Association Between IL12A rs568408, IL12B rs3212227 and IL-12 Receptor rs383483 Polymorphisms and Risk of Pulmonary Tuberculosis

Taheri, Mohsen; Naderi, Mohammad; Hashemi, Mohammad; Abiri, Marzieh; Sarabandi, Maryam

doi:10.5812/archcid.39318

Cited by 3 publications

(5 citation statements)

References 23 publications

(25 reference statements)

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“…We investigated the impact of IL12A rs568408 gene polymorphisms on risk pulmonary tuberculosis in a sample was living in southeast (13) . The IL12A rs568408 variant was not a risk factor for susceptibility to pulmonary tuberculosis in codominant, dominant and recessive tested inheritance models (11) , but another study showed association between IL12A rs568408 polymorphisms and risk of pulmonary tuberculosis in Chinese population and It was found that genetic variants AG/GG of rs2243115 (IL12A) were associated with a decreased risk of pulmonary tuberculosis (12) .…”

Section: Discussionmentioning

confidence: 98%

“…Polymorphism of IL12A gene (G/A rs568408 genotype) was examined by using Tetra-ARMS-PCR technology. The PCR reaction was carried out on a DNA template with a pair of specific primers (Alpha DNA, Canada) that designed according to (11) . Table (1), 20 μl was the total volume of reaction mix (PioNeer, Korea), and the molecular marker size (Promega, USA) 100-2000 base pair.…”

Section: Genotyping Of Il12a Gene (G/a Rs568408 Genotype)mentioning

confidence: 99%

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Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population

2020

IJFMT

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The study included eighty samples. This cases-controlled study was performed including fifty Pulmonary tuberculosis patients, their ages ranged from 12 to 77 year (27 female and 23 male) and thirty controls (healthy), their ages ranged from 19 to 58 year (15 female and 15 male). We confined the frequency of IL12A gene (G/A rs568408 genotype) polymorphism by Tetra-ARMS PCR (Tetra amplification refractory mutation system-polymerase chain reaction) technology. Also, we determined the association of IL12A Gene (G/A rs568408 genotype) polymorphism with Pulmonary tuberculosis patients in Baghdad. Statistical results showed significant difference in genotype frequency of IL12A Gene (G/A rs568408 genotype) polymorphism between Pulmonary tuberculosis patients and control (healthy). The G allele shows high frequency in Pulmonary tuberculosis patients comparison with control (healthy) and present related with etiological fraction risk of Pulmonary tuberculosis patients and its ratio 62% in patients and 51.67% in control (healthy), While A allele shows high frequency in control (healthy) comparison with Pulmonary tuberculosis patients and present related with protective fraction of Pulmonary tuberculosis patients and its ratio 48.33% in control and 38% in Pulmonary tuberculosis patients. The genotypes of GG and AA homozygotes shows high frequency in Pulmonary tuberculosis patients comparison with control (healthy), and its ratio 42% and 18% respectively in Pulmonary tuberculosis patients, while its ratio 3.33% and 0% respectively in control (healthy), also GG and AA genotypes appear related with etiological fraction risk of Pulmonary tuberculosis patients, while the GA heterozygote show high frequency in control (healthy) and its ratio 96%, GA genotypes related with preventive fraction of Pulmonary tuberculosis patients. Our findings demonstrate that the IL12A Gene (G/A rs568408 genotype) polymorphism may represent a significant risk factor for pulmonary tuberculosis patients in Baghdad population.

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Section: Discussionmentioning

confidence: 98%

Section: Genotyping Of Il12a Gene (G/a Rs568408 Genotype)mentioning

confidence: 99%

Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population

2020

IJFMT

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“…A crucial cytokine in the fight against intracellular infections, interleukin-12, encourages the growth of Th1 cells, cell-mediated cytotoxicity, and IFN-gamma production [ 16 ]. Various studies have shown that the two genes that code for IL-12, IL12A, and IL12B, have numerous functional polymorphism sites that may have an impact on the development and spread of lung cancer [ 17 ] and tuberculosis [ 18 ]. Tan et al .…”

