Association between IL12B polymorphisms and tuberculosis risk: A meta-analysis

Liu, Guoyuan; Li, Guanghua; Xu, Ying; Song, Na; Shen, Suqin; Jiang, Deke; Zeng, Wenjiao; Wang, Honghai

doi:10.1016/j.meegid.2013.12.008

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…By contrast, a third work revealed that the IL‐12B (p40) +1188 A/C polymorphism may have no impact on the development of TB (Arji et al., ). These results are in agreement with some studies and in contradiction to those conducted in other populations, such as African American, Indian, South African and European populations (Liu et al., ; Ma et al., ; Möller, Nebel, van Helden, Schreiber, & Hoal, ; Morris et al., ; Selvaraj et al., ). The involvement of the Il12/IFN‐γ axis in the susceptibility to TB in the Moroccan population is also supported by a recent finding, which revealed that six SNPs (rs1400654, rs3024861, rs6752770, rs1031509, rs7572482 and rs897200) were found to be more common in TB patients than they were in healthy controls ( p < .05; Sabri et al., ).…”

Section: Candidate Genes and The Risk Of Developing Tbsupporting

confidence: 90%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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Section: Candidate Genes and The Risk Of Developing Tbsupporting

confidence: 90%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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“…The concentrations of these chemokines and cytokines are determined by allelic frequency and have been involved in response to M. tuberculosis infection. Likewise, genes coding for proteins such as CCL2 [77], IL-17F, IL-17A [78], and IL-12 [37,79] have been described as polymorphic; variation in allele frequency is affected by ethnic variation, affecting the antimycobacterial response, and thus may be driving the higher risk for development of TB among different populations. The examples emphasize the importance to adjust by ethnicity of the population at the time of reporting the results as these clearly impact biomarker concentrations.…”

Section: Discussionmentioning

confidence: 99%

Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review

Herrera

Vera

Keynan

et al. 2020

Journal of Immunology Research

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Background. Immune parameters (IP) have been extensively studied to distinguish between latent tuberculosis (LTBI) and active tuberculosis (TB). Objective. To determine the IP associated with LTBI, compared to active TB and individuals not infected by M. tuberculosis published in literature. Methods. We conducted a systematic search using Google Scholar and PubMed databases, combining the MeSH terms latent tuberculosis, Mycobacterium tuberculosis, cytokines, and biological markers, with the free terms, biomarkers and cytokines. Spanish, English, and Portuguese articles comparing the concentration of IP associated with LTBI, either in plasma/serum or in vitro, in adults and nonimmunocompromised versus individuals with TB or without M. tuberculosis infection between 2006 July and 2018 July were included. Two blinded reviewers carried out the searches, read the abstracts, and selected the articles for analysis. Participants’ information, diagnostic criteria, IP, detection methods, and biases were collected. Results. We analyzed 36 articles (of 637 abstracts) with 93 different biomarkers in different samples. We found 24 parameters that were increased only in active TB (TGF-α, CSF3, CSF2, CCL1 [I-309], IL-7, TGF-β1, CCL3 [MIP-1α], sIL-2R, TNF-β, CCL7 [MCP-3], IFN-α, fractalkine, I-TAG, CCL8 [MCP-2], CCL21 [6Ckine], PDGF, IL-22, VEGF-A, LXA4, PGE2, PGF2α, sCD163, sCD14, and 15-Epi-LXA4), five were elevated in LTBI (IL-5, IL-17F, IL-1, CCL20 [MIP-3α], and ICAM-1), and two substances were increased among uninfected individuals (IL-23 and basic FGF). We found high heterogeneity between studies including failure to account for the time/illness of the individuals studied; varied samples and protocols; different clinical classification of TB; different laboratory methods for IP detection, which in turn leads to variable units of measurement and assay sensitivities; and selection bias regarding TST and booster effect. None of the studies adjusted the analysis for the effect of ethnicity. Conclusions. It is mandatory to harmonize the study of immune parameters for LTBI diagnosis. This systematic review is registered with PROSPERO CRD42017073289.

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“…Zhang et al showed that a functional SNP in the promoter gene encoding Interleukin 6 (IL6) is associated with susceptibility to tuberculosis [ 23 ]. Furthermore, among others, SNPs in Interleukin 1β ( IL1B ), IL12 , IFNG , Interleukin 10 ( IL10 ) and Tumor Necrosis Factor α ( TNFα ) genes were described in relation with risk to tuberculosis disease [ 24 , 25 , 26 ]. Recently we have demonstrated that the Interleukin 17A ( IL17A ) rs2275913 SNP is associated with protection to tuberculosis but related to higher disease severity in Argentina [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

The IFNG rs1861494 Single Nucleotide Polymorphism Is Associated with Protection against Tuberculosis Disease in Argentina

Rolandelli

Pellegrini

Amiano

et al. 2018

Genes

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Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population.

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Association between IL12B polymorphisms and tuberculosis risk: A meta-analysis

Cited by 11 publications

References 31 publications

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review

The IFNG rs1861494 Single Nucleotide Polymorphism Is Associated with Protection against Tuberculosis Disease in Argentina

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