Association betweenHelicobacter pyloriand mortality in the NHANES III study

Chen, Yu; Segers, Stephanie; Blaser, Martin J.

doi:10.1136/gutjnl-2012-303018

Cited by 96 publications

(91 citation statements)

References 59 publications

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“…The positive association of H. pylori infection with CVD was first reported in a case-control study 4) in which individuals with H. pylori seropositivity had an increased risk, approximately two-fold, of developing CVD. However, not all subsequent studies have supported these results [5][6][7][8][9][10][11][12][13] . For example, a 1998 meta-analysis of 18 studies found no significant association between H. pylori and risk of coronary heart disease (CHD), a major component of CVD 14) .…”

Section: Introductionmentioning

confidence: 70%

“…The majority of previous research on the above association was conducted in Western countries [5][6][7][8][9][10][11][12][13] and findings have been inconsistent and inconclusive. It is possible, however, that variations in the study tion to H. pylori seropositivity.…”

Section: Discussionmentioning

confidence: 99%

“…Characteristics between cases and controls were compared using the Mann -Whitney tests for continuous variables and chi-square tests for discrete variables. Conditional logistic regression models were used to estimate crude and multivariable-adjusted odds ratios (OR) and 95% confidence intervals (CI) for CHD or stroke death in relation between these outcome measures 12,13) . Although the role of H. pylori in the pathogenesis of CVD remains controversial, the proposed mechanism of action, i.e., the changes in inflammatory markers in H. pylori positive individuals may be associated with increased risk of CVD, persists 15) .…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter Pylori Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Lin

Obata

Kikuchi

et al. 2015

J Atheroscler Thromb

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Aim: An increasing number of studies have linked Helicobacter pylori (H. pylori) infection to extragastric diseases; however, the role of H. pylori in the pathogenesis of cardiovascular disease (CVD) remains controversial. We examined the association between H. pylori infection and risk of death from coronary heart disease (CHD) and stroke in a nested case-control study within a large prospective cohort study of Japanese subjects. Methods: The cases were 627 subjects who died from CHD and stroke during the follow-up period until December 31, 2003, and 627 control subjects were selected and matched to cases on sex, age, and area. Commercial immunoassay IgG enzyme-linked immunosorbent assay kits were used for the determination of the seropositivity for H. pylori. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model. Conclusion:The results of this nested case-control study suggest that there is no association between H. pylori infection and CHD and stroke mortality risk in otherwise healthy, elderly Japanese individuals.

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Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Helicobacter Pylori Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Lin

Obata

Kikuchi

et al. 2015

J Atheroscler Thromb

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“…From the initial observations and molecular biology studies, it would seem to indicate that H. pylori is a dreaded noxious pathogen. However, a number of studies, notably epidemiological ones, have also indicated inverse correlations, odds ratios significantly less than one, for a number of serious health problems, in persons harboring cagA+ strains [39]. Further studies in selected populations may help to shed light on these Table 2.…”

Section: H Pylori Colonization Vs Infectionmentioning

confidence: 99%

“…This suggests that H. pylori cagA+ is an important director, perhaps playing a keystone species role in the stomach of many persons. Given the rising appreciation of the importance of the microbiota in determining health and disease, H. pylori may thus represent a key to understanding the multidimensional activities that go on at the humanbacterial interface [33][34][35][36][37][38][39][40][41][42]. For this reason, H. pylori presents a number of important opportunities toward gaining better insight into both bacterial and host biology and interactions.…”

Section: H Pylori Colonization Vs Infectionmentioning

confidence: 99%

Helicobacter pylori: enemy, commensal or, sometimes, friend?

