Association between <i>trans</i> fatty acid intake and overweight including obesity in 4 to 5‐year‐old children from the INMA study

Scholz, Alexander; Navarrete-Muñoz, Eva María; García‐de‐la‐Hera, Manuela; Fernández-Somoano, Ana; Tardón, Adonina; Santa‐Marina, Loreto; Pereda‐Pereda, Eva; Romaguera, Dora; Guxens, Mònica; Beneito, Andrea; Íñiguez, Carmen; Vioque, Jesús

doi:10.1111/ijpo.12528

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…In the Spanish INMA (INfancia y Medio Ambiente) study similar results were found in 4-to 5-year-old children. Indeed, iTFA intake of >0.7 g/day was positively associated with being overweight, including obesity; differently, in the same study, no significant association for nTFAs was found [38]. The same results were confirmed in the cross-sectional study of Honicky and colleagues on children and adolescents who underwent a procedure to treat congenital heart disease.…”

Section: Obesitymentioning

confidence: 56%

The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns

Pipoyan

Stepanyan

et al. 2021

Foods

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Health effects of trans fatty acids (TFAs) on human organisms can vary according to their type, structure, composition, and origin. Even though the adverse health effects of industrial TFAs (iTFAs) have been widely discussed, the health effects of natural TFAs (nTFAs) are still questionable. Hence, it is important to review the literature and provide an overall picture on the health effects of different TFAs coming from industrial and ruminant sources, underlining those types that have adverse health effects as well as suggesting methods for reducing their harmful effects. Multiple databases (PubMed, Medline, Cochrane Library, etc.) were searched with the key words “trans fatty acid sources”, “ruminant”, “industrial”, “conjugated trans linoleic acid”, “human”, “coronary heart disease”, “cancer”, etc. Reference lists of the studies were scanned discussing the health effects of iTFAs and nTFAs. The review of the literature showed that iTFAs are found to be more harmful than ruminant-produced nTFAs. Although several beneficial effects (such as reduced risk of diabetes) for nTFAs have been observed, they should be used with caution. Since during labeling it is usually not mentioned whether the TFAs contained in food are of industrial or natural origin, the general suggestion is to reduce their consumption.

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Section: Obesitymentioning

confidence: 56%

The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns

Pipoyan

Stepanyan

et al. 2021

Foods

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“…In addition, a population-based study carried out with adolescents in Brazil investigated the association between breakfast patterns with weight status through principal component factor analysis, which observed that the “cereal, protein, fruit beverages and northern/northeastern” pattern was inversely associated with weight status [ 21 ]. Furthermore, foods representative of the breakfast pattern 3 “cold meats/sausages, cheeses and butter/cream” are predominantly of animal source, have a high energy density, are rich in saturated and trans fatty acids and added sugars, and are low in fiber, dietary factors considered to be risk factors for the development of obesity [ 23 , 69 , 70 ]. Although the breakfast patterns were not associated with cardiometabolic and nutritional markers in our study, breakfast skipping or breakfast patterns characterized by unhealthy foods may impact the long-term cardiovascular health of this population since they already have cardiovascular risk factors in childhood [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Consumption and Breakfast Patterns in Children and Adolescents with Congenital Heart Disease

Maraschim

Honicky

Moreno

et al. 2023

IJERPH

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Little is known about skipping breakfast and breakfast patterns (BP) and their evaluation according to sociodemographic, clinical, lifestyle, cardiometabolic and nutritional data in children and adolescents with congenital heart disease (CHD). This cross-sectional study with 232 children and adolescents with CHD identified the prevalence and patterns of the breakfast, described these according to sociodemographic, clinical and lifestyle characteristics, and assessed their association with cardiometabolic and nutritional markers. Breakfast patterns were identified by principal components, and bivariate and linear regression analysis were applied. Breakfast consumption was observed in 73% of participants. Four BP were identified: pattern 1 “milk, ultra-processed bread, and chocolate milk”, pattern 2 “margarine and processed bread”, pattern 3 “cold meats/sausages, cheeses and butter/cream” and pattern 4 “fruits/fruit juices, breakfast cereals, yogurts, and homemade cakes/pies and sweet snacks”. Family history for obesity and acyanotic CHD were associated with breakfast skipping. Younger participants and greater maternal education were associated with greater adherence to pattern 1 and pattern 4. Older participants and longer post-operative time showed greater adherence to pattern 3. No association between skipping breakfast or BP and cardiometabolic and nutritional markers was observed. Nonetheless, the findings reinforce the need for nutritional guidance for healthy breakfast, aiming to reduce the consumption of ultra-processed foods and to prioritize fresh and minimally processed foods.

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“…Basically, all pathologies often proposed to be associated with TFA intake, i.e., cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, are known to be related to obesity and thus to lipotoxicity, and the association between iTFA intake and obesity itself has been also reported [27]. This is why we thought it reasonable to test the representative iTFA, elaidate and rTFA, vaccenate in our established cellular model of lipotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Different Metabolism and Toxicity of TRANS Fatty Acids, Elaidate and Vaccenate Compared to Cis-Oleate in HepG2 Cells

Sarnyai

Kereszturi

Szirmai

et al. 2022

IJMS

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Trans fatty acids (TFAs) are not synthesized in the human body but are generally ingested in substantial amounts. The widespread view that TFAs, particularly those of industrial origin, are unhealthy and contribute to obesity, cardiovascular diseases and diabetes is based mostly on in vivo studies, and the underlying molecular mechanisms remain to be elucidated. Here, we used a hepatoma model of palmitate-induced lipotoxicity to compare the metabolism and effects of the representative industrial and ruminant TFAs, elaidate and vaccenate, respectively, with those of cis-oleate. Cellular FAs, triacylglycerols, diacylglycerols and ceramides were quantitated using chromatography, markers of stress and apoptosis were assessed at mRNA and protein levels, ultrastructural changes were examined by electron microscopy and viability was evaluated by MTT assay. While TFAs were just slightly more damaging than oleate when applied alone, they were remarkably less protective against palmitate toxicity in cotreatments. These differences correlated with their diverse incorporation into the accumulating diacylglycerols and ceramides. Our results provide in vitro evidence for the unfavorable metabolic features and potent stress-inducing character of TFAs in comparison with oleate. These findings strengthen the reasoning against dietary trans fat intake, and they can also help us better understand the molecular mechanisms of lipotoxicity.

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Association between trans fatty acid intake and overweight including obesity in 4 to 5‐year‐old children from the INMA study

Cited by 9 publications

References 36 publications

The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns

The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns

Consumption and Breakfast Patterns in Children and Adolescents with Congenital Heart Disease

Different Metabolism and Toxicity of TRANS Fatty Acids, Elaidate and Vaccenate Compared to Cis-Oleate in HepG2 Cells

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