Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Abstract

BackgroundA number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis.MethodsA literature search was conducted among six English databases (PubMed, Embase, Web of Science, Science Direct, SpringerLink and EBSCO) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases) to identify studies involving association between IL-10 −1082G/A, −819T/C, and −592A/C polymorphisms and TB susceptibility before May. 2013. Statistical analysis was performed using Revman 5.0 and Stata 12.0.ResultsA total of 31 studies with 6,559 cases and 7,768 controls were included in this meta-analysis. The results showed that three polymorphisms (-1082G/A, -819T/C, and -592A/C) in the IL-10 gene were not associated with the risk of TB in general population. In the subgroup analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with TB risk in Europeans (AA+AG vs. GG: OR = 0.57, 95% CI = 0. 0.37–0.89, P = 0.01) and Americans (AA+AG vs. GG: OR = 0.39, 95% CI = 0.27–0.57, P<0.01), and IL-10 -819T/C (C allele vs. T allele: OR = 0.83, 95% CI = 0.72–0.96, P = 0.01) and -592A/C (CC+AC vs. AA: OR = 0.65, 95% CI = 0.49–0.85, P = 0.002) polymorphisms were significantly associated with TB risk in Asians.ConclusionThis meta-analysis provides strong evidence that IL-10-1082G/A polymorphism was associated with TB risk in Europeans and Americans, and IL-10 -819T/C and -592A/C polymorphisms could be risk factors for TB in Asians. Additional well designed large studies were required for the validation of our results.

Metronidazole—but not IL-10 or prednisolone—rescues Trichuris muris infected C57BL/6 IL-10 deficient mice from severe disease

“…in several domestic animals and humans. Given that IL-10 polymorphisms have been discovered and associated with other disease manifestations in dogs (Short et al, 2009), cattle (Verschoor et al, 2009) and humans (Liang et al, 2014;Zou et al, 2014), it is reasonable to explore this mouse model to understand the pathogenesis of Trichuris spp. in their natural hosts.…”

The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection

“…Several genetic polymorphisms have been associated with susceptibility to Mtb infection in monocytes/macrophages, including the promoter regions of IL10 (Liang, Guo, Li, & Kong, 2014; Moraes et al, 2004), TNFRI, and TNFRII (Stein et al, 2007). Polymorphisms in the Vitamin D (Vit D) Receptor (VDR) gene are also associated with susceptibility to Mtb (Wilkinson et al, 2000).…”

Genomics and infectious disease: a call to identify the ethical, legal and social implications for public health and clinical practice

“…Gene variation has been associated with susceptibility to active tuberculosis in specific populations. For example, a particular gene variant in the promoter region of the IL10 gene is associated with a 40 to 60% increased risk of developing active tuberculosis among Europeans and Americans [75]. Further research on host genomics is likely to identify genetic contributions to the phenotypic variability seen in tuberculosis infection, and lead to improvements in the efficacy of preventive and therapeutic interventions.…”