Association between <i>Toxoplasma gondii</i> infection and history of blood transfusion: a case-control seroprevalence study

Alvarado‐Esquivel, Cosme; Sánchez‐Anguiano, Luis Francisco; Hernández‐Tinoco, Jesús; Ramos-Nevárez, Agar; Estrada-Martínez, Sergio; Cerrillo-Soto, Sandra Margarita; Medina-Heredia, Gonzalo Elías; Guido-Arreola, Carlos Alberto; Soto-Quintero, Araceli Alejandra; Beristaín-Garcia, Isabel

doi:10.1177/0300060518757928

Cited by 27 publications

(20 citation statements)

References 35 publications

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“…Previous studies demonstrated that blood transfusion was a risk factor for T. gondii infection in patients with malignancy [6,15,21]. In the current study, we found among many clinical variables, the seroprevalence of T. gondii was only associated with the history of chemotherapy.…”

supporting

confidence: 52%

Toxoplasma gondii infection in children with lymphoma in Eastern China: seroprevalence, risk factors and case–control studies

et al. 2019

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Epidemiological data for Toxoplasma gondii regarding malignancy have gained increasing attention; however, the information about T. gondii infection among children with malignant lymphoma (ML) in China is unclear. Therefore, 314 children with lymphoma and 314 healthy children, age- and gender-matched, were recruited to estimate the seroprevalence of T. gondii in the participants and identify the risk factors of infection. Blood samples from all participants were collected and examined for T. gondii IgG and IgM antibodies using ELISA. The results showed that the overall seroprevalence of T. gondii antibodies (including IgG and/or IgM) in ML patients and healthy controls was 19.8% and 9.9%, respectively. Contact with the cats, consumption of oysters and history of chemotherapy were estimated to be the risk factors for T. gondii infection in children with lymphoma by multivariable logistic regression analysis, whereas in healthy children, contact with cats and consumption of oysters were the risk factors. Moreover, among various histological types of lymphoma, individuals with NK/T-cell lymphoma, B-small lymphocytic lymphoma, marginal zone B-lymphoma and Hodgkin's lymphoma had a higher seroprevalence than healthy controls (P < 0.05). These findings indicated the high prevalence of T. gondii infection in children with lymphoma, and hence, efforts should be performed to evaluate the effect of the infection further in lymphoma patients.

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confidence: 52%

Toxoplasma gondii infection in children with lymphoma in Eastern China: seroprevalence, risk factors and case–control studies

et al. 2019

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“…It is well documented that blood transfusion could be a potential risk factor for T. gondii infection. (59) Meanwhile, blood can be transfused frequently to pregnant women, posing those seronegative to the risk of contracting primary infections.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii Infection in Relation to Pregnancy Characteristics and Bad Obstetric History among Pregnant Women Seeking Healthcare in Sana’a City, Yemen

Abdul‐Ghani

Al-Nahari²,

Yousef³

et al. 2019

YJMS

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Objective: To determine the seroprevalence and risk factors associated with Toxoplasma gondii among pregnant women seeking healthcare in Sana'a city in relation to pregnancy characteristics and bad obstetric history (BOH). Methods: This hospital-based, cross-sectional study was conducted among 379 pregnant women seeking healthcare in Sana'a city. Data on socioeconomic and pregnancy characteristics, BOH and possible risk factors associated with T. gondii infection were collected using a structured, pre-designed questionnaire. Anti-Toxoplasma IgG and IgM antibodies were detected using OnSite TM Combo tests. Data were analyzed using the IBM SPSS Statistics using appropriate statistical tests, and a bivariate logistic regression model was used to determine the risk factors possibly associated with T. gondii infection among pregnant women. Differences or associations between categorical variables were considered statistically significant at P values <0.05. Results: T. gondii infection was seroprevalent among 18.7% of pregnant women seeking healthcare in Sana'a. Educational status and household size were the sociodemographic factors significantly associated with anti-Toxoplasma IgG seropositivity. Illiterate women were at fourfold higher risk of infection compared to those with higher education (OR = 4.0, 95% CI: 1.69-9.25; P = 0.002). Although those with school education were twice more likely to be infected with T. gondii compared to those with higher education, the association was on the borderline (OR = 2.0, 95% CI: 0.98-4.06; P = 0.055). On the other hand, pregnant women living in households of ≥5 members were 1.7 times more likely to be infected (OR = 1.7, 95% CI: 1.03-2.95; P = 0.026). Regarding the BOH among pregnant women, past exposure to infection was significantly associated with premature delivery (P = 0.004) and history of fetal deaths (P = 0.004). Drinking unboiled water (OR = 2.1, 95% CI = 0.55-8.07; P = 0.192) and frequent blood transfusion (OR = 1.8, 95% CI = 0.50-6.1; P = 0.288) increased the odds of exposure of pregnant women to infection, but the associations were not statistically significant. On the other hand, other studied factors were not significantly associated with past exposure to infection. Conclusions: The majority (>80.0%) of pregnant women seeking healthcare in Sana'a city are non-immune to primary infection with T. gondii during pregnancy as evidenced by their seronegative status, where only 18.7% of them were seropositive for anti-Toxoplasma IgG. Higher infection rates were significantly associated with being illiterate and living within households of ≥5 members. With respect to self-reported BOH, T. gondii infection was significantly associated with premature delivery and history of fetal deaths. Drinking unboiled water and frequent blood transfusions increased the odds of exposure of pregnant women to infection, though not reaching statistical significance. Further large-scale community-based studies are recommended to determine the risk factors associated with pregnancy characteri...

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“…After infection, T. gondii can disseminate into each organ of the infected host through blood circulation [32]. Previous studies have shown that intracellular tachyzoites can disseminate into the whole body through the blood circulation, while extracellular tachyzoites do not have this ability [33, 34]. In this study, oral cancer patients with blood transfusion history had a significantly higher seroprevalence than control subjects (adjusted OR = 1.66, 95% CI: 1.18–2.32, P = 0.003).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study

Zhou

Zhang

et al. 2018

Epidemiol. Infect.

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Over the recent years, potential associations between Toxoplasma gondii (T. gondii) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between T. gondii infection and oral cancer remains relatively unexplored. We performed a case-control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to T. gondii by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (P < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to T. gondii, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to T. gondii. In addition, multiple logistic analysis showed that T. gondii infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between T. gondii infection and oral cancer patients. However, further studies are necessary to elucidate the role of T. gondii in oral cancer patients.

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Association between Toxoplasma gondii infection and history of blood transfusion: a case-control seroprevalence study

Cited by 27 publications

References 35 publications

Toxoplasma gondii infection in children with lymphoma in Eastern China: seroprevalence, risk factors and case–control studies

Toxoplasma gondii infection in children with lymphoma in Eastern China: seroprevalence, risk factors and case–control studies

Toxoplasma gondii Infection in Relation to Pregnancy Characteristics and Bad Obstetric History among Pregnant Women Seeking Healthcare in Sana’a City, Yemen

Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study

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