Association between ideal cardiovascular health and the atherogenic index of plasma

Abstract

The American Heart Association aims to improve cardiovascular health by encouraging the general population to meet 7 cardiovascular health behaviors and factors. The atherogenic index of plasma (AIP) is an important index. Our aim is to evaluate the relationship between ideal cardiovascular health and the atherogenic index of plasma (AIP) in middle-aged Chinese men.A cross-sectional study was performed. A total of 27,824 middle-aged Chinese men were enrolled. The association between ideal cardiovascular health behaviors and factors and AIP was determined. The 7 cardiovascular health metrics were scored as follows: 0, poor; 1, general; and 2, ideal. The cardiovascular health status was classified according to the total score, as follows: 0 to 4, inadequate; 5 to 9, average; and 10 to 14, optimum. Analyses assessed the prevalence of 7 cardiovascular health metrics, its association with AIP. Logistic regression models were used to calculate odds ratios (ORs), adjusting for age.All 7 cardiovascular health metrics were shown to correlate with AIP (all P values < 0.05), and the strongest correlation existed between body mass and AIP, followed by total cholesterol and AIP. The mean AIP level increased with the decrease in the score of each of the 7 cardiovascular health metrics (all P values < 0.05). The subjects with poor cardiovascular health status had a 4.982-fold increase in the high risk of developing atherosclerosis, whereas a 1-point increase in the cardiovascular health score resulted a 0.046 reduction in AIP and a 22.3% reduction in the high-risk of developing atherosclerosis (OR = 0.777, 95% CI: 0.768–0.787).The ideal cardiovascular health score correlated significantly with AIP, and a 1-point increase in the cardiovascular health score led to a 0.046 reduction in AIP and a 22.3% reduction in the high risk of developing atherosclerosis. These validated the value of ideal cardiovascular health behaviors and factors in the prediction of high risk of developing cardiovascular diseases. Ideal cardiovascular health metrics are of great realistic significance for the prevention and control of atherosclerosis and cardiovascular diseases.

The Association of Ideal Cardiovascular Health and Atherogenic Index of Plasma in Rural Population: A Cross-Sectional Study from Northeast China

“…Several studies have accessed the relationship between CVH and AS markers [13,23,31]. Kulshreshtha A. et al confirmed that ideal CVH had a strong inverse correlation with carotid IMT, another preclinical marker for AS [13].…”

“…AIP was another significant predictor of AS [18,19] and was more convenient and economical compared B-mode ultrasound or CT. Shen et al indicated that the ideal CVH score correlated significantly with AIP, and a 1-point increase in the CVH score could lead to a 0.046 reduction in AIP and a 22.3% reduction in the high risk of developing AS [23]. The study subjects in the study conducted by Shen et al were middle-aged men in southeastern China.…”

“…BMI exhibited the greatest effect on AIP (PR: 3.76, 95% CI: 3.27–4.32), followed by the FPG level, TC level, BP level, diet score, smoking status, and physical activity, after adjustment for covariates. Epidemiological studies have shown associations of BMI, FPG, TC, diet, BP, physical activity, and smoking with AIP (either increased TG or decreased HDL) [22,23,29,33,34]. An inverse gradient relationship existed between the number of ideal CVH metrics and the prevalence of high AIP.…”

“…According to previous studies, AIP was calculated as log (TG/HDL) and was classified into three groups: low- (<0.11), intermediate- (0.11–0.21) and high-risk (>0.21) [18,23,28,29]. In accordance with definition by previous studies [9,30], ideal health is all seven health metrics at ideal levels, intermediate health is at least one health metric at intermediate level, but no poor health metrics, and poor health is at least one of seven health metrics at poor level.…”

“…Shen et al indicated that the ideal CVH score correlated significantly with AIP, and a 1-point increase in the CVH score could lead to a 0.046 reduction in AIP and a 22.3% reduction in the high risk of developing AS (accessed by AIP > 0.21) in middle-aged men from southeastern China [23]. However, uncertainty remains regarding the relationship between the ideal CVH metrics and AIP because of the limited number of previous studies and lack of study in the general population.…”