Section: Discussionmentioning

confidence: 99%

“…In a sample of the southeast Iranian population, research revealed that IL12A rs568408, polymorphism was not a significant genetic determinant for resistance or susceptibility to pulmonary tuberculosis. In patients and controls, the rates of the GA and AA genotypes of the IL12A rs568408 variation were 38.5%, 1.7%, and 37.3%, 1.1%, respectively [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients

AL-Khikani

Alkhafaji²

2022

Tzu Chi Medical Journal

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A BSTRACT Objectives: The objective of the current study was to check the link between potential polymorphism in IL12A rs568408 and the possible risk of COVID-19 in the Iraqi population. Materials and Methods: Allele specific-polymerase chain reaction (PCR) technique was carried out for genotyping and detection of IL12A rs568408 gene polymorphism in a case–control study of 125 severe COVID-19 cases and 60 controls. Patients were admitted to either Marjan medical city or Al-Sadeq hospital’s COVID-19 wards between January and June 2022 in Iraq. The diagnosis of COVID-19 in each patient was confirmed by severe acute respiratory coronavirus 2-positive reverse transcription-PCR. Results: The distribution of both genotyping and allele frequencies of IL-12A rs568408 revealed significant differences between patients and control groups ( P = 0.006 and P = 0.001, respectively). The IL12A rs568408 AA and AG variant genotypes were associated with a significantly increased risk of COVID-19 (odds ratio [OR] = 5.19, 95% confidence interval [CI]: 1.13–23.82; P = 0.034) and (OR = 2.39, 95% CI = 1.16–4.94, P = 0.018), respectively, compared with the wild-type GG homozygote. Conclusion: These findings indicate that IL12A rs568408 GA/AA variant may contribute to the risk of COVID-19. This study is the first report about the association of IL12A rs568408 with COVID-19.

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“…9 IL-12 has been shown to inhibit the proliferation and metastasis of various malignant tumors, in vitro and in vivo, 10 and to inhibit the differentiation of natural killer and Th2 T helper cells, contributing to a strong anti-tumor effect. 11 IL-12 is encoded by two genes, IL12A and IL12B, and numerous studies have demonstrated that the IL12A and IL12B genes include multiple functional polymorphic sites that might affect the occurrence and progression of non-Hodgkin lymphoma, 12 tuberculosis, 13 autoimmune disease, 14 gastric carcinoma, 15 lung carcinoma, 16 and other malignancies. 17 Tan et al showed that the IL12A rs568408 variant may be a marker single-nucleotide polymorphism (SNP) associated with an increased risk of poor HBV clearance and HBV-related HCC development.…”

Section: Introductionmentioning

confidence: 99%

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

et al. 2020

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Background Interleukin-12 (IL-12) is considered to be a risk factor for cancer; however, its role in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore the impacts of the IL-12 rs3212227 and rs568408 gene polymorphisms on HCC. Methods We searched PubMed, Embase, Web of Science, and Chinese Knowledge Infrastructure databases for studies on the associations between HCC and IL-12 rs568408 and rs3212227 polymorphisms published prior to 1 May 2020. The effects of the polymorphisms on HCC susceptibility were presented as odds ratios (ORs) and associated 95% confidence intervals. Results Seven studies were ultimately included, including 2375 cases and 3445 controls. The rs3212227 polymorphism was significantly associated with the risk of HCC in both the dominant model (CC+AC vs. AA, OR=1.22) and the allele model (C vs. A, OR=1.12). Combined analysis of rs568408 yielded a significant relative risk for HCC in the dominant (AA+AG vs. GG, OR=1.13), recessive (AA vs. AG+GG, OR=1.72), allele (A vs. G, OR=1.29), heterozygote (AG vs. GG, OR=1.27), and homozygote models (AA vs. GG, OR 1.17). Conclusion The IL-12 rs3212227 and rs568408 gene polymorphisms are associated with an increased risk of HCC.

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Association Between IL12A rs568408, IL12B rs3212227 and IL-12 Receptor rs383483 Polymorphisms and Risk of Pulmonary Tuberculosis

Abstract: Background: Interleukine-12 (IL-12) induced interferon-γ (IFN-γ) production and development of T cells into Th1 cells, which has a

Cited by 3 publications

References 23 publications

Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population

Association between IL12A Gene of G/A genotype Polymorphism and Pulmonary Tuberculosis Risk in Baghdad Population

The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis

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