Whalen¹,

Massidda²

2015

J Infect Dev Ctries

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Helicobacter pylori is a Gram-negative ε-proteobacterium that colonizes about 50% of humans. Some pertinent characteristics are that it can survive the acid of the stomach, produces urease to neutralize it and is motile due to apical flagella. Not surprisingly given its wide distribution, it has long colonized mankind and its genome encodes many features that allows this. Consequently, it frequently has a persistent lifelong association with humans and, differently from most pathogens that are transmitted horizontally, it is preferentially transmitted vertically, often from mother to child. A variety of genes and polymorphisms, both in H pylori and in humans, mediate the complex host-bacterium relationship, and can also determine if and what pathologies will be triggered by the species. H. pylori is naturally transformable, very recombinogenic and has a high mutation rate. Microbiota studies of the stomach have shown it to be an important species with a potentially regulatory role for the gastric microbial community. Likewise, epidemiological work has suggested that, while it clearly increases the risk of peptic ulcers and gastric cancer in some populations, it is also associated with lower risk of esophageal cancer and several other important pathologies. More recently, antibacterial resistant strains have been isolated, posing a problem for public health officials who called for its eradication. Hence, study of H. pylori and how it interacts with us can help revealing mutualistic or pathogenic interactions and the immune response in the digestive niche.

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Eradication of Helicobacter pylori for non-ulcer dyspepsia

Martin

Soo²,

Deeks³

et al. 2011

Cochrane Database of Systematic Reviews

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In the article published recently in the Gut, many experts in the H. pylori infection were gathered in Kyoto and agreed to a statement on eradication of H. pylori. 1 The experts concluded that H. pylori infection should be considered as an infectious disease, like tuberculosis and syphilis, and has to be eradicated in all individuals. This recommendation to deal with H. pylori infection H. pylori infection is almost universal in the adult population, but also in countries with a low infection rate.Tuberculosis is beside of its high economic burden for society and the long duration of its treatment, is not a symptomless disease and comparable to the long life silent H. pylori infection disease: in 33 studies, the death rate of tuberculosis ranges between 1.8% to 33.3% during the time period of active treatment of patients. 2 Fetal death occurring in gravid women with asymptomatic syphilis infection in the general population of South America and Africa, where a high prevalence of H. pylori infection exists, is a serious problem. 3,4 However, H. pylori infection in a large population study in USA, except for gastric cancer, was not responsible for all-cause mortality. 5 Regarding the eradication of each patient with H. pylori positive dyspepsia, our experiences in Iran were negative: 110 patients with H. pylori positive dyspepsia not responding to previous 4 weeks treatment with antacid were randomized to eradication or symptomatic treatment, the complete or moderate response to treatment after 9 months was the same in both groups. 6 In another recent publication from Iran, with 359 H. pylori positive dyspepsia, the eradication therapy compared with the placebo group was not successful after one year follow-up. 7 The experiences obtained in other countries were not impressive H. pylori eradication was small; only one out of 14 subjects with non-ulcer dyspepsia had long term responses by a meta-analysis. 8 A better response of eradication therapy in nonulcer dyspepsia was achieved in China. 9,10 As the cause of nonulcer dyspepsia is heterogeneous, then the effect of eradication therapy must be proven in each country. It should be considered that the prevalence of ulcer-like dyspepsia as probable precursor of peptic ulcer disease might be different in various countries.From the other hand, eradication of H. pylori in the population with no risk for peptic ulcer disease or gastric cancer could be associated with some inadequate consequences, which overweights in patients with duodenal ulcer within 3 years after H. pylori eradication, compared with those not eradicated. 11 In spite of 12 In a meta-analysis with 43 case-control studies and a few 13 The risk of occurrence of esophagitis after H. pylori eradication was greater in Asian than in European countries.Furthermore, there is now adequate evidence about the inverse association of H. pylori infection with Barrett Esophagus, 14

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Association betweenHelicobacter pyloriand mortality in the NHANES III study

Cited by 96 publications

References 59 publications

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Helicobacter pylori: enemy, commensal or, sometimes, friend?

Eradication of Helicobacter pylori for non-ulcer dyspepsia

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