Association between TP73 G4C14-A4T14 polymorphism and different cancer types: an updated meta-analysis of 55 case–control studies

Abstract

Objective The TP73 G4C14-A4T14 variant has been associated with elevated cancer risk, but the evidence is inconclusive. We performed a meta-analysis to clarify the role of this variant in cancer development. Methods Eligible literature was selected by searching PubMed, Google Scholar, Cochrane Library, and Embase. The meta-analysis was performed using Review Manager 5.4. Results A meta-analysis of 55 case–control studies showed that the G4C14-A4T14 variant was significantly associated with overall cancer development in five genetic models, including the allele model (AM), codominant model 1 (COD1), COD2, dominant model (DM), and over-dominant model (OD). Sub-group analysis based on ethnicity showed significantly higher risks in Africans in COD2 and RM and in Whites in AM, COD2, DM, and recessive model (RM). Cancer-specific subgroup analysis identified significant risks of gynecological (ovarian, cervical, and endometrial cancer), colorectal, oral, head and neck, and other cancers. Moreover, hospital-based controls revealed significant cancer risks in the AM, COD1, COD2, DM, and RM genetic models. Our findings were confirmed by trial sequential analysis. Conclusion This meta-analysis confirmed that TP73 G4C14-A4T14 significantly elevates the overall cancer risk, especially in White, African, and hospital-based populations, and specifically predisposes individuals to gynecological, colorectal, oral, and head and neck cancers. This meta-analysis was registered at INPLASY (registration number: INPLASY202210070).

Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis

“…Jafrin et al, in a meta-analysis based 55 case-control studies including eight studies on cervical cancer examined the role of TP73 G4C14-A4T14 polymorphism with development of different cancers. Their pooled data revealed that this variant significantly associated with increased risk of cancer, especially in Caucasian and African populations, and specifically predisposes individuals to gynecological, colorectal, oral, and head and neck cancers [ 27 ]. In 2018, Meng et al, in a published pooled data based on 36 case-control studies with 9493 cancer cases and 13,157 controls (6 studies on cervical cancer) evaluated the association of TP73 G4C14-A4T14 polymorphism with susceptibility to different cancer.…”

“…Tumor Protein TP73 ( TP73 ) is an essential member of a gene family that comprises TP63 (p63) and the well-characterized tumor suppressor TP53 (p53) [ 26 - 28 ]. TP73 is plays important roles in embryonic development and differentiation, and located on chromosome 1p36-33, mapping on a region often deleted in different cancers [ 25 , 27 ]. two single polymorphisms G4A (rs2273953) and C14T (rs1801173) in the 5′-UTR of exon 2 of the TP73 gene is reported.…”