Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Wt, Yin; Yp, Pan; Li, Lin

doi:10.4238/gmr.15017325

Cited by 21 publications

(27 citation statements)

References 37 publications

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“…On the other hand, ED may result from the expression of cytokines and proinflammatory markers (among them, IL‐1, IL‐6, and TNF‐α), and other factors that are assigned to interact with platelets and leukocytes, along with inflammatory and prothrombotic factors 27 . A significant positive correlation between IL‐1β and periodontitis was reported in a recent meta‐analysis 34 …”

Section: Discussionmentioning

confidence: 99%

“…However, in the present study, despite the fact that IL‐1β values are higher in individuals with CP, there are no significant differences between individuals with and without CP and no correlation between the extent and severity of periodontitis. Other studies also failed to confirm this association 34 , 35 . For this reason, relevance of IL‐1β in the pathogenesis of periodontitis remains controversial 36 …”

Section: Discussionmentioning

confidence: 99%

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Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

Moura

Navarro

Silva

et al. 2017

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

Moura

Navarro

Silva

et al. 2017

Journal of Periodontology

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“…Gene variants have been shown to alter the expression or function of the proteins responsible for immune response, 4 and there is growing evidence to support the importance of genetic variability (gene polymorphisms) for predicting the risk of GVHD in individual recipients. In the present study, the LASSO procedure selected polymorphisms in known cytokine genes such as IL1B, 35,36 …”

Section: Discussionmentioning

confidence: 99%

A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms

et al. 2018

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Key Points• A risk model using donor and recipient cytokine gene polymorphisms and clinical variables significantly improves GVHD risk stratification.• The model is useful in identifying patients with low-risk of developing severe GVHD, but results must be confirmed in prospective studies.Despite considerable advances in our understanding of the pathophysiology of graft-versus-host disease (GVHD), its prediction remains unresolved and depends mainly on clinical data. The aim of this study is to build a predictive model based on clinical variables and cytokine gene polymorphism for predicting acute GVHD (aGVHD) and chronic GVHD (cGVHD) from the analysis of a large cohort of HLA-identical sibling donor allogeneic stem cell transplant (allo-SCT) patients.A total of 25 SNPs in 12 cytokine genes were evaluated in 509 patients. Data were analyzed using a linear regression model and the least absolute shrinkage and selection operator (LASSO).The statistical model was constructed by randomly selecting 85% of cases (training set), and the predictive ability was confirmed based on the remaining 15% of cases (test set). Models including clinical and genetic variables (CG-M) predicted severe aGVHD significantly better than models including only clinical variables (C-M) or only genetic variables (G-M). For grades 3-4 aGVHD, the correct classification rates (CCR1) were: 100% for CG-M, 88% for G-M, and 50% for C-M. On the other hand, CG-M and G-M predicted extensive cGVHD better than C-M (CCR1: 80% vs. 66.7%, respectively). A risk score was calculated based on LASSO multivariate analyses. It was able to correctly stratify patients who developed grades 3-4 aGVHD (P , .001) and extensive cGVHD (P , .001). The novel predictive models proposed here improve the prediction of severe GVHD after allo-SCT. This approach could facilitate personalized risk-adapted clinical management of patients undergoing allo-SCT.

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“…However, considerable variations were seen for the carriage rates of the IL1 composite genotype across populations, and among studies, there were contradictory results. To clarify the role of these polymorphisms in the etiology of periodontitis, several systematic reviews and meta‐analyses have been performed . Generally, these concluded that the single polymorphism or the composite genotype are significantly associated to CP.…”

Section: Introductionmentioning

confidence: 99%

Quality of methods and reporting in association studies of chronic periodontitis and IL1A−889 and IL1B+3953/4 SNPs: A systematic review

Citterio

Romano

Ferrarotti

et al. 2019

J of Periodontal Research

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Objective The aim of this systematic review was to evaluate the quality of reporting and methodology in genetic association studies between IL1A −889 and IL1B +3954 polymorphisms and chronic periodontitis. Background Evidence provided by periodontal research on genetic risk factors is of uttermost importance in clinical practice as a possible diagnostic and prognostic tool for periodontitis. Inadequate reporting of results as well as high risk of bias due to methodological inconsistency hampers the integration of evidence in terms of clinical applicability. Methods This review includes case‐control studies in humans published between 1997 and July 2017. Searching was conducted through MEDLINE, EMBASE, and search handing. Specific scoring systems have been developed to evaluate the quality of methods and reporting. Each article was scored according to its adequacy, and then, the total number and the percentage of items positively qualified for both methods and reporting were calculated. The quality of methods in studies scoring 0‐6, 7‐12, and 13‐16 was, respectively, considered poor, moderate, and good. For reporting, scores of 0‐9, 10‐18, and 19‐26 were deemed of poor, moderate, and good quality, respectively. Pearson's correlation coefficient was calculated to explore the correlation between the year of publication and the quality in terms of methods and reporting. Results From the 531 screened studies, 52 met the inclusion criteria and were thus included in the study. The quality of methods and reporting of published genetic association papers on IL1 and chronic periodontitis is moderate. On a scale from 0 to 16, the mean score for methods of the reviewed studies was 8.19 ± 1.93. The items more frequently considered inadequate concerned the handling of confounders in statistical analysis, especially oral hygiene habits, socioeconomic status, subgingival colonization of specific periodontal pathogens, and stress. A significant positive correlation was found between the year of publication and the quality scores in terms of method (r = 0.401, P = 0.003). In terms of reporting, the mean score was 14.83 ± 3.04 on a scale from 0 to 26 and it was considered overall moderate. No statistically significant correlation was found between the year of publication and the quality of reporting (P = 0.266). Conclusions The association between IL1A −889 and IL1B +3954 polymorphisms and chronic periodontitis is questionable due to methodological inconsistency. Evidence arising from meta‐analysis is unreliable due to high risk of bias and moderate quality in terms of reporting.

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Association between IL-1α rs17561 and IL-1β rs1143634 polymorphisms and periodontitis: a meta-analysis

Cited by 21 publications

References 37 publications

Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms

Quality of methods and reporting in association studies of chronic periodontitis and IL1A−889 and IL1B+3953/4 SNPs: A systematic review

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