Association between Helicobacter pylori infection and acute inflammatory demyelinating polyradiculoneuropathy

Abstract

The aim of this study was to investigate a possible association between Helicobacter pylori infection and acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Of 17 consecutive patients with Guillain-Barre syndrome (GBS), 13 patients (six females; mean age 50 +/- 24 years) with AIDP were investigated. Clinical status was evaluated according to Hughes' score, and electrophysiological tests were performed within 2 weeks from disease onset. Helicobacter pylori infection was detected histologically and serum H. pylori-specific IgG antibodies were analysed by ELISA. Twenty asymptomatic patients (12 females; mean age 63 +/- 8 years), undergoing upper gastrointestinal endoscopy for investigation of mild iron deficiency anaemia, served as controls. Helicobacter pylori was found in 12 of 13 AIDP patients (92%), and in 10 of 20 controls (50%), (P = 0.02). Electrophysiological studies showed demyelination in all AIDP patients. High levels of anti-H. pylori IgG antibodies correlated with advanced clinical status. Five of seven AIDP patients with high levels of anti-H. pylori IgG antibodies had delayed F-wave latencies, indicating affection of proximal segments of peripheral nerves. Helicobacter pylori infection seems to be more frequent in AIDP patients. Anti-H. pylori titre might reflect advanced clinical status. Anti-H. pylori IgG antibodies are also associated with involvement of the proximal parts of peripheral nerves in AIDP.

A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis

“…Moreover, as in the case of AIP, H. pylori is associated with autoimmune conditions like SjS (i.e., autoimmune sialadenitis), PBC, PSC, AIH or hepatitis C virus (HCV)-related liver disease which trigger autoimmune sequelae (AIH and HCV-related SjS) [25][26][27][28][29][30][31][32][33][34][35]. These H. pylori-related diseases are also characterized by fibrotic changes and/or lymphoplasmacytic inflammations [28,[35][36][37][38][39], accompanied by aberrations of T cell apoptosis that contribute to hepatobiliary-or extrahepatic-tissue destruction [35,36,[40][41][42][43][44][45][46].…”

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

“…Hp detection methods were reported previously [2,8]. Serum anti- Hp IgG antibody titers were assessed by the enzyme-linked immunosorbent assay (ELISA) method in all patients and healthy individuals.…”

Letter to the Editor: Cervical decompression

“…8 Elevated anti-H. pylori immunoglobulin antibodies were associated with the severity of clinical symptoms and involved in the proximal parts of peripheral nerves in AIDP. 8 Nevertheless, without further studies, this correlation cannot be directly applied to diagnose AMSAN.…”

“…Of note is a correlation between H. pylori infections and acute inflammatory demyelinating polyradiculoneuropathy (AIDP), the most common subtype of GBS. 8 According to the report by Kountouras and colleagues, infection with H. pylori has been found in 92% of AIDP patients, which is more frequent than in healthy controls. 8 Elevated anti-H. pylori immunoglobulin antibodies were associated with the severity of clinical symptoms and involved in the proximal parts of peripheral nerves in AIDP.…”

“…8 According to the report by Kountouras and colleagues, infection with H. pylori has been found in 92% of AIDP patients, which is more frequent than in healthy controls. 8 Elevated anti-H. pylori immunoglobulin antibodies were associated with the severity of clinical symptoms and involved in the proximal parts of peripheral nerves in AIDP. 8 Nevertheless, without further studies, this correlation cannot be directly applied to diagnose AMSAN.…”