although AR and asthma share many similarities, the inhibitory effects of genetic variations in TLR pathway on AR, asthma or other allergic diseases may differ to some extent, as Micheal et al 28 confirmed that in Pakistani adults, the CD14 rs2569191 is significantly associated with atopic asthma, but not AR.…”

Section: Discussionmentioning

confidence: 84%

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Chen¹,

Dai²,

Zhang³

et al. 2022

JIR

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Background Allergic rhinitis (AR) is a nasal inflammatory disease resulting from a complex interplay between genetic and environmental factors. The association between Toll-like receptor (TLR) signaling pathway and environmental factors in AR pathogenesis remains to be explored. This study aims to assess the genetic association of AR with single nucleotide polymorphisms (SNPs) in TLR signaling pathway, and investigate the roles of gene–gene and gene–environment interactions in AR. Methods A total of 452 AR patients and 495 healthy controls from eastern China were enrolled in this hospital-based case–control study. We evaluated putatively functional genetic polymorphisms in TLR2, TLR4 and CD14 genes for their association with susceptibility to AR and related clinical phenotypes. Interactions between environmental factors (such as traffic pollution, residence, pet keeping) and polymorphisms with AR were examined using logistic regression. Models were stratified by genotype and interaction terms, and tested for the significance of gene–gene and gene–environment interactions. Results In the single-locus analysis, two SNPs in CD14 , rs2563298 (A/C) and rs2569191 (C/T) were associated with a significantly decreased risk of AR. Compared with the GG genotype, the GT and GT/TT genotypes of TLR2 rs7656411 (G/T) were associated with a significantly increased risk of AR. Gene–gene interactions (eg, TLR2 rs7656411, TLR4 rs1927914, and CD14 rs2563298) was associated with AR. Gene–environment interactions (eg, TLR4 or CD14 polymorphisms and certain environmental exposures) were found in AR cases, but they were not significant after Bonferroni correction. Conclusion The genetic polymorphisms of TLR2 and CD14 and gene–gene interactions in TLR signaling pathway were associated with susceptibility to AR in this Han Chinese population. However, the present results were limited to support the association between gene–environment interactions and AR.

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Association betweenCD14gene promoter polymorphisms with serum total-IgE and eosinophil levels in atopic and non-atopic asthma patients in a Chinese Han population

Abstract: There was a statistical association between the serum total-IgE level and the CD14 gene promoter SNPs in the non-atopic asthma group. The eosinophil level was not found to be statistically associated with the CD14 gene promoter SNPs in either the atopic asthma or non-atopic asthma groups.

Cited by 6 publications

References 20 publications

Humoral immune factors and asthma among American Indian children: a case–control study

Humoral immune factors and asthma among American Indian children: a case–control study

Single-Cell RNA-Seq Analysis Reveals Lung Epithelial Cell Type-Specific Responses to HDM and Regulation by Tet1

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

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