Association between <i>HLA-DRB1</i>* allele polymorphism and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region

Wang, Liping; Li, Boqi; Tie, Xiaomin; Liu, Tao

doi:10.1177/0300060519893852

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…This difference can be attributed to the difference in age group, as this study was conducted among children, in addition to the difference in race studied [ 28 ]. Moreover, the results of this study differed from Wang et al study found that HLA-DRB1*13 allele frequency was significantly higher in patients with caries while HLA-DRB1*09 allele was significantly lower in patients with caries than in healthy controls [ 29 ]. This difference can be attributed to the difference in the studied community.…”

Section: Discussioncontrasting

confidence: 96%

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

Malas,

Kochaji,

Soukkarieh

et al. 2024

Cureus

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Background and objectives Numerous studies have shown that there is evidence that genetic factors contribute in different ways to the occurrence of caries lesions, and the multiple differences in the human leucocytes antigen (HLA) gene patterns play an important role in the body's immune response. Therefore, this study aimed to evaluate the association between some HLA class II alleles (HLA-DR4, HLA-DQ2, HLA-DQ4) and early childhood caries (ECC) occurrence in Syrian children. Materials and methods The study included 80 children aged three to six, divided into two groups: Group 1 (n = 40) being severe early childhood caries (S-ECC) children (deft ≥ 10) and Group 2 (n = 40) being free caries children (deft = 0). The genomic DNAs were extracted and collected by taking a buccal swab using a sterile metal strip and were amplified by polymerase chain reaction-single specific primer (PCR-SSP) and then HLA-typing was performed for all alleles. Results There were no statistically significant differences in the frequency of occurrence of S-ECC, HLA-DR4, and HLA-DQ2 alleles (p = 0.626, 0.256 respectively), while the incidence of S-ECC was associated with the DQ4 allele (p = 0.012). Conclusion HLA class II molecules may play a crucial role in predisposing to ECC, since positive HLA-DQ4 may enhance the chance of developing ECC. However, no association were found between (HLA-DR4 and HLA-DQ2) and ECC.

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Section: Discussioncontrasting

confidence: 96%

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

Malas,

Kochaji,

Soukkarieh

et al. 2024

Cureus

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In Silico Analysis: HLA-DRB1 Gene’s Variants and Their Clinical Impact

et al. 2023

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The HLA-DRB1 gene encodes a protein that is essential for the immune system. This gene is important in organ transplant rejection and acceptance, as well as multiple sclerosis, systemic lupus erythematosus, Addison’s disease, rheumatoid arthritis, caries susceptibility, and Aspirin-exacerbated respiratory disease. The following Homo sapiens variants were investigated: single-nucleotide variants (SNVs), multi-nucleotide variants (MNVs), and small insertions–deletions (Indels) in the HLA-DRB1 gene via coding and untranslated regions. The current study sought to identify functional variants that could affect gene expression and protein product function/structure. ALL target variants available until April 14, 2022, were obtained from the Single Nucleotide Polymorphism database (dbSNP). Out of all the variants in the coding region, 91 nsSNVs were considered highly deleterious by seven prediction tools and instability index; 25 of them are evolutionary conserved and located in domain regions. Furthermore, 31 indels were predicted as harmful, potentially affecting a few amino acids or even the entire protein. Last, within the coding sequence (CDS), 23 stop-gain variants (SNVs/indels) were predicted as high impact. High impact refers to the assumption that the variant will have a significant (disruptive) effect on the protein, likely leading to protein truncation or loss of function. For untranslated regions, functional 55 single-nucleotide polymorphisms (SNPs), and 16 indels located within microRNA binding sites, furthermore, 10 functionally verified SNPs were predicted at transcription factor-binding sites. The findings demonstrate that employing in silico methods in biomedical research is extremely successful and has a major influence on the capacity to identify the source of genetic variation in diverse disorders. In conclusion, these previously functional identified variants could lead to gene alteration, which may directly or indirectly contribute to the occurrence of many diseases. The study’s results could be an important guide in the research of potential diagnostic and therapeutic interventions that require experimental mutational validation and large-scale clinical trials.

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Association between *HLA-DRB1** allele polymorphism and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region

Cited by 2 publications

References 18 publications

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

In Silico Analysis: HLA-DRB1 Gene’s Variants and Their Clinical Impact

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Association between HLA-DRB1* allele polymorphism and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region

Cited by 2 publications

References 18 publications

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children

In Silico Analysis: HLA-DRB1 Gene’s Variants and Their Clinical Impact

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Association between *HLA-DRB1** allele polymorphism and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region